Expression of KCNQ2 in melanoma - The Human Protein Atlas

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KCNQ2

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TISSUE

CELL TYPE

PATHOLOGY

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MELANOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

KCNQ2 is not prognostic in melanoma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 0.01
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

0.0

Number of samples

102

Samples

Sample	Description	FPKM
TCGA-EB-A4IQ-01A	42 years, female, asian, stage:iiib, dead, 636 days	1.8
TCGA-BF-A5ER-01A	63 years, male, white, stage:iic, alive, 327 days	0.9
TCGA-ER-A19T-01A	51 years, male, white, stage:iv, dead, 270 days	0.7
TCGA-BF-AAP8-01A	58 years, male, white, stage:iic, alive, 447 days	0.2
TCGA-EB-A5UM-01A	48 years, female, white, stage:iic, alive, 779 days	0.2
TCGA-D3-A5GT-01A	43 years, male, white, stage:iiic, alive, 487 days	0.2
TCGA-BF-AAOU-01A	73 years, female, white, stage:iic, alive, 476 days	0.1
TCGA-BF-A5EP-01A	75 years, female, white, stage:iiic, alive, 335 days	0.1
TCGA-IH-A3EA-01A	61 years, male, white, stage:iic, alive, 524 days	0.1
TCGA-GF-A2C7-01A	48 years, male, white, stage:iic, alive, 21 days	0.1
TCGA-BF-A1PU-01A	46 years, female, white, stage:iic, alive, 387 days	0.1
TCGA-EB-A3HV-01A	37 years, male, white, stage:iic, alive, 39 days	0.0
TCGA-ER-A42H-01A	77 years, male, white, dead, 426 days	0.0
TCGA-FR-A728-01A	54 years, female, white, stage:iiib, alive, 583 days	0.0
TCGA-FR-A2OS-01A	49 years, female, white, stage:iic, dead, 368 days	0.0
TCGA-BF-A1PV-01A	74 years, female, white, stage:iic, alive, 14 days	0.0
TCGA-BF-A5ES-01A	76 years, female, white, stage:iic, alive, 490 days	0.0
TCGA-ER-A196-01A	64 years, female, white, stage:iic, alive, 1785 days	0.0
TCGA-EB-A550-01A	75 years, female, white, stage:iic, dead, 264 days	0.0
TCGA-BF-AAP2-01A	62 years, male, white, stage:iib, alive, 405 days	0.0
TCGA-EB-A4OZ-01A	42 years, female, white, stage:iiic, alive, 620 days	0.0
TCGA-EB-A4XL-01A	56 years, female, white, stage:iic, alive, 777 days	0.0
TCGA-XV-AAZV-01A	56 years, female, white, stage:ii, alive, 412 days	0.0
TCGA-BF-A5EQ-01A	63 years, male, white, stage:iic, alive, 323 days	0.0
TCGA-HR-A5NC-01A	90 years, female, alive, 1000 days	0.0
TCGA-EB-A41B-01A	76 years, female, white, stage:iic, alive, 291 days	0.0
TCGA-EB-A551-01A	78 years, female, white, stage:iiic, alive, 590 days	0.0
TCGA-BF-A3DL-01A	84 years, female, white, stage:iiib, alive, 769 days	0.0
TCGA-EB-A51B-01A	53 years, male, white, stage:iic, alive, 931 days	0.0
TCGA-EB-A3XE-01A	77 years, female, white, stage:iia, alive, 180 days	0.0
TCGA-D9-A3Z4-01A	54 years, male, white, stage:iiic, dead, 519 days	0.0
TCGA-GF-A769-01A	39 years, male, white, stage:iic, dead, 1070 days	0.0
TCGA-WE-A8K4-01A	85 years, male, white, stage:iib, alive, 614 days	0.0
TCGA-GN-A8LN-01A	68 years, male, white, stage:iic, alive, 772 days	0.0
TCGA-YG-AA3N-01A	67 years, male, stage:iic, alive, 306 days	0.0
TCGA-BF-A3DM-01A	63 years, male, white, stage:iia, alive, 601 days	0.0
TCGA-ER-A2NB-01A	57 years, male, white, stage:iiib, dead, 857 days	0.0
TCGA-EB-A5SF-01A	78 years, female, white, stage:iic, dead, 369 days	0.0
TCGA-EB-A3Y7-01A	86 years, female, white, stage:iiib, dead, 326 days	0.0
TCGA-ER-A2NF-01A	53 years, male, white, stage:iiib, dead, 877 days	0.0
TCGA-EB-A1NK-01A	48 years, male, white, stage:iic, alive, 1039 days	0.0
TCGA-FW-A5DX-01A	71 years, male, white, stage:iiic, alive, 640 days	0.0
TCGA-EB-A3Y6-01A	56 years, female, white, stage:iic, alive, 126 days	0.0
TCGA-EB-A44N-01A	59 years, male, white, stage:iic, dead, 205 days	0.0
TCGA-EB-A3XD-01A	53 years, female, white, stage:iic, alive, 1160 days	0.0
TCGA-BF-AAP1-01A	86 years, male, white, stage:iic, alive, 409 days	0.0
TCGA-XV-AAZY-01A	76 years, female, white, stage:iiic, alive, 405 days	0.0
TCGA-BF-AAOX-01A	83 years, male, white, stage:iic, alive, 444 days	0.0
TCGA-EB-A6QY-01A	71 years, male, white, stage:iic, alive, 382 days	0.0
TCGA-EB-A5FP-01A	65 years, female, white, stage:iv, dead, 454 days	0.0
TCGA-BF-AAP6-01A	55 years, male, white, stage:iii, alive, 325 days	0.0
TCGA-EB-A5VU-01A	56 years, male, asian, stage:iiib, dead, 321 days	0.0
TCGA-DA-A960-01A	73 years, male, white, stage:iib, alive, 804 days	0.0
TCGA-EB-A24D-01A	72 years, male, white, stage:iiib, alive, 645 days	0.0
TCGA-EB-A42Y-01A	73 years, female, asian, stage:iic, dead, 721 days	0.0
TCGA-BF-A1PX-01A	56 years, male, white, stage:iiib, dead, 282 days	0.0
TCGA-BF-A9VF-01A	77 years, male, white, stage:iic, alive, 440 days	0.0
TCGA-XV-A9W5-01A	51 years, male, white, stage:i/ii nos, alive, 392 days	0.0
TCGA-EB-A553-01A	62 years, male, white, stage:iic, alive, 226 days	0.0
TCGA-EB-A85I-01A	66 years, male, white, stage:iic, alive, 362 days	0.0
TCGA-EB-A85J-01A	66 years, female, white, stage:iib, alive, 360 days	0.0
TCGA-GN-A263-01A	24 years, male, white, stage:iv, dead, 467 days	0.0
TCGA-EB-A97M-01A	66 years, male, white, stage:iic, alive, 414 days	0.0
TCGA-EB-A6QZ-01A	76 years, female, white, stage:iia, dead, 352 days	0.0
TCGA-EB-A3XF-01A	57 years, male, white, stage:iic, alive, 278 days	0.0
TCGA-BF-A5EO-01A	65 years, male, white, stage:iic, alive, 703 days	0.0
TCGA-EB-A299-01A	63 years, male, white, stage:iia, alive, 378 days	0.0
TCGA-XV-AAZW-01A	62 years, female, white, stage:ii, dead, 393 days	0.0
TCGA-BF-AAP4-01A	61 years, male, white, stage:iic, alive, 335 days	0.0
TCGA-EB-A44P-01A	58 years, female, white, stage:iic, alive, 741 days	0.0
TCGA-GN-A4U5-01A	61 years, female, white, stage:ib, alive, 1156 days	0.0
TCGA-EB-A5SE-01A	73 years, male, white, stage:iib, dead, 401 days	0.0
TCGA-EB-A4IS-01A	77 years, male, white, stage:iib, alive, 774 days	0.0
TCGA-FR-A3R1-01A	69 years, male, white, stage:iic, alive, 685 days	0.0
TCGA-EB-A3XB-01A	63 years, male, white, stage:ii, alive, 796 days	0.0
TCGA-BF-A1Q0-01A	80 years, male, white, stage:iic, alive, 831 days	0.0
TCGA-EB-A42Z-01A	49 years, male, asian, stage:iiic, alive, 441 days	0.0
TCGA-FR-A726-01A	90 years, male, white, stage:iic, dead, 305 days	0.0
TCGA-ER-A19K-01A	79 years, female, white, stage:iic, dead, 469 days	0.0
TCGA-BF-A1PZ-01A	71 years, female, white, stage:iib, alive, 853 days	0.0
TCGA-GN-A26C-01A	77 years, male, white, stage:iiic, dead, 821 days	0.0
TCGA-EB-A4OY-01A	65 years, female, white, stage:iiib, alive, 977 days	0.0
TCGA-EB-A82C-01A	70 years, female, asian, stage:iic, alive, 17 days	0.0
TCGA-ER-A194-01A	77 years, male, white, dead, 1354 days	0.0
TCGA-D9-A4Z3-01A	73 years, female, white, stage:iiic, alive, 505 days	0.0
TCGA-FS-A1ZN-01A	43 years, male, white, stage:iiia, dead, 730 days	0.0
TCGA-EB-A57M-01A	56 years, male, asian, stage:iiib, dead, 472 days	0.0
TCGA-BF-AAP7-01A	76 years, female, white, stage:iic, alive, 318 days	0.0
TCGA-EB-A4P0-01A	82 years, male, white, stage:iic, dead, 326 days	0.0
TCGA-EB-A82B-01A	58 years, female, asian, stage:iii, alive, 390 days	0.0
TCGA-XV-A9W2-01A	81 years, male, white, stage:i, alive, 417 days	0.0
TCGA-EB-A41A-01A	90 years, male, white, stage:iic, alive, 262 days	0.0
TCGA-BF-A3DJ-01A	36 years, female, white, stage:iiib, alive, 464 days	0.0
TCGA-D9-A4Z5-01A	68 years, male, white, stage:iib, alive, 218 days	0.0
TCGA-BF-A3DN-01A	81 years, female, white, stage:iiic, alive, 717 days	0.0
TCGA-D9-A4Z2-01A	50 years, male, white, stage:iiic, dead, 190 days	0.0
TCGA-EB-A431-01A	34 years, male, white, stage:iic, alive, 568 days	0.0
TCGA-EB-A6R0-01A	58 years, female, white, stage:iic, dead, 608 days	0.0
TCGA-EB-A24C-01A	56 years, male, white, alive, 632 days	0.0
TCGA-EB-A44O-01A	69 years, male, white, stage:iib, alive, 81 days	0.0
TCGA-EB-A3XC-01A	74 years, male, white, stage:iic, alive, 650 days	0.0
TCGA-XV-A9VZ-01A	90 years, female, white, stage:ii, alive, 11 days	0.0
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MELANOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA016642	Antibody HPA057112
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.