Expression of HSP90AB1 in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 437.85
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

578.3

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	1567.1
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	1548.0
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	1467.0
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	1162.6
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	1096.7
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	1036.0
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	1010.7
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	952.0
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	951.0
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	920.9
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	915.5
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	845.1
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	843.8
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	836.9
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	831.6
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	829.7
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	827.5
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	816.8
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	813.6
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	809.5
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	791.0
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	769.2
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	735.8
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	731.1
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	729.1
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	725.7
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	722.9
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	721.0
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	712.1
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	711.4
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	709.4
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	699.9
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	698.2
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	694.9
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	694.7
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	686.8
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	685.5
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	680.9
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	676.0
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	667.2
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	666.9
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	665.4
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	665.2
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	664.3
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	662.1
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	661.3
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	655.3
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	648.2
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	648.1
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	643.3
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	641.5
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	636.8
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	622.7
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	621.0
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	619.8
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	618.1
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	614.5
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	613.0
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	609.6
TCGA-CL-4957-01A	79 years, female, dead, 425 days	607.4
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	600.2
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	596.0
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	590.0
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	588.8
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	586.8
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	586.4
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	584.4
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	583.4
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	579.2
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	576.3
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	574.3
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	565.9
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	564.2
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	563.1
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	560.7
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	557.1
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	556.1
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	555.7
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	554.3
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	553.3
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	552.7
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	552.6
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	546.1
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	544.7
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	542.5
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	541.6
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	532.5
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	531.8
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	530.9
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	527.5
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	527.1
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	526.9
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	523.8
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	522.1
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	520.6
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	518.2
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	517.7
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	512.5
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	503.1
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	499.7
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	497.5
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	494.7
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	490.5
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	487.9
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	484.6
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	483.3
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	482.8
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	478.9
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	476.4
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	473.6
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	472.2
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	459.0
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	457.7
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	450.8
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	450.3
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	444.8
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	442.9
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	439.5
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	438.1
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	437.6
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	436.6
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	434.3
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	432.1
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	430.4
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	428.9
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	423.8
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	423.1
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	420.5
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	420.3
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	417.7
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	412.4
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	411.2
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	410.5
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	406.3
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	383.1
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	378.0
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	376.5
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	373.9
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	372.9
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	350.5
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	342.5
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	332.7
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	332.5
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	327.2
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	315.9
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	311.7
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	303.1
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	299.6
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	295.8
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	285.2
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	272.4
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	265.4
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	254.9
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	245.8
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	236.5
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	232.9
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	230.9
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	226.4
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	200.8
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