Expression of CHCHD2 in glioma - The Human Protein Atlas

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CHCHD2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CHCHD2 is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 543.98
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

687.5

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	8130.0
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	6462.0
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	6015.1
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	5436.9
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	4559.8
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	4539.1
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	4036.0
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	3283.2
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	2388.2
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	2097.9
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	1751.3
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	1512.8
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	1379.0
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	969.1
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	934.5
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	933.4
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	921.3
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	844.5
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	810.0
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	796.2
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	756.3
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	672.2
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	671.6
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	666.5
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	664.6
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	636.5
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	596.9
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	586.2
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	566.8
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	564.0
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	556.7
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	553.0
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	535.0
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	531.0
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	514.8
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	511.7
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	498.0
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	491.4
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	490.9
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	472.4
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	470.1
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	466.2
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	465.1
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	455.1
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	441.3
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	438.4
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	435.3
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	425.6
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	424.6
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	421.6
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	421.4
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	421.4
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	417.7
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	415.1
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	414.1
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	407.8
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	407.1
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	400.9
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	400.7
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	396.6
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	391.1
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	390.5
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	385.7
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	379.1
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	378.7
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	376.6
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	373.5
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	370.4
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	364.7
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	364.3
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	363.1
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	360.6
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	359.6
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	358.3
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	356.8
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	356.8
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	356.0
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	355.8
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	353.0
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	352.7
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	349.1
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	346.3
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	344.4
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	343.1
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	342.7
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	341.8
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	340.6
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	334.4
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	333.9
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	331.7
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	328.1
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	327.1
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	326.6
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	325.9
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	325.6
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	324.3
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	321.9
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	321.6
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	318.9
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	318.1
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	308.1
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	307.0
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	306.3
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	305.6
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	301.6
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	301.6
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	293.5
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	291.7
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	291.5
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	290.2
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	289.0
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	284.6
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	283.5
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	282.1
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	280.5
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	279.5
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	279.1
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	273.1
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	272.6
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	270.0
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	268.8
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	264.3
TCGA-14-1034-01A	60 years, female, dead, 485 days	263.7
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	263.5
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	263.1
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	262.4
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	261.1
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	257.3
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	253.8
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	251.2
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	249.2
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	247.0
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	238.3
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	235.1
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	234.2
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	232.6
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	232.1
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	230.4
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	222.5
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	220.6
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	218.5
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	218.3
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	212.3
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	211.7
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	211.2
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	210.7
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	197.8
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	195.7
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	195.7
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	190.7
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	183.5
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	174.8
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	161.2
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GLIOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA027407
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.