Expression of SPARC in pancreatic cancer

PANCREATIC CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

SPARC is not prognostic in pancreatic cancer

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 300.8
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

624.6

Number of samples

176

Samples

Sample	Description	FPKM
TCGA-IB-AAUV-01A	49 years, male, white, stage:iib, alive, 404 days	2554.7
TCGA-FB-AAPS-01A	62 years, female, white, stage:iib, alive, 228 days	2317.7
TCGA-IB-7893-01A	64 years, male, white, stage:iia, dead, 117 days	2161.3
TCGA-HZ-7925-01A	66 years, male, white, stage:iib, dead, 614 days	2107.7
TCGA-XD-AAUG-01A	66 years, female, white, stage:iv, alive, 420 days	1910.6
TCGA-YH-A8SY-01A	73 years, female, white, alive, 388 days	1837.0
TCGA-HZ-8001-01A	69 years, male, white, stage:iii, alive, 706 days	1778.4
TCGA-IB-7890-01A	73 years, male, stage:ib, dead, 598 days	1492.4
TCGA-HZ-7922-01A	61 years, female, white, stage:iib, alive, 4 days	1409.9
TCGA-3A-A9IC-01A	61 years, female, white, stage:iib, dead, 738 days	1336.3
TCGA-IB-7646-01A	60 years, male, white, stage:iib, dead, 145 days	1308.8
TCGA-HZ-A77Q-01A	55 years, female, white, stage:iib, alive, 33 days	1278.0
TCGA-IB-A5SQ-01A	56 years, female, white, stage:ib, dead, 219 days	1163.9
TCGA-HV-AA8V-01A	50 years, male, asian, stage:iib, alive, 920 days	1161.5
TCGA-2J-AAB8-01A	71 years, male, white, stage:iib, alive, 80 days	1137.6
TCGA-IB-7885-01A	78 years, female, white, stage:iib, alive, 1257 days	1137.1
TCGA-IB-AAUS-01A	84 years, female, white, stage:iib, alive, 225 days	1119.3
TCGA-YB-A89D-01A	59 years, male, white, stage:iib, alive, 350 days	1100.5
TCGA-HZ-8002-01A	61 years, male, white, stage:iib, dead, 366 days	1097.7
TCGA-IB-7654-01A	80 years, male, white, stage:iib, dead, 476 days	1081.4
TCGA-IB-7888-01A	66 years, female, black or african american, stage:iia, dead, 1332 days	1065.6
TCGA-HZ-8005-01A	81 years, male, white, stage:iib, dead, 120 days	1057.5
TCGA-IB-A5SS-01A	64 years, female, white, stage:iib, dead, 460 days	1056.4
TCGA-IB-7645-01A	44 years, female, stage:iib, dead, 1502 days	997.4
TCGA-RB-A7B8-01A	81 years, female, white, stage:iib, dead, 466 days	992.0
TCGA-3A-A9I7-01A	45 years, male, black or african american, stage:iib, alive, 1323 days	978.6
TCGA-RL-AAAS-01A	60 years, female, white, stage:ib, alive, 9 days	963.2
TCGA-2J-AABO-01A	43 years, male, white, stage:iib, alive, 440 days	959.0
TCGA-XN-A8T5-01A	53 years, female, white, stage:ib, alive, 720 days	954.6
TCGA-IB-AAUP-01A	68 years, male, white, stage:iib, alive, 431 days	940.3
TCGA-F2-A44H-01A	65 years, male, white, stage:iia, alive, 586 days	921.9
TCGA-IB-A5ST-01A	64 years, female, white, stage:iib, alive, 635 days	916.6
TCGA-US-A774-01A	76 years, female, white, stage:iib, dead, 695 days	894.0
TCGA-IB-A5SO-01A	71 years, male, white, stage:iib, dead, 365 days	884.5
TCGA-F2-7273-01A	54 years, male, black or african american, stage:iib, dead, 592 days	879.6
TCGA-XD-AAUL-01A	56 years, male, white, stage:iia, alive, 498 days	862.4
TCGA-HZ-7918-01A	72 years, male, white, stage:iib, alive, 969 days	850.8
TCGA-US-A77E-01A	73 years, male, white, stage:iib, dead, 430 days	849.8
TCGA-IB-7649-01A	73 years, female, stage:iib, dead, 467 days	836.7
TCGA-3A-A9IB-01A	69 years, female, white, stage:iib, dead, 224 days	830.7
TCGA-IB-7891-01A	49 years, female, white, stage:iib, dead, 913 days	825.8
TCGA-IB-7897-01A	54 years, female, white, stage:iib, dead, 486 days	821.4
TCGA-3A-A9IX-01A	40 years, male, white, stage:ia, alive, 1037 days	820.6
TCGA-IB-7887-01A	62 years, female, white, stage:iib, dead, 110 days	816.1
TCGA-HZ-A4BH-01A	75 years, male, white, stage:iib, alive, 194 days	781.9
TCGA-IB-7651-01A	64 years, female, white, stage:iib, dead, 603 days	780.6
TCGA-IB-7886-01A	80 years, male, white, stage:iib, dead, 123 days	773.9
TCGA-2J-AABE-01A	73 years, male, white, stage:iia, alive, 676 days	766.4
TCGA-H6-A45N-01A	88 years, female, white, stage:iib, dead, 421 days	765.6
TCGA-F2-7276-01A	64 years, male, white, stage:iib, dead, 216 days	760.7
TCGA-FB-A7DR-01A	48 years, male, asian, stage:iia, dead, 353 days	753.9
TCGA-XN-A8T3-01A	67 years, male, white, stage:ib, alive, 951 days	752.9
TCGA-HZ-7923-01A	65 years, male, white, stage:iia, alive, 314 days	744.4
TCGA-FB-A4P5-01A	69 years, female, white, stage:iib, dead, 179 days	742.8
TCGA-HZ-8519-01A	73 years, male, white, stage:ia, alive, 454 days	742.2
TCGA-IB-7652-01A	49 years, female, asian, stage:iib, alive, 1116 days	733.9
TCGA-HV-A5A4-01A	72 years, female, asian, stage:iia, alive, 232 days	730.1
TCGA-HZ-8636-01A	58 years, female, white, stage:iv, dead, 545 days	721.0
TCGA-3A-A9J0-01A	75 years, male, white, stage:iib, alive, 743 days	710.1
TCGA-2J-AABU-01A	56 years, male, white, stage:iib, dead, 277 days	701.9
TCGA-FB-AAQ3-01A	65 years, female, white, stage:iib, dead, 31 days	697.1
TCGA-2J-AAB6-01A	75 years, male, white, stage:iia, dead, 293 days	694.3
TCGA-FB-A545-01A	72 years, female, white, stage:iib, dead, 732 days	680.9
TCGA-US-A77J-01A	81 years, female, white, stage:iib, dead, 568 days	680.2
TCGA-HZ-A49H-01A	68 years, female, white, stage:iib, alive, 491 days	672.5
TCGA-IB-8127-01A	59 years, male, white, stage:iib, alive, 522 days	671.2
TCGA-IB-AAUR-01A	67 years, male, white, stage:iib, alive, 338 days	669.2
TCGA-HZ-8315-01A	54 years, female, white, stage:iia, dead, 299 days	667.3
TCGA-3A-A9IZ-01A	47 years, male, white, stage:iib, dead, 308 days	667.2
TCGA-IB-AAUQ-01A	50 years, male, white, stage:iib, dead, 183 days	655.4
TCGA-IB-7644-01A	65 years, female, white, stage:iv, dead, 394 days	650.6
TCGA-RB-AA9M-01A	43 years, male, white, stage:iib, alive, 286 days	649.9
TCGA-2J-AABA-01A	55 years, male, white, stage:iib, dead, 607 days	648.7
TCGA-OE-A75W-01A	75 years, male, white, stage:iia, dead, 267 days	647.0
TCGA-2J-AABP-01A	58 years, female, white, stage:iib, alive, 463 days	637.5
TCGA-M8-A5N4-01A	48 years, female, stage:iia, alive, 584 days	634.3
TCGA-FB-A5VM-01A	74 years, male, white, stage:ib, dead, 498 days	626.1
TCGA-HV-A5A6-01A	65 years, female, asian, stage:iib, dead, 2036 days	625.3
TCGA-H6-8124-01A	56 years, female, white, stage:iib, alive, 392 days	614.0
TCGA-XD-AAUH-01A	57 years, female, white, stage:iib, alive, 395 days	609.8
TCGA-PZ-A5RE-01A	44 years, female, white, stage:iib, dead, 470 days	602.7
TCGA-HV-A5A5-01A	61 years, female, asian, stage:iib, alive, 289 days	599.4
TCGA-IB-AAUT-01A	65 years, male, white, stage:iib, alive, 287 days	597.9
TCGA-FB-A4P6-01A	54 years, male, white, stage:iib, alive, 767 days	589.6
TCGA-F2-A8YN-01A	76 years, male, white, stage:iia, alive, 517 days	583.9
TCGA-3E-AAAY-01A	67 years, male, white, stage:iib, alive, 2285 days	583.1
TCGA-HZ-7919-01A	52 years, female, white, stage:iib, dead, 593 days	580.1
TCGA-HZ-7926-01A	57 years, male, black or african american, stage:iib, dead, 518 days	574.2
TCGA-S4-A8RP-01A	77 years, female, white, stage:iib, dead, 702 days	570.1
TCGA-3E-AAAZ-01A	71 years, male, white, stage:iia, dead, 2182 days	567.4
TCGA-HZ-A77P-01A	77 years, male, white, stage:iib, alive, 330 days	563.2
TCGA-F2-6879-01A	57 years, male, white, stage:iib, dead, 334 days	560.4
TCGA-2L-AAQL-01A	82 years, male, white, stage:iib, dead, 292 days	553.9
TCGA-2J-AABF-01A	73 years, male, white, stage:iib, dead, 691 days	525.0
TCGA-L1-A7W4-01A	48 years, female, white, stage:iib, dead, 278 days	517.3
TCGA-IB-AAUN-01A	74 years, female, white, stage:ib, dead, 144 days	516.7
TCGA-F2-A44G-01A	79 years, female, white, stage:iib, dead, 233 days	512.7
TCGA-2J-AAB9-01A	71 years, female, white, stage:iib, dead, 627 days	509.5
TCGA-IB-7889-01A	86 years, female, white, stage:iib, dead, 481 days	499.1
TCGA-3A-A9IU-01A	65 years, male, white, stage:iib, dead, 458 days	494.0
TCGA-Q3-A5QY-01A	58 years, male, white, stage:iib, alive, 416 days	487.5
TCGA-XD-AAUI-01A	50 years, female, white, stage:iib, dead, 366 days	484.9
TCGA-HZ-A49G-01A	58 years, female, white, stage:iib, alive, 660 days	482.2
TCGA-2J-AABI-01A	55 years, female, white, stage:iia, alive, 969 days	479.5
TCGA-2J-AABR-01A	60 years, female, white, stage:iia, alive, 438 days	473.0
TCGA-FB-AAPZ-01A	54 years, male, white, stage:iib, alive, 716 days	465.9
TCGA-HZ-8317-01A	69 years, female, white, stage:iib, dead, 378 days	460.5
TCGA-2L-AAQE-01A	56 years, male, white, stage:iib, dead, 684 days	460.0
TCGA-HZ-7920-01A	71 years, male, white, stage:ib, dead, 236 days	459.5
TCGA-HZ-8003-01A	65 years, female, white, stage:iib, dead, 596 days	459.2
TCGA-HZ-A4BK-01A	72 years, male, white, stage:iib, alive, 657 days	457.4
TCGA-2L-AAQJ-01A	49 years, female, white, stage:iii, dead, 394 days	453.0
TCGA-HZ-8637-01A	76 years, female, white, stage:iib, dead, 517 days	442.9
TCGA-H8-A6C1-01A	53 years, male, white, stage:iia, alive, 671 days	440.1
TCGA-FB-AAPY-01A	71 years, male, white, stage:iib, dead, 1059 days	422.6
TCGA-FB-AAPQ-01A	65 years, male, white, stage:iib, dead, 1130 days	422.5
TCGA-2L-AAQA-01A	76 years, male, white, stage:iib, dead, 143 days	420.6
TCGA-2J-AAB1-01A	65 years, male, white, stage:iib, dead, 66 days	416.7
TCGA-2L-AAQM-01A	52 years, male, white, stage:iib, alive, 1383 days	390.9
TCGA-HV-A7OL-01A	70 years, male, asian, stage:iia, alive, 252 days	390.0
TCGA-HZ-A49I-01A	77 years, male, white, stage:iib, dead, 308 days	382.3
TCGA-3A-A9IH-01A	66 years, female, white, stage:ia, alive, 1021 days	376.2
TCGA-2J-AABH-01A	61 years, male, white, stage:iia, alive, 1287 days	373.6
TCGA-3A-A9I5-01A	58 years, male, white, alive, 1794 days	357.5
TCGA-2J-AAB4-01A	48 years, male, white, stage:iib, alive, 729 days	355.6
TCGA-2J-AABT-01A	72 years, female, white, stage:iib, alive, 319 days	354.8
TCGA-HZ-A77O-01A	77 years, female, white, stage:iib, dead, 160 days	351.9
TCGA-HV-A5A3-01A	50 years, male, asian, stage:iia, dead, 128 days	340.7
TCGA-FB-AAQ6-01A	85 years, male, white, stage:ia, dead, 244 days	339.0
TCGA-S4-A8RO-01A	75 years, female, white, stage:iib, alive, 525 days	329.3
TCGA-2L-AAQI-01A	66 years, male, white, stage:iib, dead, 103 days	315.1
TCGA-F2-A7TX-01A	77 years, male, white, stage:iib, dead, 95 days	313.1
TCGA-HV-AA8X-01A	75 years, female, asian, stage:iib, dead, 532 days	305.4
TCGA-3A-A9I9-01A	67 years, male, white, stage:iia, dead, 634 days	303.8
TCGA-FB-AAQ1-01A	49 years, male, white, stage:iib, dead, 123 days	302.6
TCGA-IB-AAUO-01A	64 years, female, white, stage:iib, dead, 239 days	301.7
TCGA-3A-A9IV-01A	59 years, female, white, stage:ib, alive, 1103 days	299.9
TCGA-IB-AAUW-01A	63 years, female, white, stage:iib, dead, 230 days	297.5
TCGA-IB-AAUU-01A	35 years, male, white, stage:iib, alive, 245 days	273.1
TCGA-IB-8126-01A	80 years, female, white, stage:iii, alive, 462 days	270.7
TCGA-LB-A9Q5-01A	63 years, female, white, stage:iib, dead, 313 days	268.3
TCGA-IB-A7LX-01A	57 years, male, white, stage:iib, dead, 250 days	264.1
TCGA-Z5-AAPL-01A	74 years, female, white, stage:iia, alive, 467 days	263.8
TCGA-IB-A6UF-01A	63 years, male, white, stage:iib, alive, 666 days	259.3
TCGA-Q3-AA2A-01A	64 years, female, white, stage:ib, alive, 95 days	256.4
TCGA-IB-A7M4-01A	81 years, male, white, stage:iib, alive, 483 days	254.3
TCGA-LB-A8F3-01A	64 years, female, black or african american, stage:iia, alive, 379 days	246.2
TCGA-3A-A9IN-01A	62 years, female, white, stage:ib, alive, 2084 days	238.8
TCGA-3A-A9IJ-01A	65 years, male, white, stage:ib, alive, 1854 days	231.5
TCGA-FB-AAQ0-01A	68 years, male, white, stage:iia, dead, 473 days	227.2
TCGA-HZ-7289-01A	77 years, male, white, stage:iib, dead, 661 days	216.8
TCGA-HZ-8638-01A	84 years, female, white, stage:ia, dead, 151 days	213.2
TCGA-FB-AAQ2-01A	81 years, female, white, stage:iib, dead, 153 days	210.6
TCGA-HZ-A8P1-01A	81 years, male, white, stage:ib, alive, 7 days	207.6
TCGA-HZ-A9TJ-01A	70 years, male, white, stage:iv, alive, 603 days	205.2
TCGA-S4-A8RM-01A	67 years, male, white, stage:iib, alive, 737 days	176.0
TCGA-IB-A6UG-01A	65 years, male, white, stage:iib, dead, 41 days	171.7
TCGA-IB-AAUM-01A	76 years, male, white, stage:iib, alive, 8 days	168.4
TCGA-FB-AAPU-01A	41 years, female, asian, stage:iia, dead, 381 days	167.4
TCGA-FB-A78T-01A	71 years, female, white, stage:iib, dead, 375 days	166.6
TCGA-HZ-7924-01A	60 years, female, white, stage:iia, alive, 840 days	141.2
TCGA-2J-AABK-01A	71 years, male, white, stage:iib, alive, 484 days	137.6
TCGA-3A-A9IL-01A	39 years, female, white, stage:i, alive, 2741 days	132.5
TCGA-IB-A5SP-01A	77 years, male, white, stage:iia, alive, 482 days	132.2
TCGA-LB-A7SX-01A	74 years, female, black or african american, stage:iib, dead, 393 days	129.7
TCGA-US-A779-01A	54 years, female, white, stage:iib, dead, 511 days	119.8
TCGA-YY-A8LH-01A	61 years, female, white, stage:iib, alive, 2016 days	91.8
TCGA-US-A77G-01A	64 years, male, white, stage:iib, dead, 12 days	88.2
TCGA-3A-A9IR-01A	64 years, female, white, stage:ib, alive, 1542 days	75.9
TCGA-2J-AABV-01A	74 years, male, white, stage:iib, dead, 652 days	72.6
TCGA-3A-A9IO-01A	56 years, male, white, alive, 1942 days	65.2
TCGA-FB-AAPP-01A	71 years, male, white, stage:iib, dead, 485 days	59.7
TCGA-US-A776-01A	61 years, male, white, stage:iia, alive, 1216 days	59.7
TCGA-3A-A9IS-01A	67 years, male, white, stage:ib, alive, 998 days	40.5
TCGA-F2-6880-01A	70 years, male, white, stage:iib, alive, 289 days	23.8
TCGA-HV-A7OP-01A	72 years, male, asian, stage:iib, alive, 978 days	15.9
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PANCREATIC CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA002989	Antibody HPA003020	Antibody CAB002306
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details