Expression of NPC2 in testis cancer - The Human Protein Atlas

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NPC2

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TISSUE

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PATHOLOGY

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TESTIS CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

NPC2 is not prognostic in testis cancer

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 51.14
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

85.7

Number of samples

134

Samples

Sample	Description	FPKM
TCGA-ZM-AA0D-01A	34 years, male, white, stage:ia, alive, 848 days	229.2
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:iiic, alive, 1573 days	218.9
TCGA-2G-AAH3-01A	20 years, male, white, stage:i, alive, 1822 days	208.2
TCGA-VF-A8AA-01A	51 years, male, white, stage:i, alive, 1146 days	198.5
TCGA-ZM-AA0E-01A	39 years, male, white, stage:ia, alive, 811 days	188.3
TCGA-ZM-AA0H-01A	50 years, male, white, stage:is, alive, 1736 days	161.7
TCGA-2X-A9D5-01A	49 years, male, white, stage:i, alive, 435 days	160.3
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:ia, alive, 760 days	154.7
TCGA-XE-AAO6-01A	47 years, male, white, stage:ia, alive, 240 days	154.6
TCGA-2G-AAHL-01A	26 years, male, white, stage:i, alive, 7081 days	149.6
TCGA-ZM-AA0F-01A	35 years, male, white, stage:ia, alive, 681 days	147.2
TCGA-2G-AAGT-01A	30 years, male, white, stage:is, alive, 4406 days	145.6
TCGA-2G-AAHN-01A	32 years, male, white, stage:i, alive, 6445 days	144.9
TCGA-YU-A94I-01A	66 years, male, stage:ia, alive, 536 days	134.7
TCGA-XE-AANR-01A	24 years, male, white, stage:i, alive, 14 days	132.6
TCGA-XE-AAOJ-01A	24 years, male, white, stage:is, alive, 1550 days	131.9
TCGA-2G-AAHT-01A	32 years, male, white, stage:is, alive, 542 days	128.8
TCGA-XE-AANV-01A	52 years, male, stage:ib, alive, 1701 days	127.6
TCGA-2G-AAHA-01A	48 years, male, white, stage:ib, alive, 3349 days	126.7
TCGA-4K-AAAL-01A	31 years, male, white, stage:is, alive, 483 days	126.1
TCGA-YU-A90S-01A	26 years, male, white, stage:ia, alive, 971 days	125.3
TCGA-XE-AANJ-01A	39 years, male, white, stage:is, alive, 2007 days	123.9
TCGA-2G-AAFL-01A	35 years, male, white, stage:ib, alive, 750 days	121.7
TCGA-VF-A8AE-01A	39 years, male, white, stage:ia, alive, 727 days	119.3
TCGA-2G-AAH0-01A	30 years, male, white, stage:is, alive, 5477 days	118.1
TCGA-SN-A84X-01A	21 years, male, white, stage:is, alive, 312 days	116.4
TCGA-XE-AAO4-01A	40 years, male, white, stage:ia, alive, 367 days	114.6
TCGA-2G-AAFV-01A	31 years, male, white, stage:is, alive, 1389 days	114.6
TCGA-ZM-AA0B-01A	32 years, male, white, stage:ia, alive, 838 days	108.2
TCGA-4K-AA1H-01A	26 years, male, white, stage:ia, alive, 518 days	107.6
TCGA-VF-A8A9-01A	31 years, male, white, stage:ia, alive, 1119 days	106.5
TCGA-XE-AAOB-01A	27 years, male, white, stage:is, dead, 513 days	106.4
TCGA-2G-AAF1-01A	28 years, male, asian, stage:is, alive, 1403 days	104.6
TCGA-2G-AAEX-01A	38 years, male, white, stage:is, alive, 1259 days	104.5
TCGA-2G-AAHG-01A	25 years, male, white, stage:i, alive, 1819 days	103.2
TCGA-2G-AAFO-01A	33 years, male, white, stage:iia, alive, 685 days	102.6
TCGA-XE-AAOF-01A	50 years, male, asian, stage:ia, alive, 1268 days	101.6
TCGA-2G-AAFE-01A	37 years, male, white, stage:iia, alive, 4702 days	99.7
TCGA-VF-A8AC-01A	29 years, male, white, stage:ia, alive, 1083 days	99.2
TCGA-2G-AAG9-01A	25 years, male, white, stage:iiib, alive, 2234 days	99.1
TCGA-ZM-AA06-01A	45 years, male, white, stage:ib, alive, 1498 days	98.7
TCGA-2G-AAEW-01A	31 years, male, white, stage:is, dead, 618 days	98.3
TCGA-2G-AAFG-01A	30 years, male, white, stage:is, alive, 6183 days	98.2
TCGA-XE-A9SE-01A	35 years, male, white, stage:ia, alive, 708 days	97.7
TCGA-ZM-AA0N-01A	44 years, male, white, stage:ib, alive, 634 days	97.5
TCGA-2G-AAF6-01A	28 years, male, white, stage:is, alive, 3491 days	96.2
TCGA-XE-AAOD-01A	39 years, male, white, stage:ib, alive, 2058 days	96.2
TCGA-YU-A912-01A	34 years, male, black or african american, stage:iiic, alive, 866 days	95.9
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:i, alive, 13 days	93.1
TCGA-2G-AAH8-01A	45 years, male, white, stage:iiic, alive, 2248 days	92.6
TCGA-WZ-A7V5-01A	27 years, male, white, stage:i, alive, 1061 days	92.3
TCGA-SB-A6J6-01A	22 years, male, white, stage:ia, alive, 413 days	91.2
TCGA-YU-AA61-01A	29 years, male, white, stage:is, alive, 864 days	89.5
TCGA-2G-AAHP-01A	31 years, male, white, stage:is, alive, 5667 days	88.9
TCGA-2G-AAGZ-01A	27 years, male, white, stage:iiia, alive, 5233 days	88.7
TCGA-SO-A8JP-01A	29 years, male, white, stage:i, alive, 540 days	88.7
TCGA-2G-AAFM-01A	31 years, male, white, stage:iia, alive, 503 days	88.6
TCGA-2G-AAGM-01A	51 years, male, white, stage:is, alive, 3891 days	87.8
TCGA-2G-AAFY-01A	24 years, male, white, stage:iia, alive, 1099 days	85.8
TCGA-2G-AAFH-01A	38 years, male, white, stage:iib, alive, 1375 days	84.1
TCGA-ZM-AA05-01A	36 years, male, white, stage:iic, alive, 1126 days	82.5
TCGA-W4-A7U3-01A	26 years, male, white, alive, 149 days	82.1
TCGA-SB-A76C-01A	38 years, male, white, alive, 42 days	82.0
TCGA-XE-AAO3-01A	33 years, male, asian, stage:i, alive, 2857 days	82.0
TCGA-XY-A9T9-01A	37 years, male, white, stage:is, alive, 281 days	81.7
TCGA-SN-A6IS-01A	26 years, male, white, stage:is, alive, 496 days	81.5
TCGA-4K-AA1I-01A	26 years, male, white, stage:ia, alive, 3 days	79.5
TCGA-4K-AA1G-01A	34 years, male, white, stage:is, alive, 436 days	79.4
TCGA-2G-AAGG-01A	20 years, male, white, stage:iiic, alive, 2611 days	79.1
TCGA-WZ-A8D5-01A	38 years, male, white, alive, 774 days	78.4
TCGA-XE-A8H4-01A	23 years, male, white, stage:ia, alive, 559 days	78.2
TCGA-2G-AAF8-01A	33 years, male, white, stage:ia, alive, 3911 days	77.7
TCGA-WZ-A7V3-01A	20 years, male, white, stage:i, alive, 753 days	77.6
TCGA-2G-AAKD-01A	18 years, male, white, stage:iii, alive, 6340 days	77.4
TCGA-2G-AAHC-01A	33 years, male, white, stage:is, alive, 5539 days	76.9
TCGA-X3-A8G4-01A	33 years, male, white, stage:is, alive, 856 days	75.3
TCGA-2X-A9D6-01A	42 years, male, white, stage:i, alive, 607 days	74.4
TCGA-VF-A8AD-01A	36 years, male, white, stage:ib, alive, 1006 days	72.8
TCGA-YU-A90Q-01A	21 years, male, stage:ib, alive, 1964 days	71.7
TCGA-WZ-A7V4-01A	28 years, male, white, stage:i, alive, 894 days	71.3
TCGA-XY-A89B-01A	35 years, male, white, stage:ia, alive, 471 days	71.1
TCGA-2G-AAFZ-01A	32 years, male, white, stage:iii, alive, 1353 days	70.3
TCGA-2G-AAGA-01A	38 years, male, white, stage:iia, alive, 2439 days	69.3
TCGA-2G-AAG8-01A	21 years, male, white, stage:ib, alive, 2289 days	68.1
TCGA-XE-AAOC-01A	31 years, male, white, stage:ia, alive, 270 days	67.4
TCGA-2G-AAH4-01A	34 years, male, white, stage:ii, alive, 6210 days	66.1
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:ia, alive, 2938 days	64.7
TCGA-YU-A90P-01A	25 years, male, white, stage:ia, alive, 2069 days	64.0
TCGA-2G-AAL5-01A	31 years, male, white, stage:i, alive, 7437 days	63.5
TCGA-2G-AAFJ-01A	23 years, male, asian, alive, 792 days	62.8
TCGA-YU-A94D-01A	28 years, male, stage:iiib, alive, 2167 days	62.0
TCGA-2G-AAG3-01A	53 years, male, white, stage:is, alive, 1593 days	61.7
TCGA-2G-AAGP-01A	33 years, male, white, stage:iia, alive, 4018 days	60.3
TCGA-YU-A90W-01A	45 years, male, white, stage:ia, alive, 1113 days	59.6
TCGA-2G-AAGI-01A	33 years, male, white, stage:is, alive, 3137 days	59.4
TCGA-2G-AAKH-01A	19 years, male, white, stage:ii, alive, 6862 days	57.9
TCGA-S6-A8JX-01A	27 years, male, white, stage:ib, alive, 552 days	57.5
TCGA-2G-AAF4-01A	30 years, male, white, stage:i, alive, 2315 days	56.6
TCGA-2G-AAL7-01A	32 years, male, white, stage:is, alive, 3991 days	56.5
TCGA-XE-AANI-01A	37 years, male, white, stage:is, alive, 1041 days	56.3
TCGA-2G-AAG6-01A	24 years, male, white, stage:is, alive, 2231 days	55.6
TCGA-2G-AAKL-01A	26 years, male, white, stage:ii, alive, 7023 days	52.0
TCGA-S6-A8JW-01A	37 years, male, white, stage:is, alive, 698 days	52.0
TCGA-XE-A8H1-01A	24 years, male, white, stage:is, alive, 209 days	51.8
TCGA-2G-AAKG-01A	22 years, male, white, stage:i, alive, 6598 days	51.6
TCGA-2G-AAGO-01A	41 years, male, white, stage:is, alive, 4026 days	51.3
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:iiic, dead, 17 days	51.0
TCGA-2G-AAGV-01A	23 years, male, white, alive, 4527 days	50.5
TCGA-2G-AAGK-01A	20 years, male, white, stage:is, alive, 3621 days	50.3
TCGA-2G-AAKM-01A	14 years, male, white, stage:ii, dead, 6972 days	50.0
TCGA-2G-AALP-01A	43 years, male, white, stage:iiib, alive, 2645 days	49.2
TCGA-W4-A7U2-01A	26 years, male, white, alive, 1263 days	46.6
TCGA-2G-AAGF-01A	28 years, male, white, stage:is, alive, 2734 days	46.1
TCGA-2G-AAG5-01A	36 years, male, white, stage:is, alive, 2299 days	43.1
TCGA-2G-AAG0-01A	23 years, male, white, stage:is, alive, 1529 days	42.9
TCGA-2G-AAGE-01A	21 years, male, white, stage:is, alive, 2478 days	42.9
TCGA-S6-A8JY-01A	27 years, male, white, stage:is, alive, 278 days	42.0
TCGA-2G-AAGN-01A	41 years, male, white, stage:iiib, alive, 3656 days	41.9
TCGA-2G-AAGX-01A	22 years, male, white, stage:ia, alive, 5514 days	41.6
TCGA-2G-AAGW-01A	38 years, male, white, stage:is, alive, 4899 days	41.3
TCGA-2G-AAH2-01A	20 years, male, white, stage:is, alive, 6060 days	40.3
TCGA-XY-A8S2-01A	67 years, male, white, stage:i, alive, 672 days	39.6
TCGA-XE-A8H5-01A	29 years, male, stage:is, alive, 1217 days	38.8
TCGA-XY-A8S3-01B	24 years, male, white, stage:is, alive, 843 days	38.3
TCGA-SN-A84W-01A	30 years, male, white, stage:is, alive, 293 days	37.8
TCGA-VF-A8A8-01A	18 years, male, white, stage:ia, alive, 1131 days	37.6
TCGA-2G-AAGS-01A	39 years, male, white, stage:iiib, alive, 4816 days	36.6
TCGA-2G-AAGY-01A	28 years, male, white, stage:is, alive, 5329 days	36.3
TCGA-2G-AAGC-01A	28 years, male, white, stage:is, alive, 2585 days	35.9
TCGA-2G-AAG7-01A	33 years, male, white, stage:is, alive, 2475 days	35.7
TCGA-2G-AAFI-01A	41 years, male, white, stage:ib, alive, 675 days	35.5
TCGA-SN-A84Y-01A	18 years, male, white, stage:is, alive, 524 days	32.7
TCGA-2G-AAFN-01A	26 years, male, white, stage:iiib, alive, 773 days	31.2
TCGA-W4-A7U4-01A	23 years, male, white, alive, 738 days	31.1
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TESTIS CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA000835	Antibody CAB032888
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.