Expression of PRDX5 in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 686.84
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

586.6

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	1839.9
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	1811.5
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	1795.1
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	1761.5
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	1713.0
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	1655.5
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	1407.4
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	1299.7
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	1286.9
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	1267.3
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	1217.4
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	1189.2
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	1112.0
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	1040.9
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	1011.7
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	1006.4
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	985.8
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	984.7
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	977.2
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	953.7
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	944.6
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	938.4
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	896.2
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	896.0
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	892.7
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	890.8
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	880.6
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	857.5
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	843.6
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	831.5
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	826.7
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	815.7
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	811.5
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	790.5
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	783.4
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	780.3
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	779.5
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	774.4
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	773.1
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	772.7
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	748.4
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	742.9
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	736.5
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	731.6
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	726.0
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	721.9
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	715.7
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	712.9
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	708.4
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	704.2
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	687.3
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	686.4
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	670.7
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	661.6
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	657.0
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	655.1
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	654.5
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	650.6
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	637.9
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	629.3
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	626.9
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	621.7
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	618.3
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	616.8
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	612.3
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	601.6
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	594.5
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	587.7
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	585.0
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	574.9
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	566.1
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	550.9
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	543.3
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	540.8
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	533.7
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	533.3
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	530.2
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	525.3
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	517.7
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	515.8
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	506.5
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	501.9
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	498.6
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	490.2
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	489.9
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	469.8
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	466.1
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	465.3
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	463.3
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	454.2
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	450.9
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	448.6
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	442.0
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	431.4
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	429.6
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	426.7
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	426.5
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	426.3
TCGA-CL-4957-01A	79 years, female, dead, 425 days	419.7
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	413.0
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	412.5
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	411.6
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	408.9
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	408.1
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	378.2
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	376.9
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	372.3
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	369.7
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	367.3
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	367.1
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	362.8
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	358.3
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	354.3
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	345.3
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	339.9
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	337.7
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	335.6
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	335.6
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	331.5
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	325.1
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	325.1
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	325.0
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	304.1
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	297.1
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	287.6
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	281.3
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	279.8
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	268.4
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	266.2
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	263.8
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	258.9
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	257.8
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	255.5
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	253.7
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	251.8
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	250.5
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	241.1
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	235.1
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	231.2
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	229.9
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	223.1
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	218.9
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	206.0
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	200.1
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	193.9
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	189.4
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	178.8
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	177.7
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	171.9
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	170.7
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	167.7
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	163.9
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	163.3
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	159.4
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	138.3
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	125.9
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	124.8
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	103.9
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	88.3
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