Expression of CHI3L1 in glioma - The Human Protein Atlas

GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CHI3L1 is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 166.64
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1313.7

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	12014.8
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	7534.4
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	6950.1
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	6278.9
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	6162.4
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	5849.5
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	5631.1
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	5289.6
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	5005.7
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	4770.0
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	4766.2
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	4761.8
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	4213.3
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	4195.2
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	3834.0
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	3566.2
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	3509.7
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	3274.4
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	3149.3
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	3044.6
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	2932.2
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	2924.5
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	2912.0
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	2860.6
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	2860.0
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	2689.1
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	2505.6
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	2409.2
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	2372.2
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	2184.2
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	2130.2
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	1950.4
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	1943.3
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	1938.1
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	1766.3
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	1743.6
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	1728.3
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	1604.7
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	1572.6
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	1570.2
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	1555.4
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	1490.1
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	1451.4
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	1411.8
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	1361.8
TCGA-14-1034-01A	60 years, female, dead, 485 days	1361.5
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	1310.3
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	1309.1
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	1304.1
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	1227.5
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	1196.4
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	1157.7
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	1132.4
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	1115.7
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	1071.1
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	1052.6
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	1036.7
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	1010.0
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	1001.4
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	969.6
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	966.5
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	940.0
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	936.7
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	898.9
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	887.2
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	881.8
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	786.0
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	770.2
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	769.6
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	758.0
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	707.2
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	680.1
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	658.9
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	642.1
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	621.5
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	587.3
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	546.5
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	512.8
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	506.4
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	496.1
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	487.1
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	470.5
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	449.8
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	436.2
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	417.9
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	413.9
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	400.3
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	392.8
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	384.1
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	374.3
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	356.8
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	343.0
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	315.8
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	314.4
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	304.2
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	295.3
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	293.4
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	289.8
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	286.6
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	271.6
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	250.4
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	249.0
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	233.7
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	224.5
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	202.3
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	200.3
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	197.4
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	194.8
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	194.4
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	193.4
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	192.2
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	191.5
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	188.5
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	187.5
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	181.8
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	177.4
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	169.7
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	163.6
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	160.0
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	154.9
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	154.5
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	145.0
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	140.6
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	132.9
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	125.4
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	122.6
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	120.8
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	118.0
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	96.7
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	91.1
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	88.4
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	74.6
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	72.2
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	66.7
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	65.5
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	64.9
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	63.8
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	55.0
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	53.0
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	52.3
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	51.2
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	47.8
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	36.9
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	35.3
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	34.5
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	33.9
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	32.3
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	30.5
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	29.6
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	23.3
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	20.4
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	19.7
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	13.8
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GLIOMA - Protein expressionⁱ

Pending cancer tissue analysis