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TESTIS CANCER - Interactive survival scatter ploti
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
: Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A 5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A 5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
360.6
Number of samples
134
Samples
Sample
Description
FPKM
TCGA-2G-AAFM-01A
31 years, male, white, stage:iia, alive, 503 days
918.3
TCGA-2G-AAHL-01A
26 years, male, white, stage:i, alive, 7081 days
914.3
TCGA-WZ-A8D5-01A
38 years, male, white, alive, 774 days
832.4
TCGA-2G-AAKD-01A
18 years, male, white, stage:iii, alive, 6340 days
744.7
TCGA-4K-AAAL-01A
31 years, male, white, stage:is, alive, 483 days
651.2
TCGA-VF-A8A8-01A
18 years, male, white, stage:ia, alive, 1131 days
649.9
TCGA-XE-AANR-01A
24 years, male, white, stage:i, alive, 14 days
623.5
TCGA-XE-A9SE-01A
35 years, male, white, stage:ia, alive, 708 days
605.1
TCGA-2G-AAGF-01A
28 years, male, white, stage:is, alive, 2734 days
600.5
TCGA-ZM-AA06-01A
45 years, male, white, stage:ib, alive, 1498 days
599.9
TCGA-XE-AAO6-01A
47 years, male, white, stage:ia, alive, 240 days
591.3
TCGA-4K-AA1I-01A
26 years, male, white, stage:ia, alive, 3 days
578.4
TCGA-VF-A8AE-01A
39 years, male, white, stage:ia, alive, 727 days
568.2
TCGA-2G-AAF8-01A
33 years, male, white, stage:ia, alive, 3911 days
556.7
TCGA-ZM-AA0N-01A
44 years, male, white, stage:ib, alive, 634 days
550.7
TCGA-2G-AAL7-01A
32 years, male, white, stage:is, alive, 3991 days
543.0
TCGA-2G-AAGJ-01A
28 years, male, black or african american, stage:ia, alive, 2938 days
540.9
TCGA-2G-AAGO-01A
41 years, male, white, stage:is, alive, 4026 days
521.0
TCGA-2G-AAGW-01A
38 years, male, white, stage:is, alive, 4899 days
514.5
TCGA-XE-AAOD-01A
39 years, male, white, stage:ib, alive, 2058 days
506.3
TCGA-2G-AAFO-01A
33 years, male, white, stage:iia, alive, 685 days
482.9
TCGA-ZM-AA0F-01A
35 years, male, white, stage:ia, alive, 681 days
473.2
TCGA-2G-AAEX-01A
38 years, male, white, stage:is, alive, 1259 days
470.6
TCGA-2G-AAGZ-01A
27 years, male, white, stage:iiia, alive, 5233 days
469.0
TCGA-XE-AAOJ-01A
24 years, male, white, stage:is, alive, 1550 days
464.6
TCGA-2G-AAGA-01A
38 years, male, white, stage:iia, alive, 2439 days
463.6
TCGA-XE-AANJ-01A
39 years, male, white, stage:is, alive, 2007 days
458.9
TCGA-XE-A8H1-01A
24 years, male, white, stage:is, alive, 209 days
456.7
TCGA-SN-A84X-01A
21 years, male, white, stage:is, alive, 312 days
454.8
TCGA-2G-AAG3-01A
53 years, male, white, stage:is, alive, 1593 days
447.1
TCGA-XE-AAO3-01A
33 years, male, asian, stage:i, alive, 2857 days
442.0
TCGA-YU-A90W-01A
45 years, male, white, stage:ia, alive, 1113 days
440.7
TCGA-2G-AAH8-01A
45 years, male, white, stage:iiic, alive, 2248 days
439.6
TCGA-2G-AAHP-01A
31 years, male, white, stage:is, alive, 5667 days
430.2
TCGA-XE-AAO4-01A
40 years, male, white, stage:ia, alive, 367 days
427.5
TCGA-SB-A6J6-01A
22 years, male, white, stage:ia, alive, 413 days
426.9
TCGA-VF-A8A9-01A
31 years, male, white, stage:ia, alive, 1119 days
425.3
TCGA-2G-AAFN-01A
26 years, male, white, stage:iiib, alive, 773 days
424.5
TCGA-XE-A8H4-01A
23 years, male, white, stage:ia, alive, 559 days
417.4
TCGA-ZM-AA0B-01A
32 years, male, white, stage:ia, alive, 838 days
416.1
TCGA-YU-AA4L-01A
27 years, male, black or african american, stage:iiic, alive, 1573 days
408.8
TCGA-SO-A8JP-01A
29 years, male, white, stage:i, alive, 540 days
402.4
TCGA-2G-AAHN-01A
32 years, male, white, stage:i, alive, 6445 days
401.4
TCGA-2G-AAF6-01A
28 years, male, white, stage:is, alive, 3491 days
401.3
TCGA-SB-A76C-01A
38 years, male, white, alive, 42 days
400.8
TCGA-2G-AAKG-01A
22 years, male, white, stage:i, alive, 6598 days
390.6
TCGA-S6-A8JX-01A
27 years, male, white, stage:ib, alive, 552 days
390.5
TCGA-XE-A8H5-01A
29 years, male, stage:is, alive, 1217 days
386.8
TCGA-2G-AAFH-01A
38 years, male, white, stage:iib, alive, 1375 days
385.8
TCGA-VF-A8AA-01A
51 years, male, white, stage:i, alive, 1146 days
379.8
TCGA-2G-AAF4-01A
30 years, male, white, stage:i, alive, 2315 days
378.4
TCGA-2G-AAFL-01A
35 years, male, white, stage:ib, alive, 750 days
372.5
TCGA-2G-AAG8-01A
21 years, male, white, stage:ib, alive, 2289 days
365.5
TCGA-2G-AAEW-01A
31 years, male, white, stage:is, dead, 618 days
364.8
TCGA-2G-AAHA-01A
48 years, male, white, stage:ib, alive, 3349 days
363.9
TCGA-XE-AAOF-01A
50 years, male, asian, stage:ia, alive, 1268 days
361.2
TCGA-ZM-AA0H-01A
50 years, male, white, stage:is, alive, 1736 days
358.0
TCGA-4K-AA1G-01A
34 years, male, white, stage:is, alive, 436 days
357.1
TCGA-VF-A8AD-01A
36 years, male, white, stage:ib, alive, 1006 days
356.9
TCGA-2G-AAGE-01A
21 years, male, white, stage:is, alive, 2478 days
355.2
TCGA-XY-A89B-01A
35 years, male, white, stage:ia, alive, 471 days
353.1
TCGA-2G-AAH0-01A
30 years, male, white, stage:is, alive, 5477 days
351.7
TCGA-VF-A8AC-01A
29 years, male, white, stage:ia, alive, 1083 days
345.2
TCGA-S6-A8JY-01A
27 years, male, white, stage:is, alive, 278 days
339.8
TCGA-SN-A6IS-01A
26 years, male, white, stage:is, alive, 496 days
339.6
TCGA-SN-A84Y-01A
18 years, male, white, stage:is, alive, 524 days
336.9
TCGA-2G-AAG0-01A
23 years, male, white, stage:is, alive, 1529 days
336.1
TCGA-XE-AAOL-01A
38 years, male, black or african american, stage:i, alive, 13 days
334.4
TCGA-YU-A90Q-01A
21 years, male, stage:ib, alive, 1964 days
330.2
TCGA-2G-AAHT-01A
32 years, male, white, stage:is, alive, 542 days
329.1
TCGA-2G-AAFG-01A
30 years, male, white, stage:is, alive, 6183 days
328.9
TCGA-2G-AAHG-01A
25 years, male, white, stage:i, alive, 1819 days
327.8
TCGA-2G-AAFE-01A
37 years, male, white, stage:iia, alive, 4702 days
326.7
TCGA-2G-AAG9-01A
25 years, male, white, stage:iiib, alive, 2234 days
324.0
TCGA-W4-A7U4-01A
23 years, male, white, alive, 738 days
322.7
TCGA-2G-AAKM-01A
14 years, male, white, stage:ii, dead, 6972 days
319.0
TCGA-YU-A90Y-01A
23 years, male, black or african american, stage:iiic, dead, 17 days
318.2
TCGA-2G-AAFI-01A
41 years, male, white, stage:ib, alive, 675 days
317.3
TCGA-2G-AAKL-01A
26 years, male, white, stage:ii, alive, 7023 days
313.6
TCGA-ZM-AA0D-01A
34 years, male, white, stage:ia, alive, 848 days
313.5
TCGA-2G-AAGM-01A
51 years, male, white, stage:is, alive, 3891 days
305.6
TCGA-2G-AAG5-01A
36 years, male, white, stage:is, alive, 2299 days
304.7
TCGA-XE-AANV-01A
52 years, male, stage:ib, alive, 1701 days
303.4
TCGA-W4-A7U2-01A
26 years, male, white, alive, 1263 days
302.5
TCGA-2G-AAF1-01A
28 years, male, asian, stage:is, alive, 1403 days
298.7
TCGA-WZ-A7V5-01A
27 years, male, white, stage:i, alive, 1061 days
293.3
TCGA-2G-AAGN-01A
41 years, male, white, stage:iiib, alive, 3656 days
292.6
TCGA-YU-A90S-01A
26 years, male, white, stage:ia, alive, 971 days
291.3
TCGA-XY-A9T9-01A
37 years, male, white, stage:is, alive, 281 days
290.6
TCGA-WZ-A7V3-01A
20 years, male, white, stage:i, alive, 753 days
285.0
TCGA-YU-A94D-01A
28 years, male, stage:iiib, alive, 2167 days
284.7
TCGA-2G-AAHC-01A
33 years, male, white, stage:is, alive, 5539 days
279.4
TCGA-2G-AAGK-01A
20 years, male, white, stage:is, alive, 3621 days
278.7
TCGA-2G-AAFY-01A
24 years, male, white, stage:iia, alive, 1099 days
274.5
TCGA-2G-AAGS-01A
39 years, male, white, stage:iiib, alive, 4816 days
271.1
TCGA-2G-AALP-01A
43 years, male, white, stage:iiib, alive, 2645 days
270.5
TCGA-VF-A8AB-01A
31 years, male, black or african american, stage:ia, alive, 760 days
268.7
TCGA-YU-A90P-01A
25 years, male, white, stage:ia, alive, 2069 days
267.8
TCGA-2G-AAH3-01A
20 years, male, white, stage:i, alive, 1822 days
263.2
TCGA-XY-A8S2-01A
67 years, male, white, stage:i, alive, 672 days
258.6
TCGA-2G-AAH4-01A
34 years, male, white, stage:ii, alive, 6210 days
255.3
TCGA-YU-A912-01A
34 years, male, black or african american, stage:iiic, alive, 866 days
254.3
TCGA-ZM-AA05-01A
36 years, male, white, stage:iic, alive, 1126 days
252.0
TCGA-4K-AA1H-01A
26 years, male, white, stage:ia, alive, 518 days
250.6
TCGA-2G-AAFZ-01A
32 years, male, white, stage:iii, alive, 1353 days
246.6
TCGA-YU-A94I-01A
66 years, male, stage:ia, alive, 536 days
245.2
TCGA-X3-A8G4-01A
33 years, male, white, stage:is, alive, 856 days
242.0
TCGA-2G-AAKH-01A
19 years, male, white, stage:ii, alive, 6862 days
241.3
TCGA-XY-A8S3-01B
24 years, male, white, stage:is, alive, 843 days
231.3
TCGA-XE-AAOB-01A
27 years, male, white, stage:is, dead, 513 days
230.8
TCGA-2G-AAGT-01A
30 years, male, white, stage:is, alive, 4406 days
220.0
TCGA-2G-AAFJ-01A
23 years, male, asian, alive, 792 days
217.2
TCGA-2G-AAGC-01A
28 years, male, white, stage:is, alive, 2585 days
216.4
TCGA-2G-AAGI-01A
33 years, male, white, stage:is, alive, 3137 days
215.5
TCGA-2G-AAGG-01A
20 years, male, white, stage:iiic, alive, 2611 days
213.1
TCGA-2G-AAL5-01A
31 years, male, white, stage:i, alive, 7437 days
210.4
TCGA-2G-AAFV-01A
31 years, male, white, stage:is, alive, 1389 days
210.2
TCGA-2G-AAGX-01A
22 years, male, white, stage:ia, alive, 5514 days
209.6
TCGA-YU-AA61-01A
29 years, male, white, stage:is, alive, 864 days
201.6
TCGA-XE-AAOC-01A
31 years, male, white, stage:ia, alive, 270 days
200.7
TCGA-S6-A8JW-01A
37 years, male, white, stage:is, alive, 698 days
198.1
TCGA-2G-AAG7-01A
33 years, male, white, stage:is, alive, 2475 days
196.7
TCGA-2X-A9D6-01A
42 years, male, white, stage:i, alive, 607 days
190.9
TCGA-2X-A9D5-01A
49 years, male, white, stage:i, alive, 435 days
190.8
TCGA-WZ-A7V4-01A
28 years, male, white, stage:i, alive, 894 days
184.2
TCGA-2G-AAH2-01A
20 years, male, white, stage:is, alive, 6060 days
180.3
TCGA-ZM-AA0E-01A
39 years, male, white, stage:ia, alive, 811 days
180.3
TCGA-XE-AANI-01A
37 years, male, white, stage:is, alive, 1041 days
158.8
TCGA-2G-AAGV-01A
23 years, male, white, alive, 4527 days
154.3
TCGA-SN-A84W-01A
30 years, male, white, stage:is, alive, 293 days
153.3
TCGA-W4-A7U3-01A
26 years, male, white, alive, 149 days
152.2
TCGA-2G-AAG6-01A
24 years, male, white, stage:is, alive, 2231 days
147.0
TCGA-2G-AAGP-01A
33 years, male, white, stage:iia, alive, 4018 days
137.1
TCGA-2G-AAGY-01A
28 years, male, white, stage:is, alive, 5329 days
122.8
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TESTIS CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells.