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PANCREATIC CANCER - Interactive survival scatter ploti
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
: Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A 5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A 5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
780.1
Number of samples
176
Samples
Sample
Description
FPKM
TCGA-HV-A7OP-01A
72 years, male, asian, stage:iib, alive, 978 days
3666.5
TCGA-HZ-A9TJ-01A
70 years, male, white, stage:iv, alive, 603 days
1996.2
TCGA-Q3-A5QY-01A
58 years, male, white, stage:iib, alive, 416 days
1513.5
TCGA-IB-7889-01A
86 years, female, white, stage:iib, dead, 481 days
1422.7
TCGA-Z5-AAPL-01A
74 years, female, white, stage:iia, alive, 467 days
1396.7
TCGA-OE-A75W-01A
75 years, male, white, stage:iia, dead, 267 days
1382.0
TCGA-HV-A7OL-01A
70 years, male, asian, stage:iia, alive, 252 days
1359.8
TCGA-IB-7886-01A
80 years, male, white, stage:iib, dead, 123 days
1289.2
TCGA-HZ-8001-01A
69 years, male, white, stage:iii, alive, 706 days
1276.6
TCGA-FB-A5VM-01A
74 years, male, white, stage:ib, dead, 498 days
1276.5
TCGA-US-A77J-01A
81 years, female, white, stage:iib, dead, 568 days
1268.5
TCGA-2J-AABV-01A
74 years, male, white, stage:iib, dead, 652 days
1267.4
TCGA-RL-AAAS-01A
60 years, female, white, stage:ib, alive, 9 days
1252.9
TCGA-IB-A6UG-01A
65 years, male, white, stage:iib, dead, 41 days
1251.0
TCGA-FB-AAQ3-01A
65 years, female, white, stage:iib, dead, 31 days
1215.4
TCGA-US-A776-01A
61 years, male, white, stage:iia, alive, 1216 days
1184.2
TCGA-FB-AAQ6-01A
85 years, male, white, stage:ia, dead, 244 days
1165.7
TCGA-IB-AAUR-01A
67 years, male, white, stage:iib, alive, 338 days
1157.7
TCGA-IB-A7M4-01A
81 years, male, white, stage:iib, alive, 483 days
1147.3
TCGA-IB-7644-01A
65 years, female, white, stage:iv, dead, 394 days
1140.0
TCGA-3A-A9IN-01A
62 years, female, white, stage:ib, alive, 2084 days
1097.0
TCGA-2L-AAQL-01A
82 years, male, white, stage:iib, dead, 292 days
1090.5
TCGA-3A-A9I5-01A
58 years, male, white, alive, 1794 days
1083.9
TCGA-US-A779-01A
54 years, female, white, stage:iib, dead, 511 days
1078.8
TCGA-3E-AAAZ-01A
71 years, male, white, stage:iia, dead, 2182 days
1071.9
TCGA-LB-A8F3-01A
64 years, female, black or african american, stage:iia, alive, 379 days
1058.2
TCGA-FB-AAPZ-01A
54 years, male, white, stage:iib, alive, 716 days
1057.5
TCGA-YY-A8LH-01A
61 years, female, white, stage:iib, alive, 2016 days
1015.6
TCGA-HZ-A49H-01A
68 years, female, white, stage:iib, alive, 491 days
1015.5
TCGA-FB-AAQ2-01A
81 years, female, white, stage:iib, dead, 153 days
1014.7
TCGA-HZ-7289-01A
77 years, male, white, stage:iib, dead, 661 days
1009.5
TCGA-IB-AAUP-01A
68 years, male, white, stage:iib, alive, 431 days
1008.2
TCGA-FB-AAQ0-01A
68 years, male, white, stage:iia, dead, 473 days
1006.4
TCGA-FB-AAPY-01A
71 years, male, white, stage:iib, dead, 1059 days
991.1
TCGA-2J-AABK-01A
71 years, male, white, stage:iib, alive, 484 days
977.2
TCGA-IB-7887-01A
62 years, female, white, stage:iib, dead, 110 days
960.1
TCGA-IB-A5ST-01A
64 years, female, white, stage:iib, alive, 635 days
956.6
TCGA-F2-A7TX-01A
77 years, male, white, stage:iib, dead, 95 days
953.6
TCGA-2J-AABI-01A
55 years, female, white, stage:iia, alive, 969 days
950.8
TCGA-XN-A8T5-01A
53 years, female, white, stage:ib, alive, 720 days
918.3
TCGA-XD-AAUH-01A
57 years, female, white, stage:iib, alive, 395 days
895.4
TCGA-HV-A5A3-01A
50 years, male, asian, stage:iia, dead, 128 days
892.3
TCGA-Q3-AA2A-01A
64 years, female, white, stage:ib, alive, 95 days
891.4
TCGA-2J-AAB6-01A
75 years, male, white, stage:iia, dead, 293 days
874.4
TCGA-FB-A78T-01A
71 years, female, white, stage:iib, dead, 375 days
873.1
TCGA-3A-A9IJ-01A
65 years, male, white, stage:ib, alive, 1854 days
870.4
TCGA-IB-7891-01A
49 years, female, white, stage:iib, dead, 913 days
866.2
TCGA-HZ-7922-01A
61 years, female, white, stage:iib, alive, 4 days
838.2
TCGA-IB-A7LX-01A
57 years, male, white, stage:iib, dead, 250 days
828.1
TCGA-2L-AAQE-01A
56 years, male, white, stage:iib, dead, 684 days
825.2
TCGA-IB-A5SP-01A
77 years, male, white, stage:iia, alive, 482 days
823.6
TCGA-IB-7888-01A
66 years, female, black or african american, stage:iia, dead, 1332 days
820.0
TCGA-HZ-A77O-01A
77 years, female, white, stage:iib, dead, 160 days
815.8
TCGA-3A-A9IL-01A
39 years, female, white, stage:i, alive, 2741 days
815.5
TCGA-2J-AAB9-01A
71 years, female, white, stage:iib, dead, 627 days
814.7
TCGA-IB-A6UF-01A
63 years, male, white, stage:iib, alive, 666 days
812.0
TCGA-FB-A4P5-01A
69 years, female, white, stage:iib, dead, 179 days
810.1
TCGA-S4-A8RO-01A
75 years, female, white, stage:iib, alive, 525 days
805.5
TCGA-2L-AAQM-01A
52 years, male, white, stage:iib, alive, 1383 days
802.9
TCGA-H6-8124-01A
56 years, female, white, stage:iib, alive, 392 days
800.3
TCGA-F2-A44G-01A
79 years, female, white, stage:iib, dead, 233 days
796.6
TCGA-IB-AAUT-01A
65 years, male, white, stage:iib, alive, 287 days
790.4
TCGA-2J-AABH-01A
61 years, male, white, stage:iia, alive, 1287 days
789.5
TCGA-3A-A9IU-01A
65 years, male, white, stage:iib, dead, 458 days
788.4
TCGA-2J-AAB1-01A
65 years, male, white, stage:iib, dead, 66 days
787.9
TCGA-3E-AAAY-01A
67 years, male, white, stage:iib, alive, 2285 days
787.8
TCGA-HZ-A8P1-01A
81 years, male, white, stage:ib, alive, 7 days
785.6
TCGA-2J-AABP-01A
58 years, female, white, stage:iib, alive, 463 days
785.2
TCGA-IB-AAUV-01A
49 years, male, white, stage:iib, alive, 404 days
782.2
TCGA-3A-A9IB-01A
69 years, female, white, stage:iib, dead, 224 days
771.1
TCGA-F2-A44H-01A
65 years, male, white, stage:iia, alive, 586 days
769.1
TCGA-2J-AAB8-01A
71 years, male, white, stage:iib, alive, 80 days
767.5
TCGA-F2-A8YN-01A
76 years, male, white, stage:iia, alive, 517 days
767.4
TCGA-2L-AAQI-01A
66 years, male, white, stage:iib, dead, 103 days
767.2
TCGA-3A-A9IX-01A
40 years, male, white, stage:ia, alive, 1037 days
765.0
TCGA-IB-7649-01A
73 years, female, stage:iib, dead, 467 days
764.7
TCGA-3A-A9J0-01A
75 years, male, white, stage:iib, alive, 743 days
756.7
TCGA-HZ-7920-01A
71 years, male, white, stage:ib, dead, 236 days
744.2
TCGA-3A-A9IR-01A
64 years, female, white, stage:ib, alive, 1542 days
742.6
TCGA-FB-AAPU-01A
41 years, female, asian, stage:iia, dead, 381 days
739.6
TCGA-F2-6879-01A
57 years, male, white, stage:iib, dead, 334 days
738.4
TCGA-XD-AAUG-01A
66 years, female, white, stage:iv, alive, 420 days
737.5
TCGA-2L-AAQA-01A
76 years, male, white, stage:iib, dead, 143 days
736.5
TCGA-H8-A6C1-01A
53 years, male, white, stage:iia, alive, 671 days
734.9
TCGA-2J-AABA-01A
55 years, male, white, stage:iib, dead, 607 days
725.5
TCGA-HZ-8002-01A
61 years, male, white, stage:iib, dead, 366 days
720.9
TCGA-3A-A9IO-01A
56 years, male, white, alive, 1942 days
716.6
TCGA-IB-AAUW-01A
63 years, female, white, stage:iib, dead, 230 days
711.3
TCGA-FB-AAPS-01A
62 years, female, white, stage:iib, alive, 228 days
706.6
TCGA-IB-AAUQ-01A
50 years, male, white, stage:iib, dead, 183 days
701.9
TCGA-IB-AAUO-01A
64 years, female, white, stage:iib, dead, 239 days
701.4
TCGA-RB-AA9M-01A
43 years, male, white, stage:iib, alive, 286 days
694.1
TCGA-H6-A45N-01A
88 years, female, white, stage:iib, dead, 421 days
687.1
TCGA-IB-7654-01A
80 years, male, white, stage:iib, dead, 476 days
685.6
TCGA-US-A774-01A
76 years, female, white, stage:iib, dead, 695 days
684.7
TCGA-IB-AAUM-01A
76 years, male, white, stage:iib, alive, 8 days
682.7
TCGA-FB-AAQ1-01A
49 years, male, white, stage:iib, dead, 123 days
676.5
TCGA-HZ-7924-01A
60 years, female, white, stage:iia, alive, 840 days
673.6
TCGA-YB-A89D-01A
59 years, male, white, stage:iib, alive, 350 days
671.4
TCGA-XN-A8T3-01A
67 years, male, white, stage:ib, alive, 951 days
666.9
TCGA-FB-A545-01A
72 years, female, white, stage:iib, dead, 732 days
664.0
TCGA-XD-AAUI-01A
50 years, female, white, stage:iib, dead, 366 days
663.8
TCGA-IB-A5SQ-01A
56 years, female, white, stage:ib, dead, 219 days
659.3
TCGA-HZ-7925-01A
66 years, male, white, stage:iib, dead, 614 days
656.1
TCGA-IB-AAUN-01A
74 years, female, white, stage:ib, dead, 144 days
656.0
TCGA-IB-AAUS-01A
84 years, female, white, stage:iib, alive, 225 days
654.9
TCGA-3A-A9IZ-01A
47 years, male, white, stage:iib, dead, 308 days
652.4
TCGA-2J-AABR-01A
60 years, female, white, stage:iia, alive, 438 days
651.2
TCGA-HZ-7918-01A
72 years, male, white, stage:iib, alive, 969 days
650.1
TCGA-HZ-7923-01A
65 years, male, white, stage:iia, alive, 314 days
649.5
TCGA-F2-7273-01A
54 years, male, black or african american, stage:iib, dead, 592 days
646.9
TCGA-3A-A9I9-01A
67 years, male, white, stage:iia, dead, 634 days
645.3
TCGA-IB-A5SO-01A
71 years, male, white, stage:iib, dead, 365 days
644.8
TCGA-PZ-A5RE-01A
44 years, female, white, stage:iib, dead, 470 days
643.8
TCGA-IB-7651-01A
64 years, female, white, stage:iib, dead, 603 days
641.6
TCGA-IB-8127-01A
59 years, male, white, stage:iib, alive, 522 days
640.6
TCGA-IB-7645-01A
44 years, female, stage:iib, dead, 1502 days
637.7
TCGA-FB-AAPP-01A
71 years, male, white, stage:iib, dead, 485 days
633.5
TCGA-HZ-A77P-01A
77 years, male, white, stage:iib, alive, 330 days
632.7
TCGA-2J-AABE-01A
73 years, male, white, stage:iia, alive, 676 days
624.7
TCGA-3A-A9I7-01A
45 years, male, black or african american, stage:iib, alive, 1323 days
624.0
TCGA-3A-A9IH-01A
66 years, female, white, stage:ia, alive, 1021 days
623.7
TCGA-2L-AAQJ-01A
49 years, female, white, stage:iii, dead, 394 days
621.1
TCGA-F2-7276-01A
64 years, male, white, stage:iib, dead, 216 days
620.3
TCGA-LB-A7SX-01A
74 years, female, black or african american, stage:iib, dead, 393 days
613.7
TCGA-HZ-7926-01A
57 years, male, black or african american, stage:iib, dead, 518 days
612.0
TCGA-F2-6880-01A
70 years, male, white, stage:iib, alive, 289 days
610.3
TCGA-HZ-A77Q-01A
55 years, female, white, stage:iib, alive, 33 days
604.5
TCGA-HZ-8519-01A
73 years, male, white, stage:ia, alive, 454 days
603.5
TCGA-HZ-A4BK-01A
72 years, male, white, stage:iib, alive, 657 days
603.4
TCGA-S4-A8RM-01A
67 years, male, white, stage:iib, alive, 737 days
603.2
TCGA-2J-AABF-01A
73 years, male, white, stage:iib, dead, 691 days
601.6
TCGA-LB-A9Q5-01A
63 years, female, white, stage:iib, dead, 313 days
598.1
TCGA-HZ-A49G-01A
58 years, female, white, stage:iib, alive, 660 days
593.2
TCGA-3A-A9IC-01A
61 years, female, white, stage:iib, dead, 738 days
592.7
TCGA-2J-AABO-01A
43 years, male, white, stage:iib, alive, 440 days
591.9
TCGA-HV-AA8V-01A
50 years, male, asian, stage:iib, alive, 920 days
591.6
TCGA-HV-A5A4-01A
72 years, female, asian, stage:iia, alive, 232 days
588.5
TCGA-S4-A8RP-01A
77 years, female, white, stage:iib, dead, 702 days
588.5
TCGA-YH-A8SY-01A
73 years, female, white, alive, 388 days
577.9
TCGA-RB-A7B8-01A
81 years, female, white, stage:iib, dead, 466 days
574.4
TCGA-FB-A4P6-01A
54 years, male, white, stage:iib, alive, 767 days
562.9
TCGA-HZ-7919-01A
52 years, female, white, stage:iib, dead, 593 days
542.0
TCGA-HZ-8005-01A
81 years, male, white, stage:iib, dead, 120 days
541.2
TCGA-IB-7897-01A
54 years, female, white, stage:iib, dead, 486 days
539.3
TCGA-3A-A9IV-01A
59 years, female, white, stage:ib, alive, 1103 days
535.7
TCGA-HZ-8637-01A
76 years, female, white, stage:iib, dead, 517 days
524.0
TCGA-HV-A5A5-01A
61 years, female, asian, stage:iib, alive, 289 days
523.8
TCGA-IB-7890-01A
73 years, male, stage:ib, dead, 598 days
514.9
TCGA-HV-A5A6-01A
65 years, female, asian, stage:iib, dead, 2036 days
512.2
TCGA-US-A77E-01A
73 years, male, white, stage:iib, dead, 430 days
508.1
TCGA-2J-AABU-01A
56 years, male, white, stage:iib, dead, 277 days
504.7
TCGA-HZ-8315-01A
54 years, female, white, stage:iia, dead, 299 days
504.5
TCGA-IB-7893-01A
64 years, male, white, stage:iia, dead, 117 days
501.5
TCGA-IB-7885-01A
78 years, female, white, stage:iib, alive, 1257 days
497.9
TCGA-2J-AABT-01A
72 years, female, white, stage:iib, alive, 319 days
489.6
TCGA-HZ-8317-01A
69 years, female, white, stage:iib, dead, 378 days
489.0
TCGA-HZ-A49I-01A
77 years, male, white, stage:iib, dead, 308 days
481.8
TCGA-HZ-8638-01A
84 years, female, white, stage:ia, dead, 151 days
480.2
TCGA-3A-A9IS-01A
67 years, male, white, stage:ib, alive, 998 days
477.9
TCGA-L1-A7W4-01A
48 years, female, white, stage:iib, dead, 278 days
468.2
TCGA-HZ-8636-01A
58 years, female, white, stage:iv, dead, 545 days
467.5
TCGA-IB-8126-01A
80 years, female, white, stage:iii, alive, 462 days
453.4
TCGA-2J-AAB4-01A
48 years, male, white, stage:iib, alive, 729 days
451.0
TCGA-HZ-A4BH-01A
75 years, male, white, stage:iib, alive, 194 days
446.5
TCGA-XD-AAUL-01A
56 years, male, white, stage:iia, alive, 498 days
446.5
TCGA-HV-AA8X-01A
75 years, female, asian, stage:iib, dead, 532 days
444.3
TCGA-FB-AAPQ-01A
65 years, male, white, stage:iib, dead, 1130 days
441.3
TCGA-FB-A7DR-01A
48 years, male, asian, stage:iia, dead, 353 days
435.1
TCGA-IB-A5SS-01A
64 years, female, white, stage:iib, dead, 460 days
413.0
TCGA-US-A77G-01A
64 years, male, white, stage:iib, dead, 12 days
406.7
TCGA-IB-7652-01A
49 years, female, asian, stage:iib, alive, 1116 days
406.5
TCGA-IB-AAUU-01A
35 years, male, white, stage:iib, alive, 245 days
406.2
TCGA-HZ-8003-01A
65 years, female, white, stage:iib, dead, 596 days
396.2
TCGA-M8-A5N4-01A
48 years, female, stage:iia, alive, 584 days
376.1
TCGA-IB-7646-01A
60 years, male, white, stage:iib, dead, 145 days
312.2
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PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells.