Expression of LCN2 in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 209.6
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

456.8

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	4335.1
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	3771.1
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	3090.5
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	2876.6
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	2716.8
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	2234.1
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	2093.4
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	2075.1
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	1993.4
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	1676.5
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	1517.5
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	1514.3
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	1294.3
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	1225.3
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	1191.2
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	1162.0
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	1155.0
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	1117.0
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	1018.7
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	934.0
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	800.4
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	750.3
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	743.3
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	742.1
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	710.4
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	703.8
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	690.7
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	680.8
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	671.7
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	663.8
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	595.2
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	588.1
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	574.5
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	548.1
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	546.6
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	519.6
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	512.6
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	501.8
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	501.1
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	498.3
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	489.2
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	475.6
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	469.5
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	457.2
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	453.7
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	431.5
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	425.7
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	421.0
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	401.6
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	398.9
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	393.6
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	383.2
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	382.7
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	357.4
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	347.3
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	344.3
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	327.6
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	320.7
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	317.5
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	315.4
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	314.2
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	312.4
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	306.4
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	303.7
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	303.1
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	301.9
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	290.9
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	285.7
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	271.8
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	270.2
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	269.6
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	266.7
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	258.9
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	256.6
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	256.2
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	252.3
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	240.6
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	237.6
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	233.1
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	230.2
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	229.3
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	226.6
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	223.9
TCGA-CL-4957-01A	79 years, female, dead, 425 days	222.4
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	218.9
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	214.1
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	210.9
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	208.3
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	204.1
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	202.3
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	196.0
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	191.6
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	180.5
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	178.5
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	177.4
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	166.6
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	160.1
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	159.0
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	153.2
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	149.7
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	141.2
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	130.6
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	127.5
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	126.8
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	125.6
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	123.9
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	120.0
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	114.6
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	112.5
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	112.3
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	111.6
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	106.1
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	103.4
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	100.7
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	100.6
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	98.3
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	92.6
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	79.4
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	77.8
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	75.6
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	73.9
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	72.9
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	71.5
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	71.0
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	67.0
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	64.6
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	62.8
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	62.3
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	62.0
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	60.8
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	60.8
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	59.8
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	59.7
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	57.6
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	54.5
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	53.8
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	53.5
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	47.5
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	47.1
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	45.8
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	45.2
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	44.3
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	34.6
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	34.5
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	32.1
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	31.9
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	29.9
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	26.9
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	24.6
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	23.4
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	20.5
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	19.4
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	18.7
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	15.2
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	14.9
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	13.1
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	12.8
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	9.4
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	6.3
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