Expression of DEFB1 in renal cancer - The Human Protein Atlas

KIDNEY CHROMOPHOBE (KICH) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 4102.53
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

2832.2

Number of samples

Samples

Sample	Description	FPKM
TCGA-KM-8439-01A	30 years, male, white, stage:i, alive, 708 days	13754.6
TCGA-KM-8639-01A	67 years, male, white, stage:i, alive, 953 days	8924.7
TCGA-KM-8441-01A	61 years, female, white, stage:i, alive, 876 days	8504.6
TCGA-KN-8428-01A	71 years, male, white, stage:ii, dead, 1590 days	6781.7
TCGA-KL-8326-01A	69 years, male, white, stage:iii, alive, 3322 days	6124.7
TCGA-KN-8437-01A	42 years, female, white, stage:i, alive, 3068 days	5615.7
TCGA-KL-8343-01A	72 years, male, white, stage:iii, dead, 2172 days	5147.7
TCGA-KO-8408-01A	47 years, male, white, stage:iii, dead, 507 days	5090.5
TCGA-KL-8328-01A	60 years, male, white, stage:ii, alive, 3127 days	4968.1
TCGA-KO-8409-01A	69 years, male, white, stage:ii, alive, 3180 days	4831.1
TCGA-KM-8438-01A	45 years, female, white, stage:ii, alive, 4622 days	4717.8
TCGA-KM-8476-01A	47 years, male, white, stage:i, alive, 3745 days	4426.6
TCGA-KM-8477-01A	56 years, male, white, stage:i, alive, 1553 days	4420.8
TCGA-KL-8339-01A	67 years, male, white, stage:iv, dead, 855 days	4415.3
TCGA-KL-8334-01A	37 years, female, white, stage:iii, alive, 2949 days	3789.8
TCGA-KL-8345-01A	75 years, male, white, stage:iii, alive, 1665 days	3523.1
TCGA-KL-8330-01A	44 years, female, black or african american, stage:ii, alive, 3304 days	3288.8
TCGA-KM-8443-01A	58 years, male, white, stage:ii, alive, 1520 days	3138.6
TCGA-KL-8323-01A	57 years, female, white, stage:iii, dead, 1158 days	3106.1
TCGA-KL-8331-01A	48 years, female, white, stage:ii, alive, 3010 days	3079.6
TCGA-KN-8434-01A	65 years, female, white, stage:ii, alive, 1797 days	3056.7
TCGA-KO-8403-01A	49 years, male, white, stage:i, alive, 3208 days	3017.4
TCGA-KN-8418-01A	41 years, female, white, stage:ii, alive, 3935 days	2991.9
TCGA-KO-8415-01A	44 years, female, white, stage:i, alive, 2939 days	2863.2
TCGA-KO-8405-01A	29 years, male, white, stage:iii, alive, 3056 days	2772.9
TCGA-KL-8332-01A	55 years, male, white, stage:i, alive, 2582 days	2756.7
TCGA-KL-8333-01A	69 years, male, white, stage:ii, alive, 2991 days	2585.2
TCGA-KL-8340-01A	34 years, male, white, stage:ii, alive, 2024 days	2557.3
TCGA-KN-8431-01A	35 years, female, stage:ii, alive, 588 days	2489.1
TCGA-KL-8329-01A	57 years, female, asian, stage:i, alive, 2752 days	2443.9
TCGA-KO-8406-01A	17 years, female, white, stage:i, alive, 3145 days	2433.2
TCGA-KM-8440-01A	37 years, male, black or african american, stage:iii, alive, 1366 days	2376.8
TCGA-KO-8407-01A	42 years, male, white, stage:ii, alive, 2820 days	2335.7
TCGA-KO-8410-01A	74 years, female, white, stage:i, alive, 3136 days	2235.0
TCGA-KL-8335-01A	68 years, male, white, stage:iii, alive, 2815 days	2183.9
TCGA-KL-8338-01A	51 years, male, white, stage:iii, alive, 2633 days	2007.5
TCGA-KM-8442-01A	38 years, male, stage:ii, alive, 1437 days	1949.5
TCGA-KL-8342-01A	45 years, female, white, stage:ii, alive, 2248 days	1910.6
TCGA-KO-8417-01A	30 years, female, white, stage:i, alive, 2815 days	1892.0
TCGA-KN-8419-01A	43 years, male, black or african american, stage:ii, alive, 714 days	1807.1
TCGA-KO-8411-01A	58 years, male, white, stage:i, alive, 3958 days	1795.1
TCGA-KL-8336-01A	51 years, female, white, stage:iv, dead, 920 days	1744.9
TCGA-KN-8435-01A	59 years, male, white, stage:ii, alive, 3498 days	1703.0
TCGA-KN-8424-01A	42 years, female, white, stage:i, alive, 1983 days	1685.4
TCGA-KL-8341-01A	41 years, male, asian, stage:iv, dead, 754 days	1682.9
TCGA-KL-8324-01A	67 years, female, white, stage:ii, alive, 4676 days	1596.2
TCGA-KL-8346-01A	62 years, male, white, stage:ii, alive, 1897 days	1475.6
TCGA-KO-8416-01A	41 years, male, white, stage:iii, alive, 2752 days	1470.8
TCGA-KN-8429-01A	38 years, female, white, stage:iii, alive, 2650 days	1426.2
TCGA-KL-8337-01A	26 years, male, black or african american, stage:ii, alive, 1364 days	1421.2
TCGA-KO-8414-01A	50 years, female, white, stage:ii, alive, 3212 days	1304.5
TCGA-KN-8425-01A	53 years, male, white, stage:i, alive, 3179 days	1244.8
TCGA-KL-8344-01A	51 years, male, white, stage:iii, alive, 876 days	1093.1
TCGA-KL-8325-01A	56 years, female, white, stage:ii, dead, 725 days	985.0
TCGA-KN-8426-01A	50 years, male, white, stage:iv, alive, 108 days	922.9
TCGA-KL-8327-01A	46 years, female, white, stage:i, alive, 4169 days	758.6
TCGA-KN-8433-01A	46 years, female, white, stage:iii, alive, 341 days	753.9
TCGA-KO-8413-01A	46 years, male, white, stage:i, alive, 3038 days	657.4
TCGA-KN-8432-01A	86 years, female, white, stage:ii, alive, 76 days	576.6
TCGA-KN-8423-01A	44 years, male, white, stage:i, alive, 788 days	429.5
TCGA-KN-8436-01A	63 years, male, white, stage:ii, alive, 1288 days	168.6
TCGA-KN-8421-01A	48 years, female, white, stage:ii, alive, 2674 days	43.2
TCGA-KN-8427-01A	54 years, male, white, stage:iv, alive, 30 days	7.7
TCGA-KO-8404-01A	78 years, male, white, stage:iv, dead, 325 days	4.0
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