Expression of CLDN7 in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 91.41
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

126.7

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	271.5
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	260.8
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	245.1
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	231.1
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	222.4
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	219.5
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	217.2
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	212.4
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	211.2
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	204.0
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	200.9
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	200.7
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	196.5
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	193.4
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	192.7
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	192.7
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	192.5
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	186.9
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	184.5
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	182.7
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	179.3
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	178.6
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	176.7
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	175.3
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	173.1
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	172.2
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	170.1
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	169.3
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	168.5
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	168.2
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	167.7
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	166.7
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	164.6
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	164.0
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	163.4
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	163.0
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	162.8
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	161.2
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	158.4
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	158.0
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	157.3
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	157.3
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	155.1
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	154.5
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	153.6
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	153.5
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	152.0
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	152.0
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	150.0
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	149.7
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	148.2
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	146.8
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	145.9
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	145.4
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	145.2
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	144.1
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	143.5
TCGA-CL-4957-01A	79 years, female, dead, 425 days	140.2
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	139.8
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	139.8
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	139.1
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	135.1
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	134.4
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	132.7
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	132.1
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	131.9
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	130.8
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	129.4
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	128.0
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	126.9
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	126.4
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	126.3
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	126.1
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	125.0
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	123.2
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	123.1
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	122.4
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	120.8
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	120.6
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	120.4
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	119.0
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	118.9
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	118.5
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	115.2
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	115.2
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	115.1
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	113.9
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	113.5
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	111.0
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	110.8
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	110.2
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	110.1
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	109.7
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	109.5
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	108.2
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	107.8
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	106.9
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	106.7
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	106.3
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	106.2
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	105.7
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	105.3
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	105.1
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	103.2
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	103.2
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	103.0
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	103.0
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	102.7
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	102.6
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	101.7
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	101.0
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	99.7
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	98.7
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	97.7
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	97.4
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	97.4
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	97.0
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	96.0
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	95.6
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	91.4
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	91.4
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	90.4
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	89.8
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	89.1
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	85.2
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	83.3
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	79.6
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	79.2
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	78.5
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	78.5
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	78.3
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	78.1
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	78.1
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	77.4
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	76.5
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	76.5
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	76.3
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	75.8
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	74.4
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	72.5
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	72.1
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	72.0
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	70.4
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	69.8
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	69.0
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	68.1
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	67.5
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	65.9
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	63.6
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	62.7
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	61.3
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	60.2
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	59.3
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	57.9
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	57.8
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	57.1
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	56.4
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	54.6
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	51.5
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