Tissue expression of TUBB4B - Primary data - The Human Protein Atlas

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TUBB4B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

ANTIBODY PRIMARY DATAⁱ

Antibodies in assayⁱ

HPA043640 , HPA046280 , CAB010880

Tissue presentation order

Organ

Cell type

Alphabetical

Tissue			Antibody stainingⁱ This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation. Read more			Annotated protein expressionⁱ This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation. Read more
			HPA043640	HPA046280	CAB010880
			h m l n	h m l n	h m l n	h m l n
Brain
	Cerebral cortex	Neuronal cells
	Cerebral cortex	Endothelial cells
	Cerebral cortex	Glial cells
	Cerebral cortex	Neuropil
	Hippocampus	Neuronal cells
	Hippocampus	Glial cells
	Caudate	Neuronal cells
	Caudate	Glial cells
	Cerebellum	Purkinje cells
	Cerebellum	Cells in granular layer
	Cerebellum	Cells in molecular layer
Endocrine tissues
	Thyroid gland	Glandular cells
	Parathyroid gland	Glandular cells
	Adrenal gland	Glandular cells
Respiratory system
	Nasopharynx	Respiratory epithelial cells
	Bronchus	Respiratory epithelial cells			N/A
	Lung	Alveolar cells
	Lung	Macrophages
Proximal digestive tract
	Oral mucosa	Squamous epithelial cells
	Salivary gland	Glandular cells
	Esophagus	Squamous epithelial cells
Gastrointestinal tract
	Stomach 1	Glandular cells
	Stomach 2	Glandular cells
	Duodenum	Glandular cells
	Small intestine	Glandular cells
	Colon	Endothelial cells
	Colon	Glandular cells
	Colon	Peripheral nerve/ganglion
	Rectum	Glandular cells
Liver & gallbladder
	Liver	Hepatocytes
	Liver	Cholangiocytes
	Gallbladder	Glandular cells			N/A
Pancreas
	Pancreas	Exocrine glandular cells
	Pancreas	Pancreatic endocrine cells
Kidney & urinary bladder
	Kidney	Cells in glomeruli
	Kidney	Cells in tubules
	Urinary bladder	Urothelial cells
Male reproductive system
	Testis	Cells in seminiferous ducts		N/A	N/A
	Testis	Elongated or late spermatids	N/A
	Testis	Leydig cells
	Testis	Pachytene spermatocytes	N/A
	Testis	Peritubular cells	N/A
	Testis	Preleptotene spermatocytes	N/A
	Testis	Round or early spermatids	N/A
	Testis	Sertoli cells	N/A
	Testis	Spermatogonia cells	N/A
	Epididymis	Glandular cells
	Prostate	Glandular cells
	Seminal vesicle	Glandular cells
Breast and female reproductive system
	Breast	Adipocytes
	Breast	Glandular cells
	Breast	Myoepithelial cells
	Vagina	Squamous epithelial cells
	Cervix, uterine	Squamous epithelial cells	N/A
	Cervix, uterine	Glandular cells
	Endometrium 1	Glandular cells
	Endometrium 1	Cells in endometrial stroma
	Endometrium 2	Glandular cells
	Endometrium 2	Cells in endometrial stroma
	Fallopian tube	Glandular cells
	Ovary	Follicle cells	N/A	N/A	N/A
	Ovary	Ovarian stroma cells
	Placenta	Trophoblastic cells
	Placenta	Decidual cells	N/A
Muscle tissues
	Heart muscle	Cardiomyocytes
	Skeletal muscle	Myocytes
	Smooth muscle	Smooth muscle cells
Adipose & soft tissue
	Adipose tissue	Adipocytes
	Soft tissue 1	Peripheral nerve	N/A		N/A
	Soft tissue 1	Chondrocytes	N/A		N/A
	Soft tissue 1	Fibroblasts
	Soft tissue 2	Fibroblasts
	Soft tissue 2	Chondrocytes			N/A
	Soft tissue 2	Peripheral nerve	N/A	N/A
Skin
	Skin 1	Fibroblasts
	Skin 1	Keratinocytes
	Skin 1	Langerhans
	Skin 1	Melanocytes
	Skin 2	Epidermal cells
Bone marrow & lymphoid tissues
	Appendix	Glandular cells
	Appendix	Lymphoid tissue
	Bone marrow	Hematopoietic cells
	Lymph node	Germinal center cells
	Lymph node	Non-germinal center cells
	Tonsil	Germinal center cells
	Tonsil	Non-germinal center cells
	Tonsil	Squamous epithelial cells
	Spleen	Cells in white pulp
	Spleen	Cells in red pulp

Staining summaryⁱ

HPA043640	Ciliated cells in respiratory epithelium and fallopian tubes showed moderate cytoplasmic positivity. Epididymis and parts of gastrointestinal tract, neuropil, neuronal cells in hippocampus and cells in seminiferous ducts showed weak to moderate staining. Other normal tissues were mainly negative.
HPA046280	Moderate cytoplasmic positivity was observed in most normal tissues. Respiratory epithelia and fallopian tube showed strong cytoplasmic and membranous staining. Strong cytoplasmic positivity was exhibited in germinal center cells, cells in seminiferous ducts of testis, epididymis and peripheral nerve. Hepatocytes, glial cells, placenta and muscle tissues were negative.
CAB010880	A majority of normal cells displayed moderate to strong cytoplasmic staining combined with additional membranous positivity in a few cases. Peripheral nerves and cilia of fallopian tube, endometrium and nasopharynx displayed distinct positivity. Cells of kidney, liver, muscles, and endometrial stroma were negative.

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.