Brain tissue expression of EIF1AY - Summary

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Human gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF1AY
Human gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 1A, Y-linked
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Mouse gene	No orthologous mouse gene.
Pig gene	No orthologous pig gene.
Antibodies in assayⁱ The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.	HPA002561

HUMAN PROTEIN ATLAS INFORMATION
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. The Tissue classification is based on 37 human tissue types, where brain is represented by the highest expression value among the human brain regions (including spinal cord and corpus callosum that is excluded from the regional classification based on 10 main brain regions). The combination of tissue and regional classification can be found here Read more	Tissue enhanced (heart muscle, skeletal muscle)
	Human brain
Regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Regional distributionⁱ The regional distribution category is based on mRNA expression detected above cut off or not in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression is based on a combination of data from GTEX and FANTOM5. The distribution categories include: detected in all, detected in many, detected in some, detected in single and not detected. The classification rules are the same used for the tissue distribution category. Read more	Detected in many
Cellular locationⁱ Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain. Read more	Soma, nucleus and dendrite in neurons. Choroid plexus, ventricle wall and circumventricular organs of ependymal cells.
Protein profileⁱ A summary of the overall protein localization across the analyzed brain tissue. The summary is based on manual annotation. Mouse brain profiles includes a more extensive summary of the protein location while summaries with only human protein profile are more limited and are based on imported data/images from the Tissue Atlas stainings that has undergone an additional brain-centric curation step. Read more	Cytoplasmic and nucelar staining noted in virtually all neurons of the brain but with various intensities. Neocortex, pirifom cortex, hypothalamic PVN and periventricular nucleus, nucleus accumbens and various medullar/pontine nuclei exhibit especially strong immunoreactivity. Occasioanlly dendritic staining is noted. Plexus choroideus cells are also stained.

BRAIN RNA EXPRESSION

HUMAN

Expression

Detection

All organs

Consensus Human brain datasetⁱ

GTEx Human brain RNA-Seq datasetⁱ

FANTOM5 Human brain CAGE datasetⁱ

HPA Prefrontal cortex datasetⁱ

HUMAN BRAIN PROTEIN LOCATIONⁱ

Non curated brain data available in the Tissue Atlas.

MOUSE BRAIN PROTEIN LOCATIONⁱ

Protein profile	Cytoplasmic and nucelar staining noted in virtually all neurons of the brain but with various intensities. Neocortex, pirifom cortex, hypothalamic PVN and periventricular nucleus, nucleus accumbens and various medullar/pontine nuclei exhibit especially strong immunoreactivity. Occasioanlly dendritic staining is noted. Plexus choroideus cells are also stained.
Cellular location	Soma, nucleus and dendrite in neurons. Choroid plexus, ventricle wall and circumventricular organs of ependymal cells.
Protein profile reliability	Supported based on HPA002561

HPA Mouse staining intesityⁱ


Selected annotations	Olfactory bulb	Cerebral cortex	Midbrain	Pons
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