Expression of HLA-DRA in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 96.4
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

287.1

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	2852.8
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	1414.8
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	1338.2
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	1296.2
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	1136.6
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	1120.8
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	1109.5
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	709.6
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	688.4
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	673.5
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	656.2
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	579.6
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	562.2
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	557.5
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	547.6
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	546.6
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	540.8
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	525.7
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	523.3
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	498.6
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	492.4
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	478.0
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	465.0
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	464.9
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	460.0
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	455.6
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	452.4
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	444.4
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	438.2
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	429.0
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	427.8
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	422.6
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	419.9
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	407.0
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	403.1
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	393.2
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	374.7
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	369.6
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	368.8
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	367.8
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	356.9
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	350.5
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	347.7
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	333.4
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	332.1
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	323.8
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	323.0
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	304.9
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	303.9
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	299.1
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	297.8
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	278.9
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	276.9
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	276.1
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	273.4
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	265.8
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	265.5
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	259.8
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	256.0
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	253.8
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	251.3
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	251.2
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	250.7
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	248.3
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	247.5
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	246.9
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	245.1
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	243.0
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	234.7
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	234.3
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	230.3
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	227.2
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	221.4
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	218.2
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	215.1
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	212.0
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	204.0
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	202.0
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	201.1
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	199.4
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	195.3
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	194.8
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	194.6
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	193.0
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	192.7
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	190.6
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	187.2
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	185.7
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	185.7
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	182.4
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	176.8
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	176.1
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	171.9
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	169.6
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	169.5
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	169.0
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	168.2
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	164.4
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	156.8
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	156.3
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	156.3
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	153.9
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	148.8
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	145.1
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	145.1
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	141.0
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	140.8
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	135.2
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	131.9
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	131.0
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	128.9
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	128.8
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	124.0
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	121.1
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	121.0
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	118.2
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	111.8
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	110.5
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	105.7
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	104.7
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	100.6
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	99.2
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	93.6
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	92.2
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	90.0
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	89.3
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	86.6
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	85.4
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	84.6
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	82.1
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	79.9
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	79.6
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	77.7
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	74.9
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	74.6
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	74.0
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	71.8
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	71.2
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	68.8
TCGA-CL-4957-01A	79 years, female, dead, 425 days	67.9
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	64.4
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	61.6
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	60.0
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	57.7
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	54.5
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	52.1
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	50.2
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	49.3
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	48.9
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	48.1
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	44.4
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	44.3
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	41.7
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	41.2
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	39.6
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	27.3
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	26.7
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	21.8
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	21.7
Show allShow less