Expression of S1PR3 in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 1.28
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1.4

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	5.9
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	5.1
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	5.1
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	5.0
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	4.7
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	4.3
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	4.2
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	4.2
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	4.1
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	3.9
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	3.3
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	3.2
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	3.2
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	3.1
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	2.8
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	2.8
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	2.8
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	2.8
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	2.6
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	2.5
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	2.4
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	2.4
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	2.4
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	2.3
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	2.3
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	2.3
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	2.3
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	2.2
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	2.2
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	2.2
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	2.2
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	2.1
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	2.1
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	2.1
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	2.0
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	1.9
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	1.9
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	1.9
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	1.8
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	1.8
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	1.7
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	1.6
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	1.6
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	1.6
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	1.6
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	1.5
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	1.5
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	1.5
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	1.5
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	1.5
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	1.5
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	1.5
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	1.5
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	1.4
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	1.4
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	1.4
TCGA-CL-4957-01A	79 years, female, dead, 425 days	1.4
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	1.3
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	1.3
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	1.3
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	1.3
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	1.3
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	1.3
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	1.3
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	1.3
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	1.3
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	1.3
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	1.2
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	1.2
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	1.2
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	1.2
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	1.2
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	1.2
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	1.2
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	1.2
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	1.2
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	1.2
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	1.2
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	1.2
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	1.2
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	1.1
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	1.1
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	1.1
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	1.1
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	1.1
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	1.1
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	1.1
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	1.1
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	1.0
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	1.0
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	1.0
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	1.0
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	1.0
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	1.0
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	1.0
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	1.0
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	1.0
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	0.9
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	0.9
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	0.9
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	0.9
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	0.9
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	0.9
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	0.8
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	0.8
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	0.8
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	0.8
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	0.8
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	0.8
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	0.8
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	0.8
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	0.8
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	0.8
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	0.8
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	0.8
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	0.7
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	0.7
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	0.7
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	0.7
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	0.7
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	0.6
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	0.6
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	0.6
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	0.6
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	0.6
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	0.6
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	0.6
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	0.6
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	0.6
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	0.6
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	0.6
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	0.6
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	0.6
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	0.5
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	0.5
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	0.5
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	0.5
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	0.5
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	0.4
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	0.4
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	0.4
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	0.4
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	0.4
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	0.4
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	0.4
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	0.4
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	0.4
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	0.4
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	0.4
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	0.3
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	0.3
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	0.3
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	0.3
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	0.3
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	0.3
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	0.3
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	0.3
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	0.2
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	0.2
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