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PANCREATIC CANCER - Interactive survival scatter ploti
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
: Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A 5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A 5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
2284.7
Number of samples
176
Samples
Sample
Description
FPKM
TCGA-LB-A7SX-01A
74 years, female, black or african american, stage:iib, dead, 393 days
6984.5
TCGA-FB-AAQ1-01A
49 years, male, white, stage:iib, dead, 123 days
6468.8
TCGA-RB-A7B8-01A
81 years, female, white, stage:iib, dead, 466 days
6143.5
TCGA-2J-AABK-01A
71 years, male, white, stage:iib, alive, 484 days
6031.2
TCGA-Q3-AA2A-01A
64 years, female, white, stage:ib, alive, 95 days
5461.7
TCGA-F2-A8YN-01A
76 years, male, white, stage:iia, alive, 517 days
5368.9
TCGA-H8-A6C1-01A
53 years, male, white, stage:iia, alive, 671 days
5282.1
TCGA-HZ-A8P1-01A
81 years, male, white, stage:ib, alive, 7 days
5074.0
TCGA-2L-AAQJ-01A
49 years, female, white, stage:iii, dead, 394 days
4897.3
TCGA-HZ-8315-01A
54 years, female, white, stage:iia, dead, 299 days
4877.9
TCGA-3A-A9IL-01A
39 years, female, white, stage:i, alive, 2741 days
4488.9
TCGA-2L-AAQM-01A
52 years, male, white, stage:iib, alive, 1383 days
4483.4
TCGA-FB-AAPQ-01A
65 years, male, white, stage:iib, dead, 1130 days
4442.0
TCGA-HZ-A9TJ-01A
70 years, male, white, stage:iv, alive, 603 days
4432.8
TCGA-FB-AAPY-01A
71 years, male, white, stage:iib, dead, 1059 days
4219.1
TCGA-IB-7649-01A
73 years, female, stage:iib, dead, 467 days
4165.6
TCGA-HV-AA8V-01A
50 years, male, asian, stage:iib, alive, 920 days
4071.2
TCGA-3A-A9IN-01A
62 years, female, white, stage:ib, alive, 2084 days
4048.7
TCGA-FB-AAQ6-01A
85 years, male, white, stage:ia, dead, 244 days
3889.2
TCGA-IB-A5SP-01A
77 years, male, white, stage:iia, alive, 482 days
3859.6
TCGA-2J-AABH-01A
61 years, male, white, stage:iia, alive, 1287 days
3745.2
TCGA-HZ-8519-01A
73 years, male, white, stage:ia, alive, 454 days
3660.1
TCGA-FB-AAQ3-01A
65 years, female, white, stage:iib, dead, 31 days
3659.6
TCGA-US-A77E-01A
73 years, male, white, stage:iib, dead, 430 days
3648.0
TCGA-HZ-8638-01A
84 years, female, white, stage:ia, dead, 151 days
3584.4
TCGA-HZ-8317-01A
69 years, female, white, stage:iib, dead, 378 days
3483.7
TCGA-3A-A9I9-01A
67 years, male, white, stage:iia, dead, 634 days
3474.2
TCGA-HZ-A77P-01A
77 years, male, white, stage:iib, alive, 330 days
3417.4
TCGA-3E-AAAZ-01A
71 years, male, white, stage:iia, dead, 2182 days
3368.1
TCGA-HZ-8637-01A
76 years, female, white, stage:iib, dead, 517 days
3360.9
TCGA-3A-A9I7-01A
45 years, male, black or african american, stage:iib, alive, 1323 days
3292.2
TCGA-XD-AAUI-01A
50 years, female, white, stage:iib, dead, 366 days
3253.8
TCGA-Q3-A5QY-01A
58 years, male, white, stage:iib, alive, 416 days
3242.0
TCGA-3A-A9IV-01A
59 years, female, white, stage:ib, alive, 1103 days
3132.2
TCGA-2J-AABE-01A
73 years, male, white, stage:iia, alive, 676 days
3064.7
TCGA-3A-A9IS-01A
67 years, male, white, stage:ib, alive, 998 days
3057.3
TCGA-US-A779-01A
54 years, female, white, stage:iib, dead, 511 days
3047.0
TCGA-HV-AA8X-01A
75 years, female, asian, stage:iib, dead, 532 days
3046.4
TCGA-FB-AAPU-01A
41 years, female, asian, stage:iia, dead, 381 days
3040.6
TCGA-2L-AAQI-01A
66 years, male, white, stage:iib, dead, 103 days
3007.1
TCGA-2J-AABF-01A
73 years, male, white, stage:iib, dead, 691 days
3002.1
TCGA-IB-7645-01A
44 years, female, stage:iib, dead, 1502 days
3000.0
TCGA-XN-A8T5-01A
53 years, female, white, stage:ib, alive, 720 days
2995.1
TCGA-IB-AAUO-01A
64 years, female, white, stage:iib, dead, 239 days
2974.4
TCGA-FB-AAQ0-01A
68 years, male, white, stage:iia, dead, 473 days
2960.2
TCGA-FB-AAQ2-01A
81 years, female, white, stage:iib, dead, 153 days
2944.8
TCGA-2J-AAB8-01A
71 years, male, white, stage:iib, alive, 80 days
2932.2
TCGA-US-A776-01A
61 years, male, white, stage:iia, alive, 1216 days
2895.3
TCGA-2J-AABT-01A
72 years, female, white, stage:iib, alive, 319 days
2831.4
TCGA-IB-AAUQ-01A
50 years, male, white, stage:iib, dead, 183 days
2828.0
TCGA-FB-AAPP-01A
71 years, male, white, stage:iib, dead, 485 days
2821.0
TCGA-S4-A8RM-01A
67 years, male, white, stage:iib, alive, 737 days
2784.4
TCGA-3E-AAAY-01A
67 years, male, white, stage:iib, alive, 2285 days
2783.4
TCGA-3A-A9IH-01A
66 years, female, white, stage:ia, alive, 1021 days
2753.8
TCGA-2J-AABA-01A
55 years, male, white, stage:iib, dead, 607 days
2735.4
TCGA-FB-AAPS-01A
62 years, female, white, stage:iib, alive, 228 days
2697.3
TCGA-FB-AAPZ-01A
54 years, male, white, stage:iib, alive, 716 days
2657.3
TCGA-FB-A7DR-01A
48 years, male, asian, stage:iia, dead, 353 days
2656.7
TCGA-IB-A6UG-01A
65 years, male, white, stage:iib, dead, 41 days
2580.6
TCGA-US-A77G-01A
64 years, male, white, stage:iib, dead, 12 days
2571.3
TCGA-2J-AABR-01A
60 years, female, white, stage:iia, alive, 438 days
2541.2
TCGA-YH-A8SY-01A
73 years, female, white, alive, 388 days
2480.8
TCGA-3A-A9IX-01A
40 years, male, white, stage:ia, alive, 1037 days
2473.2
TCGA-2J-AAB4-01A
48 years, male, white, stage:iib, alive, 729 days
2471.6
TCGA-IB-AAUN-01A
74 years, female, white, stage:ib, dead, 144 days
2398.5
TCGA-IB-AAUW-01A
63 years, female, white, stage:iib, dead, 230 days
2391.1
TCGA-IB-A5SO-01A
71 years, male, white, stage:iib, dead, 365 days
2342.0
TCGA-L1-A7W4-01A
48 years, female, white, stage:iib, dead, 278 days
2336.5
TCGA-2J-AAB1-01A
65 years, male, white, stage:iib, dead, 66 days
2313.4
TCGA-2J-AABU-01A
56 years, male, white, stage:iib, dead, 277 days
2295.8
TCGA-3A-A9J0-01A
75 years, male, white, stage:iib, alive, 743 days
2292.7
TCGA-IB-7897-01A
54 years, female, white, stage:iib, dead, 486 days
2282.6
TCGA-IB-8126-01A
80 years, female, white, stage:iii, alive, 462 days
2277.2
TCGA-XD-AAUG-01A
66 years, female, white, stage:iv, alive, 420 days
2252.8
TCGA-3A-A9IR-01A
64 years, female, white, stage:ib, alive, 1542 days
2251.8
TCGA-S4-A8RP-01A
77 years, female, white, stage:iib, dead, 702 days
2247.3
TCGA-HZ-7289-01A
77 years, male, white, stage:iib, dead, 661 days
2241.7
TCGA-IB-A6UF-01A
63 years, male, white, stage:iib, alive, 666 days
2208.6
TCGA-2L-AAQE-01A
56 years, male, white, stage:iib, dead, 684 days
2207.5
TCGA-2J-AABO-01A
43 years, male, white, stage:iib, alive, 440 days
2177.9
TCGA-HZ-A77Q-01A
55 years, female, white, stage:iib, alive, 33 days
2176.5
TCGA-HV-A5A5-01A
61 years, female, asian, stage:iib, alive, 289 days
2162.1
TCGA-FB-A78T-01A
71 years, female, white, stage:iib, dead, 375 days
2156.5
TCGA-F2-6880-01A
70 years, male, white, stage:iib, alive, 289 days
2155.3
TCGA-IB-AAUT-01A
65 years, male, white, stage:iib, alive, 287 days
2116.0
TCGA-3A-A9IB-01A
69 years, female, white, stage:iib, dead, 224 days
2107.6
TCGA-IB-AAUM-01A
76 years, male, white, stage:iib, alive, 8 days
2064.4
TCGA-IB-AAUR-01A
67 years, male, white, stage:iib, alive, 338 days
2061.7
TCGA-RB-AA9M-01A
43 years, male, white, stage:iib, alive, 286 days
2027.3
TCGA-XD-AAUH-01A
57 years, female, white, stage:iib, alive, 395 days
2006.0
TCGA-S4-A8RO-01A
75 years, female, white, stage:iib, alive, 525 days
1996.3
TCGA-IB-AAUP-01A
68 years, male, white, stage:iib, alive, 431 days
1989.0
TCGA-2L-AAQA-01A
76 years, male, white, stage:iib, dead, 143 days
1979.5
TCGA-HZ-7926-01A
57 years, male, black or african american, stage:iib, dead, 518 days
1968.7
TCGA-3A-A9IU-01A
65 years, male, white, stage:iib, dead, 458 days
1941.0
TCGA-IB-AAUU-01A
35 years, male, white, stage:iib, alive, 245 days
1920.7
TCGA-2J-AABI-01A
55 years, female, white, stage:iia, alive, 969 days
1918.3
TCGA-IB-AAUS-01A
84 years, female, white, stage:iib, alive, 225 days
1914.8
TCGA-IB-AAUV-01A
49 years, male, white, stage:iib, alive, 404 days
1900.6
TCGA-IB-A7LX-01A
57 years, male, white, stage:iib, dead, 250 days
1844.2
TCGA-XN-A8T3-01A
67 years, male, white, stage:ib, alive, 951 days
1843.9
TCGA-F2-A7TX-01A
77 years, male, white, stage:iib, dead, 95 days
1825.9
TCGA-IB-A7M4-01A
81 years, male, white, stage:iib, alive, 483 days
1823.7
TCGA-IB-7644-01A
65 years, female, white, stage:iv, dead, 394 days
1822.6
TCGA-HZ-7924-01A
60 years, female, white, stage:iia, alive, 840 days
1814.8
TCGA-PZ-A5RE-01A
44 years, female, white, stage:iib, dead, 470 days
1804.4
TCGA-YB-A89D-01A
59 years, male, white, stage:iib, alive, 350 days
1803.2
TCGA-IB-7652-01A
49 years, female, asian, stage:iib, alive, 1116 days
1801.6
TCGA-3A-A9IO-01A
56 years, male, white, alive, 1942 days
1797.9
TCGA-US-A774-01A
76 years, female, white, stage:iib, dead, 695 days
1793.0
TCGA-Z5-AAPL-01A
74 years, female, white, stage:iia, alive, 467 days
1737.9
TCGA-HZ-A4BK-01A
72 years, male, white, stage:iib, alive, 657 days
1709.6
TCGA-IB-7646-01A
60 years, male, white, stage:iib, dead, 145 days
1666.1
TCGA-HZ-7923-01A
65 years, male, white, stage:iia, alive, 314 days
1665.3
TCGA-RL-AAAS-01A
60 years, female, white, stage:ib, alive, 9 days
1630.4
TCGA-IB-7887-01A
62 years, female, white, stage:iib, dead, 110 days
1629.8
TCGA-F2-A44H-01A
65 years, male, white, stage:iia, alive, 586 days
1573.9
TCGA-IB-A5ST-01A
64 years, female, white, stage:iib, alive, 635 days
1546.5
TCGA-HZ-8636-01A
58 years, female, white, stage:iv, dead, 545 days
1528.9
TCGA-M8-A5N4-01A
48 years, female, stage:iia, alive, 584 days
1525.8
TCGA-HZ-8002-01A
61 years, male, white, stage:iib, dead, 366 days
1521.2
TCGA-IB-A5SQ-01A
56 years, female, white, stage:ib, dead, 219 days
1515.6
TCGA-IB-7651-01A
64 years, female, white, stage:iib, dead, 603 days
1513.4
TCGA-LB-A9Q5-01A
63 years, female, white, stage:iib, dead, 313 days
1509.4
TCGA-3A-A9IC-01A
61 years, female, white, stage:iib, dead, 738 days
1496.5
TCGA-IB-7885-01A
78 years, female, white, stage:iib, alive, 1257 days
1471.9
TCGA-HZ-A77O-01A
77 years, female, white, stage:iib, dead, 160 days
1466.3
TCGA-2J-AAB9-01A
71 years, female, white, stage:iib, dead, 627 days
1435.3
TCGA-3A-A9I5-01A
58 years, male, white, alive, 1794 days
1421.9
TCGA-IB-8127-01A
59 years, male, white, stage:iib, alive, 522 days
1419.7
TCGA-HV-A5A3-01A
50 years, male, asian, stage:iia, dead, 128 days
1404.6
TCGA-IB-7890-01A
73 years, male, stage:ib, dead, 598 days
1377.3
TCGA-YY-A8LH-01A
61 years, female, white, stage:iib, alive, 2016 days
1362.9
TCGA-2L-AAQL-01A
82 years, male, white, stage:iib, dead, 292 days
1355.8
TCGA-HZ-8003-01A
65 years, female, white, stage:iib, dead, 596 days
1304.6
TCGA-HZ-7925-01A
66 years, male, white, stage:iib, dead, 614 days
1288.9
TCGA-OE-A75W-01A
75 years, male, white, stage:iia, dead, 267 days
1286.4
TCGA-3A-A9IZ-01A
47 years, male, white, stage:iib, dead, 308 days
1268.8
TCGA-IB-7888-01A
66 years, female, black or african american, stage:iia, dead, 1332 days
1266.8
TCGA-F2-7276-01A
64 years, male, white, stage:iib, dead, 216 days
1237.8
TCGA-HZ-7920-01A
71 years, male, white, stage:ib, dead, 236 days
1235.7
TCGA-IB-7654-01A
80 years, male, white, stage:iib, dead, 476 days
1208.9
TCGA-H6-8124-01A
56 years, female, white, stage:iib, alive, 392 days
1204.9
TCGA-HZ-7919-01A
52 years, female, white, stage:iib, dead, 593 days
1192.9
TCGA-XD-AAUL-01A
56 years, male, white, stage:iia, alive, 498 days
1140.5
TCGA-2J-AAB6-01A
75 years, male, white, stage:iia, dead, 293 days
1113.1
TCGA-IB-7891-01A
49 years, female, white, stage:iib, dead, 913 days
1092.0
TCGA-US-A77J-01A
81 years, female, white, stage:iib, dead, 568 days
1079.8
TCGA-HV-A5A6-01A
65 years, female, asian, stage:iib, dead, 2036 days
1070.5
TCGA-HV-A5A4-01A
72 years, female, asian, stage:iia, alive, 232 days
1031.1
TCGA-F2-A44G-01A
79 years, female, white, stage:iib, dead, 233 days
1007.3
TCGA-IB-7889-01A
86 years, female, white, stage:iib, dead, 481 days
975.1
TCGA-3A-A9IJ-01A
65 years, male, white, stage:ib, alive, 1854 days
966.4
TCGA-F2-7273-01A
54 years, male, black or african american, stage:iib, dead, 592 days
965.5
TCGA-IB-7893-01A
64 years, male, white, stage:iia, dead, 117 days
936.2
TCGA-F2-6879-01A
57 years, male, white, stage:iib, dead, 334 days
932.3
TCGA-HZ-A49G-01A
58 years, female, white, stage:iib, alive, 660 days
930.8
TCGA-H6-A45N-01A
88 years, female, white, stage:iib, dead, 421 days
929.8
TCGA-IB-A5SS-01A
64 years, female, white, stage:iib, dead, 460 days
914.6
TCGA-HZ-7918-01A
72 years, male, white, stage:iib, alive, 969 days
899.1
TCGA-2J-AABP-01A
58 years, female, white, stage:iib, alive, 463 days
862.0
TCGA-HZ-8001-01A
69 years, male, white, stage:iii, alive, 706 days
861.7
TCGA-HZ-7922-01A
61 years, female, white, stage:iib, alive, 4 days
826.4
TCGA-LB-A8F3-01A
64 years, female, black or african american, stage:iia, alive, 379 days
825.4
TCGA-FB-A4P5-01A
69 years, female, white, stage:iib, dead, 179 days
798.4
TCGA-FB-A4P6-01A
54 years, male, white, stage:iib, alive, 767 days
789.4
TCGA-HZ-A49H-01A
68 years, female, white, stage:iib, alive, 491 days
738.4
TCGA-HZ-A49I-01A
77 years, male, white, stage:iib, dead, 308 days
676.9
TCGA-HZ-8005-01A
81 years, male, white, stage:iib, dead, 120 days
645.5
TCGA-IB-7886-01A
80 years, male, white, stage:iib, dead, 123 days
634.4
TCGA-HZ-A4BH-01A
75 years, male, white, stage:iib, alive, 194 days
616.4
TCGA-HV-A7OL-01A
70 years, male, asian, stage:iia, alive, 252 days
574.0
TCGA-FB-A545-01A
72 years, female, white, stage:iib, dead, 732 days
510.2
TCGA-FB-A5VM-01A
74 years, male, white, stage:ib, dead, 498 days
461.4
TCGA-HV-A7OP-01A
72 years, male, asian, stage:iib, alive, 978 days
325.9
TCGA-2J-AABV-01A
74 years, male, white, stage:iib, dead, 652 days
307.3
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PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.