Expression of HLA-B in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 512.82
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

685.9

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	2454.6
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	1794.3
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	1719.2
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	1456.8
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	1403.3
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	1365.4
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	1359.0
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	1316.6
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	1248.0
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	1214.1
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	1200.0
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	1177.0
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	1160.5
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	1116.8
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	1108.3
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	1103.0
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	1081.8
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	1080.5
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	1068.1
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	1043.5
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	1030.2
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	1020.7
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	1017.3
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	1017.2
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	1013.2
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	988.6
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	987.5
TCGA-CL-4957-01A	79 years, female, dead, 425 days	981.6
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	970.3
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	959.5
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	951.1
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	950.6
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	936.0
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	931.8
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	925.3
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	922.9
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	914.0
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	911.6
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	903.7
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	895.8
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	895.4
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	891.5
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	870.7
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	863.2
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	859.0
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	858.5
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	851.3
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	842.3
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	840.8
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	834.8
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	831.7
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	824.1
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	821.8
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	819.2
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	815.6
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	794.2
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	793.7
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	787.7
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	767.7
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	762.5
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	760.8
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	757.8
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	751.7
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	747.4
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	737.5
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	725.7
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	721.4
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	718.3
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	707.9
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	704.0
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	683.1
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	680.5
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	680.1
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	675.5
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	669.5
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	669.4
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	667.1
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	655.5
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	653.0
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	645.8
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	640.3
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	640.0
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	635.8
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	629.5
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	625.6
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	625.1
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	622.9
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	609.3
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	591.9
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	575.8
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	574.2
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	574.2
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	566.7
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	563.3
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	560.1
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	551.9
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	530.1
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	527.4
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	524.6
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	515.0
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	513.1
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	512.9
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	512.7
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	509.5
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	508.8
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	504.2
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	501.0
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	499.3
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	499.2
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	495.2
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	494.5
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	484.9
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	484.3
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	473.8
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	469.0
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	465.8
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	461.0
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	451.8
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	442.5
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	439.0
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	437.8
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	433.0
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	428.2
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	423.8
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	422.4
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	408.4
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	408.3
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	406.9
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	402.1
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	394.1
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	379.3
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	379.0
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	376.6
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	375.1
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	357.5
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	353.3
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	330.4
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	312.8
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	310.1
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	299.6
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	289.3
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	274.2
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	273.5
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	268.0
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	241.9
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	236.0
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	233.7
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	221.1
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	209.5
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	192.7
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	176.8
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	168.5
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	161.0
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	158.7
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	149.8
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	122.8
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	115.8
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	107.4
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	85.5
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