Expression of INS in pancreatic cancer - The Human Protein Atlas

PANCREATIC CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

INS is not prognostic in pancreatic cancer

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 9.44
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1751.3

Number of samples

176

Samples

Sample	Description	FPKM
TCGA-3A-A9IN-01A	62 years, female, white, stage:ib, alive, 2084 days	29297.4
TCGA-XD-AAUH-01A	57 years, female, white, stage:iib, alive, 395 days	21777.9
TCGA-2J-AABK-01A	71 years, male, white, stage:iib, alive, 484 days	14849.0
TCGA-3A-A9I5-01A	58 years, male, white, alive, 1794 days	10864.9
TCGA-H6-A45N-01A	88 years, female, white, stage:iib, dead, 421 days	10771.4
TCGA-RB-AA9M-01A	43 years, male, white, stage:iib, alive, 286 days	9928.0
TCGA-HV-A5A5-01A	61 years, female, asian, stage:iib, alive, 289 days	9827.5
TCGA-FB-A4P5-01A	69 years, female, white, stage:iib, dead, 179 days	8520.4
TCGA-IB-A5SQ-01A	56 years, female, white, stage:ib, dead, 219 days	8490.3
TCGA-XD-AAUG-01A	66 years, female, white, stage:iv, alive, 420 days	8404.9
TCGA-HZ-7920-01A	71 years, male, white, stage:ib, dead, 236 days	7576.8
TCGA-HZ-8637-01A	76 years, female, white, stage:iib, dead, 517 days	7284.3
TCGA-US-A77J-01A	81 years, female, white, stage:iib, dead, 568 days	6760.5
TCGA-IB-7897-01A	54 years, female, white, stage:iib, dead, 486 days	6653.6
TCGA-FB-AAQ2-01A	81 years, female, white, stage:iib, dead, 153 days	5536.3
TCGA-US-A779-01A	54 years, female, white, stage:iib, dead, 511 days	5234.7
TCGA-FB-A5VM-01A	74 years, male, white, stage:ib, dead, 498 days	5220.2
TCGA-HZ-A4BH-01A	75 years, male, white, stage:iib, alive, 194 days	5098.3
TCGA-HZ-8001-01A	69 years, male, white, stage:iii, alive, 706 days	5096.8
TCGA-HZ-8519-01A	73 years, male, white, stage:ia, alive, 454 days	4992.9
TCGA-2J-AABF-01A	73 years, male, white, stage:iib, dead, 691 days	4917.0
TCGA-2L-AAQL-01A	82 years, male, white, stage:iib, dead, 292 days	4334.8
TCGA-HZ-7923-01A	65 years, male, white, stage:iia, alive, 314 days	4244.7
TCGA-2J-AABH-01A	61 years, male, white, stage:iia, alive, 1287 days	4018.9
TCGA-IB-AAUW-01A	63 years, female, white, stage:iib, dead, 230 days	3619.7
TCGA-2J-AAB4-01A	48 years, male, white, stage:iib, alive, 729 days	3254.3
TCGA-XN-A8T3-01A	67 years, male, white, stage:ib, alive, 951 days	3020.2
TCGA-IB-AAUQ-01A	50 years, male, white, stage:iib, dead, 183 days	2880.3
TCGA-2J-AABR-01A	60 years, female, white, stage:iia, alive, 438 days	2784.4
TCGA-HV-A5A4-01A	72 years, female, asian, stage:iia, alive, 232 days	2784.3
TCGA-F2-7276-01A	64 years, male, white, stage:iib, dead, 216 days	2744.8
TCGA-IB-A5SO-01A	71 years, male, white, stage:iib, dead, 365 days	2739.1
TCGA-HZ-A49G-01A	58 years, female, white, stage:iib, alive, 660 days	2463.9
TCGA-IB-A5SP-01A	77 years, male, white, stage:iia, alive, 482 days	2396.7
TCGA-YB-A89D-01A	59 years, male, white, stage:iib, alive, 350 days	2367.6
TCGA-F2-7273-01A	54 years, male, black or african american, stage:iib, dead, 592 days	2345.1
TCGA-S4-A8RP-01A	77 years, female, white, stage:iib, dead, 702 days	2330.7
TCGA-IB-7888-01A	66 years, female, black or african american, stage:iia, dead, 1332 days	2305.3
TCGA-2L-AAQI-01A	66 years, male, white, stage:iib, dead, 103 days	2288.1
TCGA-3A-A9IH-01A	66 years, female, white, stage:ia, alive, 1021 days	2151.7
TCGA-F2-6880-01A	70 years, male, white, stage:iib, alive, 289 days	2036.7
TCGA-2J-AABO-01A	43 years, male, white, stage:iib, alive, 440 days	1938.1
TCGA-2J-AAB6-01A	75 years, male, white, stage:iia, dead, 293 days	1834.8
TCGA-XD-AAUI-01A	50 years, female, white, stage:iib, dead, 366 days	1664.2
TCGA-FB-AAQ1-01A	49 years, male, white, stage:iib, dead, 123 days	1661.6
TCGA-S4-A8RO-01A	75 years, female, white, stage:iib, alive, 525 days	1655.8
TCGA-LB-A8F3-01A	64 years, female, black or african american, stage:iia, alive, 379 days	1526.7
TCGA-LB-A9Q5-01A	63 years, female, white, stage:iib, dead, 313 days	1501.1
TCGA-IB-7654-01A	80 years, male, white, stage:iib, dead, 476 days	1406.6
TCGA-IB-AAUU-01A	35 years, male, white, stage:iib, alive, 245 days	1393.9
TCGA-HZ-8003-01A	65 years, female, white, stage:iib, dead, 596 days	1381.9
TCGA-3A-A9I9-01A	67 years, male, white, stage:iia, dead, 634 days	1362.1
TCGA-FB-A4P6-01A	54 years, male, white, stage:iib, alive, 767 days	1358.6
TCGA-IB-7649-01A	73 years, female, stage:iib, dead, 467 days	1340.7
TCGA-FB-AAPU-01A	41 years, female, asian, stage:iia, dead, 381 days	1297.7
TCGA-HZ-A49H-01A	68 years, female, white, stage:iib, alive, 491 days	1229.4
TCGA-2J-AAB1-01A	65 years, male, white, stage:iib, dead, 66 days	1186.8
TCGA-3E-AAAY-01A	67 years, male, white, stage:iib, alive, 2285 days	1132.1
TCGA-IB-7891-01A	49 years, female, white, stage:iib, dead, 913 days	1118.1
TCGA-IB-7652-01A	49 years, female, asian, stage:iib, alive, 1116 days	1086.0
TCGA-US-A77G-01A	64 years, male, white, stage:iib, dead, 12 days	973.5
TCGA-IB-AAUV-01A	49 years, male, white, stage:iib, alive, 404 days	952.0
TCGA-2J-AAB9-01A	71 years, female, white, stage:iib, dead, 627 days	877.2
TCGA-IB-AAUM-01A	76 years, male, white, stage:iib, alive, 8 days	820.7
TCGA-3A-A9IO-01A	56 years, male, white, alive, 1942 days	754.0
TCGA-HZ-7918-01A	72 years, male, white, stage:iib, alive, 969 days	693.3
TCGA-FB-AAPZ-01A	54 years, male, white, stage:iib, alive, 716 days	691.9
TCGA-F2-A44H-01A	65 years, male, white, stage:iia, alive, 586 days	649.1
TCGA-OE-A75W-01A	75 years, male, white, stage:iia, dead, 267 days	621.5
TCGA-XN-A8T5-01A	53 years, female, white, stage:ib, alive, 720 days	612.6
TCGA-HZ-8002-01A	61 years, male, white, stage:iib, dead, 366 days	611.8
TCGA-RB-A7B8-01A	81 years, female, white, stage:iib, dead, 466 days	611.3
TCGA-HV-A7OL-01A	70 years, male, asian, stage:iia, alive, 252 days	607.8
TCGA-HZ-8636-01A	58 years, female, white, stage:iv, dead, 545 days	601.4
TCGA-RL-AAAS-01A	60 years, female, white, stage:ib, alive, 9 days	597.5
TCGA-XD-AAUL-01A	56 years, male, white, stage:iia, alive, 498 days	595.8
TCGA-FB-AAPQ-01A	65 years, male, white, stage:iib, dead, 1130 days	593.9
TCGA-FB-A78T-01A	71 years, female, white, stage:iib, dead, 375 days	580.4
TCGA-HV-AA8V-01A	50 years, male, asian, stage:iib, alive, 920 days	578.4
TCGA-IB-AAUN-01A	74 years, female, white, stage:ib, dead, 144 days	574.0
TCGA-FB-AAQ6-01A	85 years, male, white, stage:ia, dead, 244 days	573.5
TCGA-HZ-A77P-01A	77 years, male, white, stage:iib, alive, 330 days	571.1
TCGA-FB-AAPY-01A	71 years, male, white, stage:iib, dead, 1059 days	570.2
TCGA-FB-AAQ3-01A	65 years, female, white, stage:iib, dead, 31 days	538.6
TCGA-IB-8126-01A	80 years, female, white, stage:iii, alive, 462 days	533.8
TCGA-FB-AAPS-01A	62 years, female, white, stage:iib, alive, 228 days	533.4
TCGA-IB-7890-01A	73 years, male, stage:ib, dead, 598 days	525.4
TCGA-US-A77E-01A	73 years, male, white, stage:iib, dead, 430 days	493.8
TCGA-HV-AA8X-01A	75 years, female, asian, stage:iib, dead, 532 days	443.6
TCGA-LB-A7SX-01A	74 years, female, black or african american, stage:iib, dead, 393 days	406.4
TCGA-F2-A7TX-01A	77 years, male, white, stage:iib, dead, 95 days	379.9
TCGA-2J-AABE-01A	73 years, male, white, stage:iia, alive, 676 days	378.4
TCGA-IB-A7M4-01A	81 years, male, white, stage:iib, alive, 483 days	373.2
TCGA-HZ-7919-01A	52 years, female, white, stage:iib, dead, 593 days	366.9
TCGA-IB-AAUT-01A	65 years, male, white, stage:iib, alive, 287 days	340.8
TCGA-FB-A545-01A	72 years, female, white, stage:iib, dead, 732 days	333.6
TCGA-L1-A7W4-01A	48 years, female, white, stage:iib, dead, 278 days	304.3
TCGA-IB-7651-01A	64 years, female, white, stage:iib, dead, 603 days	297.5
TCGA-YY-A8LH-01A	61 years, female, white, stage:iib, alive, 2016 days	292.1
TCGA-HZ-A77O-01A	77 years, female, white, stage:iib, dead, 160 days	289.1
TCGA-HZ-A9TJ-01A	70 years, male, white, stage:iv, alive, 603 days	280.6
TCGA-H6-8124-01A	56 years, female, white, stage:iib, alive, 392 days	269.8
TCGA-2L-AAQE-01A	56 years, male, white, stage:iib, dead, 684 days	268.8
TCGA-HZ-A49I-01A	77 years, male, white, stage:iib, dead, 308 days	265.1
TCGA-IB-A6UF-01A	63 years, male, white, stage:iib, alive, 666 days	254.8
TCGA-S4-A8RM-01A	67 years, male, white, stage:iib, alive, 737 days	249.7
TCGA-US-A774-01A	76 years, female, white, stage:iib, dead, 695 days	239.7
TCGA-3A-A9IB-01A	69 years, female, white, stage:iib, dead, 224 days	223.2
TCGA-IB-8127-01A	59 years, male, white, stage:iib, alive, 522 days	219.5
TCGA-HZ-A8P1-01A	81 years, male, white, stage:ib, alive, 7 days	214.4
TCGA-IB-A6UG-01A	65 years, male, white, stage:iib, dead, 41 days	213.6
TCGA-2J-AABV-01A	74 years, male, white, stage:iib, dead, 652 days	209.1
TCGA-PZ-A5RE-01A	44 years, female, white, stage:iib, dead, 470 days	204.1
TCGA-IB-AAUO-01A	64 years, female, white, stage:iib, dead, 239 days	191.2
TCGA-HZ-7925-01A	66 years, male, white, stage:iib, dead, 614 days	137.5
TCGA-IB-7645-01A	44 years, female, stage:iib, dead, 1502 days	113.7
TCGA-HZ-7922-01A	61 years, female, white, stage:iib, alive, 4 days	105.0
TCGA-3A-A9IU-01A	65 years, male, white, stage:iib, dead, 458 days	90.6
TCGA-HZ-A4BK-01A	72 years, male, white, stage:iib, alive, 657 days	84.2
TCGA-IB-7893-01A	64 years, male, white, stage:iia, dead, 117 days	82.0
TCGA-F2-A8YN-01A	76 years, male, white, stage:iia, alive, 517 days	80.2
TCGA-2L-AAQA-01A	76 years, male, white, stage:iib, dead, 143 days	79.8
TCGA-IB-AAUP-01A	68 years, male, white, stage:iib, alive, 431 days	69.2
TCGA-YH-A8SY-01A	73 years, female, white, alive, 388 days	67.1
TCGA-IB-AAUS-01A	84 years, female, white, stage:iib, alive, 225 days	66.0
TCGA-IB-7889-01A	86 years, female, white, stage:iib, dead, 481 days	64.9
TCGA-3A-A9IZ-01A	47 years, male, white, stage:iib, dead, 308 days	40.3
TCGA-US-A776-01A	61 years, male, white, stage:iia, alive, 1216 days	38.5
TCGA-HZ-8315-01A	54 years, female, white, stage:iia, dead, 299 days	38.4
TCGA-F2-A44G-01A	79 years, female, white, stage:iib, dead, 233 days	35.5
TCGA-IB-7885-01A	78 years, female, white, stage:iib, alive, 1257 days	34.9
TCGA-HV-A5A3-01A	50 years, male, asian, stage:iia, dead, 128 days	28.1
TCGA-HZ-8317-01A	69 years, female, white, stage:iib, dead, 378 days	28.0
TCGA-3A-A9IJ-01A	65 years, male, white, stage:ib, alive, 1854 days	25.9
TCGA-2L-AAQJ-01A	49 years, female, white, stage:iii, dead, 394 days	24.0
TCGA-H8-A6C1-01A	53 years, male, white, stage:iia, alive, 671 days	19.9
TCGA-Q3-A5QY-01A	58 years, male, white, stage:iib, alive, 416 days	18.1
TCGA-HZ-7926-01A	57 years, male, black or african american, stage:iib, dead, 518 days	13.1
TCGA-IB-7646-01A	60 years, male, white, stage:iib, dead, 145 days	11.8
TCGA-IB-A7LX-01A	57 years, male, white, stage:iib, dead, 250 days	9.7
TCGA-IB-7886-01A	80 years, male, white, stage:iib, dead, 123 days	9.1
TCGA-3A-A9I7-01A	45 years, male, black or african american, stage:iib, alive, 1323 days	9.0
TCGA-3A-A9IC-01A	61 years, female, white, stage:iib, dead, 738 days	9.0
TCGA-FB-AAPP-01A	71 years, male, white, stage:iib, dead, 485 days	8.3
TCGA-3A-A9IX-01A	40 years, male, white, stage:ia, alive, 1037 days	7.9
TCGA-2J-AABI-01A	55 years, female, white, stage:iia, alive, 969 days	7.7
TCGA-HZ-8638-01A	84 years, female, white, stage:ia, dead, 151 days	7.2
TCGA-HZ-8005-01A	81 years, male, white, stage:iib, dead, 120 days	7.0
TCGA-2J-AABA-01A	55 years, male, white, stage:iib, dead, 607 days	3.8
TCGA-3E-AAAZ-01A	71 years, male, white, stage:iia, dead, 2182 days	3.6
TCGA-IB-A5SS-01A	64 years, female, white, stage:iib, dead, 460 days	3.6
TCGA-F2-6879-01A	57 years, male, white, stage:iib, dead, 334 days	2.6
TCGA-FB-AAQ0-01A	68 years, male, white, stage:iia, dead, 473 days	2.3
TCGA-HV-A5A6-01A	65 years, female, asian, stage:iib, dead, 2036 days	1.9
TCGA-IB-7887-01A	62 years, female, white, stage:iib, dead, 110 days	1.6
TCGA-2J-AABU-01A	56 years, male, white, stage:iib, dead, 277 days	1.5
TCGA-IB-A5ST-01A	64 years, female, white, stage:iib, alive, 635 days	1.4
TCGA-IB-7644-01A	65 years, female, white, stage:iv, dead, 394 days	1.3
TCGA-FB-A7DR-01A	48 years, male, asian, stage:iia, dead, 353 days	1.2
TCGA-3A-A9J0-01A	75 years, male, white, stage:iib, alive, 743 days	1.1
TCGA-3A-A9IS-01A	67 years, male, white, stage:ib, alive, 998 days	1.0
TCGA-IB-AAUR-01A	67 years, male, white, stage:iib, alive, 338 days	0.8
TCGA-3A-A9IL-01A	39 years, female, white, stage:i, alive, 2741 days	0.7
TCGA-3A-A9IV-01A	59 years, female, white, stage:ib, alive, 1103 days	0.1
TCGA-Z5-AAPL-01A	74 years, female, white, stage:iia, alive, 467 days	0.1
TCGA-2J-AABT-01A	72 years, female, white, stage:iib, alive, 319 days	0.1
TCGA-M8-A5N4-01A	48 years, female, stage:iia, alive, 584 days	0.1
TCGA-HV-A7OP-01A	72 years, male, asian, stage:iib, alive, 978 days	0.1
TCGA-2J-AAB8-01A	71 years, male, white, stage:iib, alive, 80 days	0.1
TCGA-HZ-7924-01A	60 years, female, white, stage:iia, alive, 840 days	0.0
TCGA-3A-A9IR-01A	64 years, female, white, stage:ib, alive, 1542 days	0.0
TCGA-2L-AAQM-01A	52 years, male, white, stage:iib, alive, 1383 days	0.0
TCGA-HZ-7289-01A	77 years, male, white, stage:iib, dead, 661 days	0.0
TCGA-Q3-AA2A-01A	64 years, female, white, stage:ib, alive, 95 days	0.0
TCGA-2J-AABP-01A	58 years, female, white, stage:iib, alive, 463 days	0.0
TCGA-HZ-A77Q-01A	55 years, female, white, stage:iib, alive, 33 days	0.0
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PANCREATIC CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA004932	Antibody CAB000048	Antibody CAB012098	Antibody CAB053843
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details