Expression of TXNIP in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 170.04
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

120.6

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	477.7
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	458.9
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	387.8
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	353.0
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	314.1
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	307.5
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	303.2
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	291.1
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	280.4
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	279.7
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	271.4
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	253.7
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	243.8
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	242.3
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	241.0
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	240.5
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	232.1
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	227.1
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	220.9
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	214.9
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	204.9
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	202.3
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	201.2
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	197.9
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	196.6
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	196.2
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	191.3
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	183.2
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	182.3
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	180.0
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	179.9
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	179.4
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	160.6
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	160.1
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	158.7
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	157.8
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	154.2
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	153.9
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	153.6
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	153.4
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	153.2
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	149.2
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	148.4
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	147.8
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	144.3
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	143.7
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	142.6
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	140.7
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	140.4
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	140.2
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	137.0
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	136.0
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	132.5
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	128.3
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	128.0
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	123.9
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	122.8
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	122.7
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	121.5
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	121.3
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	121.3
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	120.4
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	120.3
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	118.2
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	116.0
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	114.8
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	114.5
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	113.6
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	113.3
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	112.7
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	112.4
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	110.3
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	107.7
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	104.9
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	103.8
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	102.5
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	102.3
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	101.9
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	101.2
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	101.0
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	100.2
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	99.0
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	98.9
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	98.0
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	96.2
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	95.0
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	94.8
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	94.6
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	94.5
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	94.2
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	93.4
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	91.1
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	91.1
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	90.5
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	90.4
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	90.1
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	89.5
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	88.8
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	88.1
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	87.6
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	87.4
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	83.8
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	83.6
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	83.4
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	81.1
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	78.1
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	78.0
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	77.8
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	72.8
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	72.5
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	69.6
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	69.3
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	68.8
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	68.5
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	67.7
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	64.5
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	64.4
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	64.4
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	64.3
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	63.7
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	63.1
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	61.0
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	60.8
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	59.0
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	58.8
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	57.9
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	57.5
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	56.0
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	51.6
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	50.6
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	48.9
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	48.8
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	48.8
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	46.3
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	46.0
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	44.9
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	42.7
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	42.3
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	41.6
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	39.4
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	39.3
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	38.6
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	38.4
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	38.3
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	37.7
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	35.6
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	34.9
TCGA-CL-4957-01A	79 years, female, dead, 425 days	32.9
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	31.0
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	27.8
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	27.7
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	26.4
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	19.1
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	18.4
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	18.1
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	18.0
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	9.5
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	7.8
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	5.1
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