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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
: Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A 5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A 5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
1040.6
Number of samples
159
Samples
Sample
Description
FPKM
TCGA-DC-6155-01A
31 years, female, white, stage:iiia, alive, 425 days
3298.8
TCGA-AG-3609-01A
65 years, female, stage:iiic, alive, 608 days
2349.5
TCGA-AG-3583-01A
66 years, male, stage:iv, dead, 610 days
2140.1
TCGA-AG-3591-01A
66 years, female, stage:iia, alive, 1035 days
2013.3
TCGA-AG-3605-01A
85 years, female, stage:iv, alive, 30 days
1839.3
TCGA-AG-A02G-01A
66 years, male, stage:iv, dead, 1185 days
1772.2
TCGA-AG-A015-01A
64 years, female, stage:i, alive, 1096 days
1684.6
TCGA-AG-3574-01A
89 years, female, stage:ii, dead, 1096 days
1663.2
TCGA-AG-3999-01A
61 years, female, stage:iiic, alive, 853 days
1638.6
TCGA-AG-A016-01A
55 years, male, stage:iv, alive, 276 days
1587.9
TCGA-AG-3611-01A
72 years, male, stage:iia, alive, 424 days
1584.2
TCGA-AG-3587-01A
65 years, male, stage:i, alive, 1400 days
1580.5
TCGA-EI-6917-01A
33 years, male, white, stage:iiia, alive, 531 days
1526.1
TCGA-AF-4110-01A
77 years, male, white, stage:iva, alive, 912 days
1509.2
TCGA-AG-3598-01A
69 years, male, stage:iia, alive, 1522 days
1501.1
TCGA-AG-3600-01A
62 years, male, stage:iiic, alive, 184 days
1498.2
TCGA-DC-4745-01A
49 years, female, white, stage:iiib, alive, 639 days
1482.2
TCGA-AG-3608-01A
79 years, female, stage:iia, alive, 485 days
1463.4
TCGA-DY-A0XA-01A
57 years, female, white, stage:iia, alive, 3846 days
1449.5
TCGA-AG-3887-01A
68 years, male, stage:iia, alive, 1124 days
1433.9
TCGA-EI-6509-01A
53 years, male, white, stage:iiic, alive, 517 days
1418.1
TCGA-AG-3896-01A
85 years, female, stage:i, alive, 31 days
1377.9
TCGA-CI-6619-01B
41 years, male, white, stage:iv, alive, 184 days
1376.2
TCGA-AG-3894-01A
65 years, male, stage:iia, alive, 426 days
1369.8
TCGA-AG-3581-01A
63 years, male, stage:i, alive, 215 days
1346.5
TCGA-AF-2691-01A
48 years, female, white, stage:i, alive, 1309 days
1346.5
TCGA-DC-5337-01A
69 years, male, white, stage:i, alive, 792 days
1338.0
TCGA-AG-3883-01A
69 years, male, stage:i, alive, 31 days
1331.3
TCGA-EI-6885-01A
57 years, female, white, stage:iv, alive, 415 days
1303.5
TCGA-DC-6682-01A
57 years, male, white, stage:iia, alive, 762 days
1302.9
TCGA-AG-3882-01A
66 years, female, stage:i, alive, 608 days
1299.5
TCGA-AG-3892-01A
57 years, female, stage:i, alive, 396 days
1273.0
TCGA-F5-6863-01A
71 years, female, white, stage:iiib, dead, 361 days
1271.9
TCGA-AF-A56L-01A
48 years, female, black or african american, stage:iiic, alive, 2007 days
1265.2
TCGA-BM-6198-01A
73 years, male, white, stage:iiib, alive, 646 days
1264.5
TCGA-AG-3902-01A
61 years, male, stage:iia, alive, 974 days
1257.5
TCGA-AG-A023-01A
62 years, female, stage:iv, dead, 1581 days
1251.2
TCGA-AG-4005-01A
64 years, male, stage:iv, alive, 427 days
1238.3
TCGA-F5-6571-01A
62 years, female, white, stage:iia, alive, 1288 days
1236.3
TCGA-AG-3586-01A
72 years, female, stage:iii, alive, 31 days
1227.9
TCGA-EI-7004-01A
37 years, female, white, alive, 257 days
1215.5
TCGA-CL-5918-01A
90 years, female, white, stage:iia, alive, 218 days
1213.1
TCGA-F5-6861-01A
60 years, female, white, stage:iia, alive, 1160 days
1203.0
TCGA-AG-A02X-01A
77 years, male, stage:i, alive, 1247 days
1202.2
TCGA-AG-3580-01A
67 years, male, stage:i, alive, 244 days
1200.4
TCGA-AG-3612-01A
55 years, female, stage:iiib, alive, 608 days
1200.3
TCGA-AF-5654-01A
73 years, female, white, stage:i, dead, 512 days
1197.6
TCGA-EI-6507-01A
60 years, male, white, stage:iia, alive, 607 days
1186.1
TCGA-EI-6506-01A
78 years, female, white, stage:iia, alive, 625 days
1181.1
TCGA-AG-A014-01A
86 years, male, stage:i, alive, 485 days
1180.5
TCGA-F5-6864-01A
74 years, female, white, stage:iiib, alive, 379 days
1165.1
TCGA-AH-6549-01A
66 years, male, white, alive, 532 days
1156.8
TCGA-CI-6622-01A
74 years, male, white, stage:iib, alive, 1362 days
1150.7
TCGA-AG-A00Y-01A
68 years, male, stage:iia, alive, 700 days
1144.7
TCGA-AF-2693-01A
75 years, male, white, stage:i, alive, 1155 days
1128.4
TCGA-AG-4007-01A
87 years, male, stage:iv, alive, 31 days
1123.5
TCGA-AG-3885-01A
71 years, female, stage:iiib, alive, 546 days
1122.7
TCGA-AG-A008-01A
50 years, female, stage:i, alive, 424 days
1122.3
TCGA-AF-6136-01A
72 years, female, white, stage:iiib, alive, 741 days
1120.7
TCGA-F5-6814-01A
57 years, male, white, stage:iia, alive, 1131 days
1119.7
TCGA-AF-3400-01A
54 years, male, white, stage:iia, alive, 1049 days
1119.3
TCGA-AG-3878-01A
64 years, male, stage:i, alive, 30 days
1108.0
TCGA-G5-6641-01A
67 years, male, white, stage:iiia, alive, 804 days
1095.9
TCGA-CL-4957-01A
79 years, female, dead, 425 days
1089.7
TCGA-AG-A00C-01A
49 years, female, stage:iiib, alive, 183 days
1076.7
TCGA-F5-6813-01A
70 years, male, white, stage:iiic, dead, 598 days
1074.1
TCGA-AG-3909-01A
69 years, female, stage:iiib, alive, 608 days
1067.0
TCGA-AG-A025-01A
62 years, female, stage:i, alive, 1520 days
1050.6
TCGA-AH-6643-01A
50 years, male, white, stage:iiic, dead, 1314 days
1047.8
TCGA-EI-7002-01A
58 years, male, white, stage:iv, alive, 364 days
1045.9
TCGA-AF-6672-01A
43 years, male, white, stage:iv, alive, 748 days
1043.1
TCGA-AG-3575-01A
51 years, male, stage:ii, alive, 365 days
1038.8
TCGA-AG-3881-01A
83 years, female, stage:iia, alive, 579 days
1023.4
TCGA-G5-6572-01A
56 years, male, white, dead, 1432 days
1016.7
TCGA-DY-A1DD-01A
77 years, female, white, stage:iiib, dead, 1741 days
1004.1
TCGA-EI-6883-01A
63 years, male, white, stage:iic, alive, 350 days
996.8
TCGA-DC-6154-01A
57 years, female, white, stage:iva, alive, 365 days
990.0
TCGA-AG-3599-01A
70 years, male, stage:i, alive, 366 days
989.7
TCGA-EI-6512-01A
64 years, female, white, stage:iiib, alive, 538 days
986.6
TCGA-AH-6544-01A
60 years, male, white, alive, 1173 days
984.9
TCGA-AF-3911-01A
48 years, male, white, stage:iiic, alive, 1148 days
984.7
TCGA-AF-2690-01A
77 years, female, white, stage:iiic, dead, 524 days
984.5
TCGA-DC-4749-01A
57 years, male, white, stage:i, alive, 762 days
984.5
TCGA-EI-6514-01A
59 years, female, white, stage:iia, alive, 496 days
984.0
TCGA-DY-A1H8-01A
77 years, female, white, stage:iiia, dead, 992 days
981.5
TCGA-AG-3592-01A
68 years, male, stage:iia, alive, 1035 days
980.6
TCGA-DC-6681-01A
70 years, female, white, stage:iva, alive, 790 days
979.5
TCGA-DT-5265-01A
51 years, male, asian, stage:ii, alive, 384 days
973.7
TCGA-G5-6233-01A
74 years, male, white, dead, 556 days
971.3
TCGA-AG-A032-01A
68 years, male, stage:iiib, alive, 1157 days
955.4
TCGA-AG-3582-01A
75 years, male, stage:iv, dead, 1096 days
948.1
TCGA-AG-A01N-01A
68 years, female, stage:iv, alive, 943 days
940.2
TCGA-DY-A1DC-01A
72 years, female, white, stage:iia, dead, 1258 days
940.0
TCGA-EI-6884-01A
71 years, male, white, stage:iiia, alive, 328 days
930.9
TCGA-AG-4008-01A
63 years, male, stage:iia, alive, 518 days
926.3
TCGA-CI-6620-01A
41 years, female, white, stage:iva, alive, 1009 days
924.2
TCGA-AG-3728-01A
73 years, male, stage:iiib, alive, 912 days
923.7
TCGA-AG-3727-01A
78 years, female, stage:iii, alive, 30 days
920.4
TCGA-DY-A1DG-01A
75 years, male, white, stage:iva, dead, 1566 days
910.4
TCGA-EI-6510-01A
77 years, female, white, alive, 556 days
906.2
TCGA-AG-3594-01A
77 years, male, stage:iia, dead, 61 days
900.7
TCGA-EI-6881-01A
60 years, male, white, stage:iiia, alive, 499 days
890.6
TCGA-DC-6157-01A
48 years, male, black or african american, stage:i, alive, 1581 days
889.4
TCGA-AG-A026-01A
66 years, male, stage:ii, dead, 59 days
888.3
TCGA-DC-5869-01A
62 years, female, black or african american, stage:iiib, alive, 943 days
885.7
TCGA-CI-6623-01B
44 years, male, white, stage:i, alive, 1443 days
882.7
TCGA-F5-6812-01A
67 years, male, white, stage:iia, alive, 1110 days
878.3
TCGA-CI-6621-01A
63 years, male, white, stage:iiib, alive, 419 days
867.4
TCGA-AF-A56K-01A
56 years, male, black or african american, stage:iia, alive, 2635 days
866.9
TCGA-DY-A1DF-01A
73 years, female, white, stage:iiic, dead, 734 days
859.5
TCGA-AG-3890-01A
62 years, male, stage:i, alive, 518 days
855.4
TCGA-AG-3725-01A
90 years, female, stage:iii, alive, 638 days
854.5
TCGA-AG-3742-01A
85 years, female, stage:i, alive, 30 days
848.6
TCGA-AH-6903-01A
46 years, male, white, stage:iiib, alive, 592 days
844.8
TCGA-AH-6897-01A
48 years, male, white, stage:i, alive, 804 days
839.3
TCGA-AG-4022-01A
59 years, female, stage:ii, alive, 1400 days
825.8
TCGA-DC-6683-01A
43 years, male, white, stage:iiib, alive, 762 days
814.6
TCGA-EI-6513-01A
59 years, male, white, stage:iiib, alive, 497 days
810.5
TCGA-AH-6644-01A
73 years, male, white, alive, 838 days
785.7
TCGA-AG-3898-01A
61 years, male, stage:iia, alive, 1461 days
785.4
TCGA-AG-3893-01A
74 years, male, stage:iiib, alive, 1065 days
779.8
TCGA-AG-3901-01A
67 years, female, stage:iiib, alive, 761 days
777.6
TCGA-AF-A56N-01A
47 years, female, black or african american, stage:iia, alive, 360 days
774.5
TCGA-EF-5830-01A
54 years, male, white, stage:iib, alive, 106 days
774.0
TCGA-AG-3584-01A
60 years, male, stage:iv, dead, 730 days
746.8
TCGA-AG-3731-01A
65 years, male, stage:iv, alive, 1126 days
745.1
TCGA-G5-6235-01A
72 years, male, white, stage:iiib, alive, 1696 days
725.3
TCGA-AF-6655-01A
66 years, male, white, stage:iiia, alive, 609 days
702.8
TCGA-AG-A01J-01A
59 years, female, stage:iia, alive, 31 days
701.3
TCGA-F5-6811-01A
72 years, female, white, stage:iia, alive, 979 days
699.0
TCGA-EF-5831-01A
72 years, male, white, stage:iia, alive, 127 days
694.3
TCGA-AG-3578-01A
76 years, female, stage:iia, alive, 974 days
690.7
TCGA-AG-3593-01A
72 years, female, stage:iia, alive, 1035 days
687.1
TCGA-AG-4001-01A
74 years, female, stage:iia, alive, 1096 days
681.5
TCGA-DC-6160-01A
68 years, male, white, stage:i, alive, 1339 days
664.9
TCGA-F5-6465-01A
64 years, female, white, stage:iia, alive, 1506 days
655.0
TCGA-AG-A02N-01A
67 years, male, stage:ii, alive, 1885 days
654.4
TCGA-AF-2692-01A
54 years, female, white, stage:iia, alive, 412 days
639.0
TCGA-AG-3726-01A
63 years, female, stage:i, alive, 243 days
634.5
TCGA-AF-3913-01A
60 years, male, black or african american, stage:iv, dead, 316 days
621.8
TCGA-AG-4021-01A
84 years, female, stage:iv, dead, 121 days
612.4
TCGA-AG-A020-01A
57 years, female, stage:iii, alive, 31 days
608.2
TCGA-AH-6547-01A
79 years, female, white, dead, 76 days
597.8
TCGA-EI-6508-01A
48 years, female, white, stage:iiib, alive, 636 days
576.3
TCGA-AF-2687-01A
57 years, male, white, stage:iiic, alive, 1427 days
573.8
TCGA-F5-6464-01A
77 years, female, white, stage:iiic, dead, 303 days
561.1
TCGA-CL-5917-01A
71 years, female, white, stage:iiic, alive, 2376 days
560.3
TCGA-EI-6882-01A
59 years, male, white, stage:iia, alive, 262 days
547.5
TCGA-DC-6158-01A
70 years, male, white, stage:i, dead, 334 days
546.6
TCGA-AG-A036-01A
71 years, male, stage:iii, alive, 3562 days
533.2
TCGA-DC-6156-01A
62 years, male, white, stage:iva, alive, 943 days
522.4
TCGA-DY-A1DE-01A
56 years, female, white, stage:iia, alive, 3932 days
512.6
TCGA-CI-6624-01C
53 years, female, white, stage:i, alive, 1466 days
499.1
TCGA-AG-3732-01A
78 years, female, stage:i, alive, 1003 days
494.5
TCGA-AG-A00H-01A
75 years, male, stage:iia, alive, 790 days
486.5
TCGA-F5-6702-01A
71 years, male, white, stage:iva, alive, 869 days
465.4
TCGA-AG-A002-01A
35 years, male, stage:i, alive, 638 days
450.6
TCGA-EI-6511-01A
52 years, male, white, stage:iiib, alive, 482 days