Expression of CALR in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 406.26
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

372.0

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	948.4
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	693.8
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	661.8
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	599.8
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	565.4
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	563.6
TCGA-CL-4957-01A	79 years, female, dead, 425 days	539.0
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	529.5
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	513.6
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	496.5
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	491.0
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	488.4
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	486.8
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	485.9
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	483.5
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	465.5
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	461.2
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	456.6
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	455.1
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	450.5
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	449.6
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	443.2
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	443.0
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	442.1
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	441.3
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	439.3
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	436.3
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	436.1
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	435.2
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	432.8
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	432.6
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	432.3
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	431.7
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	428.6
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	426.8
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	425.9
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	423.0
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	419.6
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	419.3
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	418.8
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	418.8
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	417.5
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	414.2
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	413.5
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	411.8
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	410.3
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	408.7
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	408.3
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	408.2
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	408.1
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	404.4
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	404.3
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	400.6
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	399.6
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	394.6
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	392.0
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	391.2
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	390.5
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	389.9
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	389.5
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	389.2
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	388.6
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	386.6
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	386.1
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	385.2
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	384.9
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	384.7
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	384.3
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	383.3
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	381.5
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	381.0
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	378.5
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	377.5
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	376.9
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	376.1
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	374.8
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	369.6
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	369.2
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	368.7
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	367.9
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	365.4
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	364.2
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	363.0
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	360.5
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	359.8
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	359.6
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	357.8
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	357.3
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	356.4
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	355.0
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	354.0
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	353.8
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	353.7
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	351.7
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	351.7
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	348.1
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	347.2
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	343.8
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	343.6
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	337.5
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	336.1
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	335.7
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	335.2
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	332.2
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	332.2
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	332.1
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	328.6
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	326.6
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	324.4
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	322.7
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	321.8
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	316.7
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	316.3
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	312.2
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	311.5
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	307.6
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	307.0
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	302.8
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	300.7
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	298.1
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	298.0
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	297.0
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	296.1
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	295.3
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	294.8
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	294.4
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	293.0
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	292.7
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	290.7
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	290.4
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	290.0
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	288.2
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	288.0
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	287.4
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	286.9
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	281.6
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	277.1
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	275.0
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	274.7
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	274.7
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	274.3
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	273.8
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	269.5
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	268.7
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	268.5
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	267.9
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	267.2
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	264.1
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	263.6
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	263.5
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	262.7
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	260.6
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	249.1
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	241.7
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	240.0
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	233.9
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	219.9
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	209.0
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	149.4
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