Expression of MT-ND5 in melanoma - The Human Protein Atlas

MELANOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

MT-ND5 is not prognostic in melanoma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 2139.63
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

2362.7

Number of samples

102

Samples

Sample	Description	FPKM
TCGA-DA-A960-01A	73 years, male, white, stage:iib, alive, 804 days	15932.1
TCGA-D3-A5GT-01A	43 years, male, white, stage:iiic, alive, 487 days	8803.0
TCGA-EB-A553-01A	62 years, male, white, stage:iic, alive, 226 days	8412.8
TCGA-ER-A194-01A	77 years, male, white, dead, 1354 days	5904.7
TCGA-EB-A85I-01A	66 years, male, white, stage:iic, alive, 362 days	5895.4
TCGA-YG-AA3N-01A	67 years, male, stage:iic, alive, 306 days	5627.4
TCGA-EB-A5UM-01A	48 years, female, white, stage:iic, alive, 779 days	5335.8
TCGA-EB-A4OY-01A	65 years, female, white, stage:iiib, alive, 977 days	5226.8
TCGA-EB-A4OZ-01A	42 years, female, white, stage:iiic, alive, 620 days	5035.7
TCGA-EB-A551-01A	78 years, female, white, stage:iiic, alive, 590 days	4783.7
TCGA-EB-A24D-01A	72 years, male, white, stage:iiib, alive, 645 days	4735.8
TCGA-BF-A5ER-01A	63 years, male, white, stage:iic, alive, 327 days	4320.5
TCGA-D9-A4Z5-01A	68 years, male, white, stage:iib, alive, 218 days	4227.7
TCGA-EB-A3XB-01A	63 years, male, white, stage:ii, alive, 796 days	4210.2
TCGA-EB-A41A-01A	90 years, male, white, stage:iic, alive, 262 days	4002.8
TCGA-GN-A263-01A	24 years, male, white, stage:iv, dead, 467 days	4002.5
TCGA-BF-AAP7-01A	76 years, female, white, stage:iic, alive, 318 days	3757.2
TCGA-BF-A5EQ-01A	63 years, male, white, stage:iic, alive, 323 days	3629.3
TCGA-BF-A3DL-01A	84 years, female, white, stage:iiib, alive, 769 days	3334.8
TCGA-BF-AAOU-01A	73 years, female, white, stage:iic, alive, 476 days	3310.0
TCGA-FR-A728-01A	54 years, female, white, stage:iiib, alive, 583 days	3084.4
TCGA-FW-A5DX-01A	71 years, male, white, stage:iiic, alive, 640 days	3051.6
TCGA-HR-A5NC-01A	90 years, female, alive, 1000 days	3040.5
TCGA-BF-A1PX-01A	56 years, male, white, stage:iiib, dead, 282 days	2968.7
TCGA-BF-A9VF-01A	77 years, male, white, stage:iic, alive, 440 days	2958.1
TCGA-XV-AAZW-01A	62 years, female, white, stage:ii, dead, 393 days	2887.5
TCGA-EB-A3XE-01A	77 years, female, white, stage:iia, alive, 180 days	2803.6
TCGA-BF-A5EP-01A	75 years, female, white, stage:iiic, alive, 335 days	2764.2
TCGA-EB-A44P-01A	58 years, female, white, stage:iic, alive, 741 days	2726.5
TCGA-EB-A6QY-01A	71 years, male, white, stage:iic, alive, 382 days	2717.0
TCGA-GN-A4U5-01A	61 years, female, white, stage:ib, alive, 1156 days	2667.6
TCGA-EB-A5FP-01A	65 years, female, white, stage:iv, dead, 454 days	2628.9
TCGA-XV-AAZY-01A	76 years, female, white, stage:iiic, alive, 405 days	2566.1
TCGA-BF-AAP8-01A	58 years, male, white, stage:iic, alive, 447 days	2356.0
TCGA-EB-A42Z-01A	49 years, male, asian, stage:iiic, alive, 441 days	2259.1
TCGA-EB-A3Y6-01A	56 years, female, white, stage:iic, alive, 126 days	2245.9
TCGA-EB-A3XD-01A	53 years, female, white, stage:iic, alive, 1160 days	2153.6
TCGA-XV-A9W5-01A	51 years, male, white, stage:i/ii nos, alive, 392 days	2143.9
TCGA-EB-A97M-01A	66 years, male, white, stage:iic, alive, 414 days	2140.5
TCGA-FR-A726-01A	90 years, male, white, stage:iic, dead, 305 days	2138.8
TCGA-BF-AAOX-01A	83 years, male, white, stage:iic, alive, 444 days	2070.5
TCGA-D9-A4Z2-01A	50 years, male, white, stage:iiic, dead, 190 days	2061.7
TCGA-GF-A2C7-01A	48 years, male, white, stage:iic, alive, 21 days	2059.3
TCGA-ER-A19K-01A	79 years, female, white, stage:iic, dead, 469 days	2029.7
TCGA-EB-A24C-01A	56 years, male, white, alive, 632 days	1994.8
TCGA-BF-A5EO-01A	65 years, male, white, stage:iic, alive, 703 days	1968.4
TCGA-EB-A3Y7-01A	86 years, female, white, stage:iiib, dead, 326 days	1959.4
TCGA-XV-AAZV-01A	56 years, female, white, stage:ii, alive, 412 days	1949.7
TCGA-EB-A6QZ-01A	76 years, female, white, stage:iia, dead, 352 days	1884.5
TCGA-EB-A4IS-01A	77 years, male, white, stage:iib, alive, 774 days	1835.0
TCGA-EB-A3HV-01A	37 years, male, white, stage:iic, alive, 39 days	1739.7
TCGA-XV-A9W2-01A	81 years, male, white, stage:i, alive, 417 days	1739.6
TCGA-EB-A4P0-01A	82 years, male, white, stage:iic, dead, 326 days	1737.4
TCGA-EB-A57M-01A	56 years, male, asian, stage:iiib, dead, 472 days	1732.6
TCGA-EB-A431-01A	34 years, male, white, stage:iic, alive, 568 days	1728.5
TCGA-EB-A1NK-01A	48 years, male, white, stage:iic, alive, 1039 days	1724.4
TCGA-EB-A299-01A	63 years, male, white, stage:iia, alive, 378 days	1700.1
TCGA-WE-A8K4-01A	85 years, male, white, stage:iib, alive, 614 days	1696.8
TCGA-FS-A1ZN-01A	43 years, male, white, stage:iiia, dead, 730 days	1629.7
TCGA-GN-A8LN-01A	68 years, male, white, stage:iic, alive, 772 days	1575.1
TCGA-D9-A3Z4-01A	54 years, male, white, stage:iiic, dead, 519 days	1567.0
TCGA-IH-A3EA-01A	61 years, male, white, stage:iic, alive, 524 days	1553.5
TCGA-BF-A1PZ-01A	71 years, female, white, stage:iib, alive, 853 days	1551.4
TCGA-BF-AAP4-01A	61 years, male, white, stage:iic, alive, 335 days	1536.1
TCGA-FR-A2OS-01A	49 years, female, white, stage:iic, dead, 368 days	1508.4
TCGA-BF-AAP2-01A	62 years, male, white, stage:iib, alive, 405 days	1480.1
TCGA-BF-A3DJ-01A	36 years, female, white, stage:iiib, alive, 464 days	1474.2
TCGA-BF-AAP1-01A	86 years, male, white, stage:iic, alive, 409 days	1459.1
TCGA-D9-A4Z3-01A	73 years, female, white, stage:iiic, alive, 505 days	1378.9
TCGA-BF-A5ES-01A	76 years, female, white, stage:iic, alive, 490 days	1376.3
TCGA-EB-A51B-01A	53 years, male, white, stage:iic, alive, 931 days	1359.6
TCGA-EB-A4IQ-01A	42 years, female, asian, stage:iiib, dead, 636 days	1354.7
TCGA-EB-A5SF-01A	78 years, female, white, stage:iic, dead, 369 days	1335.5
TCGA-EB-A82B-01A	58 years, female, asian, stage:iii, alive, 390 days	1285.5
TCGA-EB-A4XL-01A	56 years, female, white, stage:iic, alive, 777 days	1262.6
TCGA-BF-AAP6-01A	55 years, male, white, stage:iii, alive, 325 days	1210.6
TCGA-ER-A2NB-01A	57 years, male, white, stage:iiib, dead, 857 days	1118.9
TCGA-BF-A3DN-01A	81 years, female, white, stage:iiic, alive, 717 days	1083.7
TCGA-ER-A2NF-01A	53 years, male, white, stage:iiib, dead, 877 days	1026.9
TCGA-EB-A85J-01A	66 years, female, white, stage:iib, alive, 360 days	1012.5
TCGA-EB-A550-01A	75 years, female, white, stage:iic, dead, 264 days	982.5
TCGA-BF-A1PU-01A	46 years, female, white, stage:iic, alive, 387 days	971.5
TCGA-EB-A3XF-01A	57 years, male, white, stage:iic, alive, 278 days	965.9
TCGA-EB-A6R0-01A	58 years, female, white, stage:iic, dead, 608 days	908.3
TCGA-EB-A44N-01A	59 years, male, white, stage:iic, dead, 205 days	892.0
TCGA-GF-A769-01A	39 years, male, white, stage:iic, dead, 1070 days	877.1
TCGA-EB-A82C-01A	70 years, female, asian, stage:iic, alive, 17 days	845.8
TCGA-EB-A5VU-01A	56 years, male, asian, stage:iiib, dead, 321 days	840.9
TCGA-XV-A9VZ-01A	90 years, female, white, stage:ii, alive, 11 days	819.5
TCGA-BF-A1PV-01A	74 years, female, white, stage:iic, alive, 14 days	757.4
TCGA-EB-A44O-01A	69 years, male, white, stage:iib, alive, 81 days	714.8
TCGA-FR-A3R1-01A	69 years, male, white, stage:iic, alive, 685 days	664.5
TCGA-EB-A42Y-01A	73 years, female, asian, stage:iic, dead, 721 days	651.0
TCGA-ER-A196-01A	64 years, female, white, stage:iic, alive, 1785 days	613.6
TCGA-BF-A1Q0-01A	80 years, male, white, stage:iic, alive, 831 days	501.4
TCGA-ER-A19T-01A	51 years, male, white, stage:iv, dead, 270 days	490.9
TCGA-EB-A41B-01A	76 years, female, white, stage:iic, alive, 291 days	455.0
TCGA-EB-A5SE-01A	73 years, male, white, stage:iib, dead, 401 days	394.0
TCGA-EB-A3XC-01A	74 years, male, white, stage:iic, alive, 650 days	319.7
TCGA-GN-A26C-01A	77 years, male, white, stage:iiic, dead, 821 days	310.8
TCGA-BF-A3DM-01A	63 years, male, white, stage:iia, alive, 601 days	245.9
TCGA-ER-A42H-01A	77 years, male, white, dead, 426 days	238.3
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MELANOMA - Protein expressionⁱ

Pending cancer tissue analysis