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PANCREATIC CANCER - Interactive survival scatter ploti
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
: Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A 5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A 5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average FPKM
4473.3
Number of samples
176
Samples
Sample
Description
FPKM
TCGA-FB-AAQ3-01A
65 years, female, white, stage:iib, dead, 31 days
16556.0
TCGA-2L-AAQM-01A
52 years, male, white, stage:iib, alive, 1383 days
15282.2
TCGA-3A-A9IV-01A
59 years, female, white, stage:ib, alive, 1103 days
14260.7
TCGA-HV-A7OP-01A
72 years, male, asian, stage:iib, alive, 978 days
11070.1
TCGA-LB-A7SX-01A
74 years, female, black or african american, stage:iib, dead, 393 days
10835.7
TCGA-US-A779-01A
54 years, female, white, stage:iib, dead, 511 days
9711.2
TCGA-Q3-AA2A-01A
64 years, female, white, stage:ib, alive, 95 days
9341.8
TCGA-FB-AAPY-01A
71 years, male, white, stage:iib, dead, 1059 days
9329.7
TCGA-2J-AABK-01A
71 years, male, white, stage:iib, alive, 484 days
9323.2
TCGA-2J-AABH-01A
61 years, male, white, stage:iia, alive, 1287 days
9222.8
TCGA-HZ-A49H-01A
68 years, female, white, stage:iib, alive, 491 days
8452.2
TCGA-H8-A6C1-01A
53 years, male, white, stage:iia, alive, 671 days
8435.5
TCGA-FB-AAQ1-01A
49 years, male, white, stage:iib, dead, 123 days
8248.9
TCGA-2L-AAQL-01A
82 years, male, white, stage:iib, dead, 292 days
7997.3
TCGA-HV-A5A6-01A
65 years, female, asian, stage:iib, dead, 2036 days
7918.3
TCGA-2J-AABT-01A
72 years, female, white, stage:iib, alive, 319 days
7905.5
TCGA-HV-A5A5-01A
61 years, female, asian, stage:iib, alive, 289 days
7778.1
TCGA-IB-7649-01A
73 years, female, stage:iib, dead, 467 days
7622.0
TCGA-2L-AAQJ-01A
49 years, female, white, stage:iii, dead, 394 days
7620.9
TCGA-F2-A44H-01A
65 years, male, white, stage:iia, alive, 586 days
7550.1
TCGA-3A-A9IL-01A
39 years, female, white, stage:i, alive, 2741 days
7246.4
TCGA-Q3-A5QY-01A
58 years, male, white, stage:iib, alive, 416 days
7230.6
TCGA-FB-AAPP-01A
71 years, male, white, stage:iib, dead, 485 days
7080.7
TCGA-HZ-A8P1-01A
81 years, male, white, stage:ib, alive, 7 days
7048.1
TCGA-3A-A9IN-01A
62 years, female, white, stage:ib, alive, 2084 days
6950.5
TCGA-IB-A5SP-01A
77 years, male, white, stage:iia, alive, 482 days
6851.8
TCGA-F2-A8YN-01A
76 years, male, white, stage:iia, alive, 517 days
6765.2
TCGA-RB-A7B8-01A
81 years, female, white, stage:iib, dead, 466 days
6624.9
TCGA-3E-AAAY-01A
67 years, male, white, stage:iib, alive, 2285 days
6520.8
TCGA-FB-AAPU-01A
41 years, female, asian, stage:iia, dead, 381 days
6499.1
TCGA-HZ-A77P-01A
77 years, male, white, stage:iib, alive, 330 days
6398.1
TCGA-HZ-8637-01A
76 years, female, white, stage:iib, dead, 517 days
6178.7
TCGA-F2-A44G-01A
79 years, female, white, stage:iib, dead, 233 days
6076.6
TCGA-XD-AAUH-01A
57 years, female, white, stage:iib, alive, 395 days
6074.5
TCGA-HZ-8519-01A
73 years, male, white, stage:ia, alive, 454 days
6070.6
TCGA-RL-AAAS-01A
60 years, female, white, stage:ib, alive, 9 days
5957.8
TCGA-FB-AAPZ-01A
54 years, male, white, stage:iib, alive, 716 days
5909.4
TCGA-PZ-A5RE-01A
44 years, female, white, stage:iib, dead, 470 days
5901.9
TCGA-3A-A9I9-01A
67 years, male, white, stage:iia, dead, 634 days
5770.3
TCGA-2L-AAQE-01A
56 years, male, white, stage:iib, dead, 684 days
5578.5
TCGA-HZ-8315-01A
54 years, female, white, stage:iia, dead, 299 days
5544.9
TCGA-FB-AAQ2-01A
81 years, female, white, stage:iib, dead, 153 days
5465.7
TCGA-FB-AAPS-01A
62 years, female, white, stage:iib, alive, 228 days
5462.0
TCGA-M8-A5N4-01A
48 years, female, stage:iia, alive, 584 days
5453.5
TCGA-F2-6880-01A
70 years, male, white, stage:iib, alive, 289 days
5401.3
TCGA-3A-A9IS-01A
67 years, male, white, stage:ib, alive, 998 days
5358.5
TCGA-HV-AA8V-01A
50 years, male, asian, stage:iib, alive, 920 days
5248.6
TCGA-FB-A7DR-01A
48 years, male, asian, stage:iia, dead, 353 days
5190.1
TCGA-HZ-7289-01A
77 years, male, white, stage:iib, dead, 661 days
5147.6
TCGA-2J-AABE-01A
73 years, male, white, stage:iia, alive, 676 days
5134.9
TCGA-2J-AAB1-01A
65 years, male, white, stage:iib, dead, 66 days
5113.8
TCGA-2J-AABA-01A
55 years, male, white, stage:iib, dead, 607 days
5079.8
TCGA-2J-AABO-01A
43 years, male, white, stage:iib, alive, 440 days
5026.4
TCGA-HZ-8317-01A
69 years, female, white, stage:iib, dead, 378 days
4985.4
TCGA-XN-A8T5-01A
53 years, female, white, stage:ib, alive, 720 days
4932.9
TCGA-IB-7889-01A
86 years, female, white, stage:iib, dead, 481 days
4894.8
TCGA-US-A77E-01A
73 years, male, white, stage:iib, dead, 430 days
4820.4
TCGA-XD-AAUG-01A
66 years, female, white, stage:iv, alive, 420 days
4713.0
TCGA-IB-AAUR-01A
67 years, male, white, stage:iib, alive, 338 days
4684.2
TCGA-3A-A9IJ-01A
65 years, male, white, stage:ib, alive, 1854 days
4674.9
TCGA-HV-A5A3-01A
50 years, male, asian, stage:iia, dead, 128 days
4644.7
TCGA-2J-AABU-01A
56 years, male, white, stage:iib, dead, 277 days
4598.2
TCGA-IB-AAUM-01A
76 years, male, white, stage:iib, alive, 8 days
4594.5
TCGA-3A-A9I7-01A
45 years, male, black or african american, stage:iib, alive, 1323 days
4589.0
TCGA-S4-A8RO-01A
75 years, female, white, stage:iib, alive, 525 days
4532.6
TCGA-FB-A4P5-01A
69 years, female, white, stage:iib, dead, 179 days
4523.5
TCGA-2J-AAB8-01A
71 years, male, white, stage:iib, alive, 80 days
4474.0
TCGA-3A-A9I5-01A
58 years, male, white, alive, 1794 days
4460.5
TCGA-XD-AAUI-01A
50 years, female, white, stage:iib, dead, 366 days
4425.3
TCGA-HV-AA8X-01A
75 years, female, asian, stage:iib, dead, 532 days
4404.6
TCGA-3A-A9IR-01A
64 years, female, white, stage:ib, alive, 1542 days
4399.7
TCGA-HZ-A4BK-01A
72 years, male, white, stage:iib, alive, 657 days
4398.0
TCGA-HZ-8001-01A
69 years, male, white, stage:iii, alive, 706 days
4398.0
TCGA-FB-AAQ0-01A
68 years, male, white, stage:iia, dead, 473 days
4365.6
TCGA-FB-AAQ6-01A
85 years, male, white, stage:ia, dead, 244 days
4286.4
TCGA-IB-AAUO-01A
64 years, female, white, stage:iib, dead, 239 days
4277.7
TCGA-IB-AAUQ-01A
50 years, male, white, stage:iib, dead, 183 days
4256.6
TCGA-US-A77J-01A
81 years, female, white, stage:iib, dead, 568 days
4253.6
TCGA-S4-A8RM-01A
67 years, male, white, stage:iib, alive, 737 days
4242.9
TCGA-OE-A75W-01A
75 years, male, white, stage:iia, dead, 267 days
4205.8
TCGA-IB-A6UG-01A
65 years, male, white, stage:iib, dead, 41 days
4170.6
TCGA-US-A776-01A
61 years, male, white, stage:iia, alive, 1216 days
4120.6
TCGA-US-A77G-01A
64 years, male, white, stage:iib, dead, 12 days
4118.1
TCGA-FB-A5VM-01A
74 years, male, white, stage:ib, dead, 498 days
4101.8
TCGA-XN-A8T3-01A
67 years, male, white, stage:ib, alive, 951 days
4084.9
TCGA-IB-A5SO-01A
71 years, male, white, stage:iib, dead, 365 days
4015.2
TCGA-IB-A7M4-01A
81 years, male, white, stage:iib, alive, 483 days
3996.0
TCGA-YB-A89D-01A
59 years, male, white, stage:iib, alive, 350 days
3988.1
TCGA-HZ-8638-01A
84 years, female, white, stage:ia, dead, 151 days
3982.3
TCGA-HZ-A77Q-01A
55 years, female, white, stage:iib, alive, 33 days
3925.9
TCGA-Z5-AAPL-01A
74 years, female, white, stage:iia, alive, 467 days
3898.9
TCGA-3A-A9IX-01A
40 years, male, white, stage:ia, alive, 1037 days
3890.4
TCGA-HZ-A9TJ-01A
70 years, male, white, stage:iv, alive, 603 days
3887.1
TCGA-S4-A8RP-01A
77 years, female, white, stage:iib, dead, 702 days
3867.2
TCGA-2J-AABV-01A
74 years, male, white, stage:iib, dead, 652 days
3824.3
TCGA-H6-A45N-01A
88 years, female, white, stage:iib, dead, 421 days
3793.0
TCGA-IB-AAUW-01A
63 years, female, white, stage:iib, dead, 230 days
3789.8
TCGA-HZ-A77O-01A
77 years, female, white, stage:iib, dead, 160 days
3729.8
TCGA-2J-AAB9-01A
71 years, female, white, stage:iib, dead, 627 days
3725.7
TCGA-2J-AABI-01A
55 years, female, white, stage:iia, alive, 969 days
3721.8
TCGA-3A-A9IB-01A
69 years, female, white, stage:iib, dead, 224 days
3710.2
TCGA-IB-A6UF-01A
63 years, male, white, stage:iib, alive, 666 days
3693.1
TCGA-IB-8126-01A
80 years, female, white, stage:iii, alive, 462 days
3689.3
TCGA-2L-AAQI-01A
66 years, male, white, stage:iib, dead, 103 days
3672.3
TCGA-IB-AAUV-01A
49 years, male, white, stage:iib, alive, 404 days
3642.2
TCGA-3A-A9IO-01A
56 years, male, white, alive, 1942 days
3619.9
TCGA-FB-A545-01A
72 years, female, white, stage:iib, dead, 732 days
3549.7
TCGA-3A-A9IH-01A
66 years, female, white, stage:ia, alive, 1021 days
3454.9
TCGA-RB-AA9M-01A
43 years, male, white, stage:iib, alive, 286 days
3453.0
TCGA-FB-A78T-01A
71 years, female, white, stage:iib, dead, 375 days
3438.7
TCGA-2J-AAB4-01A
48 years, male, white, stage:iib, alive, 729 days
3416.8
TCGA-3E-AAAZ-01A
71 years, male, white, stage:iia, dead, 2182 days
3415.4
TCGA-2J-AABR-01A
60 years, female, white, stage:iia, alive, 438 days
3375.0
TCGA-IB-A7LX-01A
57 years, male, white, stage:iib, dead, 250 days
3365.6
TCGA-HV-A5A4-01A
72 years, female, asian, stage:iia, alive, 232 days
3356.2
TCGA-IB-A5ST-01A
64 years, female, white, stage:iib, alive, 635 days
3306.0
TCGA-IB-7645-01A
44 years, female, stage:iib, dead, 1502 days
3304.2
TCGA-IB-AAUS-01A
84 years, female, white, stage:iib, alive, 225 days
3258.0
TCGA-2J-AABF-01A
73 years, male, white, stage:iib, dead, 691 days
3228.6
TCGA-IB-AAUU-01A
35 years, male, white, stage:iib, alive, 245 days
3223.9
TCGA-HZ-A49G-01A
58 years, female, white, stage:iib, alive, 660 days
3195.6
TCGA-YH-A8SY-01A
73 years, female, white, alive, 388 days
3184.5
TCGA-US-A774-01A
76 years, female, white, stage:iib, dead, 695 days
3069.1
TCGA-IB-7644-01A
65 years, female, white, stage:iv, dead, 394 days
2948.2
TCGA-L1-A7W4-01A
48 years, female, white, stage:iib, dead, 278 days
2933.2
TCGA-IB-7897-01A
54 years, female, white, stage:iib, dead, 486 days
2887.9
TCGA-3A-A9J0-01A
75 years, male, white, stage:iib, alive, 743 days
2859.3
TCGA-LB-A8F3-01A
64 years, female, black or african american, stage:iia, alive, 379 days
2785.4
TCGA-IB-AAUP-01A
68 years, male, white, stage:iib, alive, 431 days
2772.4
TCGA-IB-AAUN-01A
74 years, female, white, stage:ib, dead, 144 days
2759.3
TCGA-IB-AAUT-01A
65 years, male, white, stage:iib, alive, 287 days
2740.4
TCGA-YY-A8LH-01A
61 years, female, white, stage:iib, alive, 2016 days
2733.4
TCGA-FB-AAPQ-01A
65 years, male, white, stage:iib, dead, 1130 days
2724.3
TCGA-XD-AAUL-01A
56 years, male, white, stage:iia, alive, 498 days
2710.6
TCGA-IB-A5SQ-01A
56 years, female, white, stage:ib, dead, 219 days
2707.9
TCGA-FB-A4P6-01A
54 years, male, white, stage:iib, alive, 767 days
2698.8
TCGA-HZ-7923-01A
65 years, male, white, stage:iia, alive, 314 days
2676.5
TCGA-HZ-8002-01A
61 years, male, white, stage:iib, dead, 366 days
2646.3
TCGA-F2-A7TX-01A
77 years, male, white, stage:iib, dead, 95 days
2613.3
TCGA-F2-7276-01A
64 years, male, white, stage:iib, dead, 216 days
2539.7
TCGA-IB-7646-01A
60 years, male, white, stage:iib, dead, 145 days
2524.9
TCGA-LB-A9Q5-01A
63 years, female, white, stage:iib, dead, 313 days
2517.4
TCGA-IB-7885-01A
78 years, female, white, stage:iib, alive, 1257 days
2488.5
TCGA-HZ-A4BH-01A
75 years, male, white, stage:iib, alive, 194 days
2425.9
TCGA-HZ-7925-01A
66 years, male, white, stage:iib, dead, 614 days
2398.1
TCGA-IB-7654-01A
80 years, male, white, stage:iib, dead, 476 days
2362.1
TCGA-HZ-7924-01A
60 years, female, white, stage:iia, alive, 840 days
2361.4
TCGA-3A-A9IU-01A
65 years, male, white, stage:iib, dead, 458 days
2305.0
TCGA-3A-A9IC-01A
61 years, female, white, stage:iib, dead, 738 days
2267.1
TCGA-IB-7651-01A
64 years, female, white, stage:iib, dead, 603 days
2243.3
TCGA-H6-8124-01A
56 years, female, white, stage:iib, alive, 392 days
2188.7
TCGA-HZ-8636-01A
58 years, female, white, stage:iv, dead, 545 days
2184.3
TCGA-F2-6879-01A
57 years, male, white, stage:iib, dead, 334 days
2156.1
TCGA-HZ-7926-01A
57 years, male, black or african american, stage:iib, dead, 518 days
2145.2
TCGA-HZ-8003-01A
65 years, female, white, stage:iib, dead, 596 days
2138.9
TCGA-IB-7891-01A
49 years, female, white, stage:iib, dead, 913 days
2097.7
TCGA-IB-7887-01A
62 years, female, white, stage:iib, dead, 110 days
2094.1
TCGA-HZ-A49I-01A
77 years, male, white, stage:iib, dead, 308 days
2073.9
TCGA-2L-AAQA-01A
76 years, male, white, stage:iib, dead, 143 days
2026.8
TCGA-IB-7888-01A
66 years, female, black or african american, stage:iia, dead, 1332 days
1989.7
TCGA-IB-7652-01A
49 years, female, asian, stage:iib, alive, 1116 days
1937.0
TCGA-IB-8127-01A
59 years, male, white, stage:iib, alive, 522 days
1908.8
TCGA-HZ-7919-01A
52 years, female, white, stage:iib, dead, 593 days
1813.2
TCGA-2J-AAB6-01A
75 years, male, white, stage:iia, dead, 293 days
1753.4
TCGA-HV-A7OL-01A
70 years, male, asian, stage:iia, alive, 252 days
1746.8
TCGA-HZ-7918-01A
72 years, male, white, stage:iib, alive, 969 days
1638.8
TCGA-2J-AABP-01A
58 years, female, white, stage:iib, alive, 463 days
1627.6
TCGA-IB-7893-01A
64 years, male, white, stage:iia, dead, 117 days
1606.0
TCGA-HZ-7920-01A
71 years, male, white, stage:ib, dead, 236 days
1523.0
TCGA-IB-7890-01A
73 years, male, stage:ib, dead, 598 days
1517.6
TCGA-IB-A5SS-01A
64 years, female, white, stage:iib, dead, 460 days
1430.5
TCGA-F2-7273-01A
54 years, male, black or african american, stage:iib, dead, 592 days
1428.3
TCGA-3A-A9IZ-01A
47 years, male, white, stage:iib, dead, 308 days
1337.9
TCGA-HZ-7922-01A
61 years, female, white, stage:iib, alive, 4 days
1310.7
TCGA-HZ-8005-01A
81 years, male, white, stage:iib, dead, 120 days
976.9
TCGA-IB-7886-01A
80 years, male, white, stage:iib, dead, 123 days
907.7
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PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells.