Expression of HLA-A in melanoma - The Human Protein Atlas

MELANOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

HLA-A is not prognostic in melanoma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 400.36
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

927.1

Number of samples

102

Samples

Sample	Description	FPKM
TCGA-BF-AAOX-01A	83 years, male, white, stage:iic, alive, 444 days	3529.6
TCGA-ER-A19K-01A	79 years, female, white, stage:iic, dead, 469 days	3015.3
TCGA-EB-A85I-01A	66 years, male, white, stage:iic, alive, 362 days	2945.4
TCGA-EB-A4P0-01A	82 years, male, white, stage:iic, dead, 326 days	2470.4
TCGA-BF-A5ES-01A	76 years, female, white, stage:iic, alive, 490 days	2394.5
TCGA-EB-A4IS-01A	77 years, male, white, stage:iib, alive, 774 days	2372.3
TCGA-EB-A4OZ-01A	42 years, female, white, stage:iiic, alive, 620 days	2329.4
TCGA-EB-A51B-01A	53 years, male, white, stage:iic, alive, 931 days	2141.7
TCGA-BF-AAP4-01A	61 years, male, white, stage:iic, alive, 335 days	2124.5
TCGA-BF-AAP7-01A	76 years, female, white, stage:iic, alive, 318 days	2095.8
TCGA-GN-A4U5-01A	61 years, female, white, stage:ib, alive, 1156 days	2031.2
TCGA-XV-AAZY-01A	76 years, female, white, stage:iiic, alive, 405 days	1970.3
TCGA-EB-A97M-01A	66 years, male, white, stage:iic, alive, 414 days	1889.2
TCGA-WE-A8K4-01A	85 years, male, white, stage:iib, alive, 614 days	1861.1
TCGA-FR-A728-01A	54 years, female, white, stage:iiib, alive, 583 days	1742.3
TCGA-EB-A6R0-01A	58 years, female, white, stage:iic, dead, 608 days	1621.5
TCGA-GN-A26C-01A	77 years, male, white, stage:iiic, dead, 821 days	1618.6
TCGA-EB-A3XB-01A	63 years, male, white, stage:ii, alive, 796 days	1596.9
TCGA-ER-A194-01A	77 years, male, white, dead, 1354 days	1562.9
TCGA-IH-A3EA-01A	61 years, male, white, stage:iic, alive, 524 days	1459.9
TCGA-EB-A3Y6-01A	56 years, female, white, stage:iic, alive, 126 days	1443.1
TCGA-EB-A85J-01A	66 years, female, white, stage:iib, alive, 360 days	1405.8
TCGA-BF-A3DJ-01A	36 years, female, white, stage:iiib, alive, 464 days	1303.9
TCGA-BF-A1PX-01A	56 years, male, white, stage:iiib, dead, 282 days	1271.3
TCGA-EB-A3XC-01A	74 years, male, white, stage:iic, alive, 650 days	1251.2
TCGA-BF-AAP8-01A	58 years, male, white, stage:iic, alive, 447 days	1249.5
TCGA-EB-A3XF-01A	57 years, male, white, stage:iic, alive, 278 days	1240.7
TCGA-EB-A4OY-01A	65 years, female, white, stage:iiib, alive, 977 days	1148.3
TCGA-ER-A2NF-01A	53 years, male, white, stage:iiib, dead, 877 days	1128.8
TCGA-EB-A3XE-01A	77 years, female, white, stage:iia, alive, 180 days	1123.4
TCGA-XV-AAZV-01A	56 years, female, white, stage:ii, alive, 412 days	1120.0
TCGA-EB-A551-01A	78 years, female, white, stage:iiic, alive, 590 days	1115.4
TCGA-EB-A82B-01A	58 years, female, asian, stage:iii, alive, 390 days	1097.4
TCGA-BF-A5EQ-01A	63 years, male, white, stage:iic, alive, 323 days	1057.4
TCGA-FR-A3R1-01A	69 years, male, white, stage:iic, alive, 685 days	1035.9
TCGA-EB-A24D-01A	72 years, male, white, stage:iiib, alive, 645 days	989.8
TCGA-BF-AAP2-01A	62 years, male, white, stage:iib, alive, 405 days	961.1
TCGA-DA-A960-01A	73 years, male, white, stage:iib, alive, 804 days	923.4
TCGA-XV-A9W5-01A	51 years, male, white, stage:i/ii nos, alive, 392 days	915.2
TCGA-GN-A263-01A	24 years, male, white, stage:iv, dead, 467 days	910.7
TCGA-EB-A431-01A	34 years, male, white, stage:iic, alive, 568 days	853.3
TCGA-EB-A6QZ-01A	76 years, female, white, stage:iia, dead, 352 days	808.0
TCGA-EB-A5SF-01A	78 years, female, white, stage:iic, dead, 369 days	760.9
TCGA-D9-A3Z4-01A	54 years, male, white, stage:iiic, dead, 519 days	760.3
TCGA-D3-A5GT-01A	43 years, male, white, stage:iiic, alive, 487 days	752.6
TCGA-EB-A44N-01A	59 years, male, white, stage:iic, dead, 205 days	733.1
TCGA-EB-A82C-01A	70 years, female, asian, stage:iic, alive, 17 days	733.0
TCGA-BF-A1PZ-01A	71 years, female, white, stage:iib, alive, 853 days	720.5
TCGA-FS-A1ZN-01A	43 years, male, white, stage:iiia, dead, 730 days	715.8
TCGA-EB-A24C-01A	56 years, male, white, alive, 632 days	676.6
TCGA-EB-A42Y-01A	73 years, female, asian, stage:iic, dead, 721 days	657.0
TCGA-EB-A5FP-01A	65 years, female, white, stage:iv, dead, 454 days	651.4
TCGA-EB-A5UM-01A	48 years, female, white, stage:iic, alive, 779 days	651.4
TCGA-XV-A9W2-01A	81 years, male, white, stage:i, alive, 417 days	646.4
TCGA-BF-AAOU-01A	73 years, female, white, stage:iic, alive, 476 days	637.2
TCGA-BF-A1Q0-01A	80 years, male, white, stage:iic, alive, 831 days	629.6
TCGA-EB-A299-01A	63 years, male, white, stage:iia, alive, 378 days	628.4
TCGA-BF-A5EO-01A	65 years, male, white, stage:iic, alive, 703 days	615.3
TCGA-EB-A5SE-01A	73 years, male, white, stage:iib, dead, 401 days	615.1
TCGA-EB-A550-01A	75 years, female, white, stage:iic, dead, 264 days	610.7
TCGA-EB-A3XD-01A	53 years, female, white, stage:iic, alive, 1160 days	605.4
TCGA-YG-AA3N-01A	67 years, male, stage:iic, alive, 306 days	593.6
TCGA-EB-A44P-01A	58 years, female, white, stage:iic, alive, 741 days	590.4
TCGA-BF-A3DM-01A	63 years, male, white, stage:iia, alive, 601 days	579.5
TCGA-HR-A5NC-01A	90 years, female, alive, 1000 days	563.2
TCGA-ER-A2NB-01A	57 years, male, white, stage:iiib, dead, 857 days	553.0
TCGA-BF-A1PU-01A	46 years, female, white, stage:iic, alive, 387 days	537.1
TCGA-EB-A3HV-01A	37 years, male, white, stage:iic, alive, 39 days	527.9
TCGA-EB-A3Y7-01A	86 years, female, white, stage:iiib, dead, 326 days	522.7
TCGA-D9-A4Z5-01A	68 years, male, white, stage:iib, alive, 218 days	519.9
TCGA-BF-A5ER-01A	63 years, male, white, stage:iic, alive, 327 days	517.4
TCGA-EB-A42Z-01A	49 years, male, asian, stage:iiic, alive, 441 days	515.2
TCGA-BF-AAP1-01A	86 years, male, white, stage:iic, alive, 409 days	500.4
TCGA-EB-A41A-01A	90 years, male, white, stage:iic, alive, 262 days	475.9
TCGA-EB-A4XL-01A	56 years, female, white, stage:iic, alive, 777 days	449.5
TCGA-EB-A6QY-01A	71 years, male, white, stage:iic, alive, 382 days	439.1
TCGA-EB-A1NK-01A	48 years, male, white, stage:iic, alive, 1039 days	430.1
TCGA-BF-A3DL-01A	84 years, female, white, stage:iiib, alive, 769 days	417.1
TCGA-EB-A553-01A	62 years, male, white, stage:iic, alive, 226 days	407.3
TCGA-FR-A726-01A	90 years, male, white, stage:iic, dead, 305 days	393.4
TCGA-EB-A57M-01A	56 years, male, asian, stage:iiib, dead, 472 days	357.1
TCGA-XV-AAZW-01A	62 years, female, white, stage:ii, dead, 393 days	341.2
TCGA-ER-A196-01A	64 years, female, white, stage:iic, alive, 1785 days	331.0
TCGA-EB-A44O-01A	69 years, male, white, stage:iib, alive, 81 days	322.2
TCGA-BF-A5EP-01A	75 years, female, white, stage:iiic, alive, 335 days	320.2
TCGA-EB-A41B-01A	76 years, female, white, stage:iic, alive, 291 days	319.8
TCGA-ER-A19T-01A	51 years, male, white, stage:iv, dead, 270 days	318.1
TCGA-GN-A8LN-01A	68 years, male, white, stage:iic, alive, 772 days	293.6
TCGA-GF-A769-01A	39 years, male, white, stage:iic, dead, 1070 days	276.4
TCGA-BF-A3DN-01A	81 years, female, white, stage:iiic, alive, 717 days	275.2
TCGA-EB-A4IQ-01A	42 years, female, asian, stage:iiib, dead, 636 days	255.6
TCGA-ER-A42H-01A	77 years, male, white, dead, 426 days	254.4
TCGA-XV-A9VZ-01A	90 years, female, white, stage:ii, alive, 11 days	244.4
TCGA-D9-A4Z2-01A	50 years, male, white, stage:iiic, dead, 190 days	215.7
TCGA-FR-A2OS-01A	49 years, female, white, stage:iic, dead, 368 days	196.0
TCGA-BF-AAP6-01A	55 years, male, white, stage:iii, alive, 325 days	192.0
TCGA-GF-A2C7-01A	48 years, male, white, stage:iic, alive, 21 days	178.5
TCGA-BF-A9VF-01A	77 years, male, white, stage:iic, alive, 440 days	142.8
TCGA-EB-A5VU-01A	56 years, male, asian, stage:iiib, dead, 321 days	131.1
TCGA-BF-A1PV-01A	74 years, female, white, stage:iic, alive, 14 days	64.6
TCGA-D9-A4Z3-01A	73 years, female, white, stage:iiic, alive, 505 days	47.6
TCGA-FW-A5DX-01A	71 years, male, white, stage:iiic, alive, 640 days	36.6
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MELANOMA - Protein expressionⁱ

Pending cancer tissue analysis