Metastasis formation is a multistep process that involves cancer cell transmigration through tumor vessels and through the healthy vasculature of the affected organ. This process is limited by an intact vascular barrier formed by endothelial cells, ECM, and pericytes. In a publication in JCI Insight, researchers from HPA and Uppsala University studied the role of the protein CD93 in maintaining vascular integrity in metastatic cancers...Read more

In a publication in Journal of Proteome Research transcriptomics and spatial proteomics were used to investigate and validate the expression of so-called missing proteins in the human ovary...Read more

Platelet factor 4 (gene: PF4) is a chemokine expressed by platelets (thrombocytes) - blood cell fragments that play a key role during blood clotting. Although its normal physiological role is not completely understood, PF4 is implicated in antimicrobial activity and life-threatening thrombosis caused by adenovirus vector covid-19 vaccines...Read more

This month we turn the spotlight to retinol binding protein 2 (gene: RBP2), which plays an important role in the uptake of vitamin A in the intestines. Now that winter has arrived, we increasingly need good night vision and a strong immune system - two physiological processes that we have vitamin A to thank for...Read more

Spermatogenesis is the process where sperm are made, and it involves thousands of genes and proteins that are activated and repressed. The function of a large proportion of these genes and proteins remains unknown and testis harbors many "missing proteins" (MPs)...Read more