Metastasis formation is a multistep process that involves cancer cell transmigration through tumor vessels and through the healthy vasculature of the affected organ. This process is limited by an intact vascular barrier formed by endothelial cells, ECM, and pericytes. In a publication in JCI Insight, researchers from HPA and Uppsala University studied the role of the protein CD93 in maintaining vascular integrity in metastatic cancers...Read more

In a publication in Cancers a comprehensive mass spectrometry strategy was used to profile blood plasma samples from a large pan-cancer cohort including 15 different cancer types. Differential expression analysis and machine learning was then used to identify a potential biomarker panel able to correctly diagnose multiple myeloma...Read more

An interview with the Director of the Human Protein Atlas was recently published online in Technology Networks by the editor Molly Campbell...Read more

Pyruvate kinase muscle type (PKM) is a key enzyme in glycolysis and is a mediator of the Warburg effect in tumors. The association of PKM with survival of cancer patients is controversial. This study investigated the associations of the alternatively spliced transcripts of PKM with cancer patients' survival outcomes and explained the conflicts in previous studies. The article has recently been published in the journal Cancers...Read more

Over time, cells accumulate DNA mutations, that if transcribed and translated influence gene expression and/or function of the protein. The increasing number mutations in eg. genes that control cell division eventually lead formation of tumor...Read more