Expression of MT-ATP6 in melanoma - The Human Protein Atlas

MELANOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

MT-ATP6 is not prognostic in melanoma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 3676.32
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

6846.4

Number of samples

102

Samples

Sample	Description	FPKM
TCGA-EB-A553-01A	62 years, male, white, stage:iic, alive, 226 days	43460.2
TCGA-DA-A960-01A	73 years, male, white, stage:iib, alive, 804 days	29692.5
TCGA-D3-A5GT-01A	43 years, male, white, stage:iiic, alive, 487 days	27375.5
TCGA-ER-A194-01A	77 years, male, white, dead, 1354 days	19059.8
TCGA-EB-A4OY-01A	65 years, female, white, stage:iiib, alive, 977 days	17997.2
TCGA-BF-A5ER-01A	63 years, male, white, stage:iic, alive, 327 days	16975.9
TCGA-FR-A728-01A	54 years, female, white, stage:iiib, alive, 583 days	16370.0
TCGA-EB-A85I-01A	66 years, male, white, stage:iic, alive, 362 days	12921.3
TCGA-EB-A4OZ-01A	42 years, female, white, stage:iiic, alive, 620 days	12537.1
TCGA-GN-A263-01A	24 years, male, white, stage:iv, dead, 467 days	11676.6
TCGA-EB-A5UM-01A	48 years, female, white, stage:iic, alive, 779 days	11170.8
TCGA-ER-A2NB-01A	57 years, male, white, stage:iiib, dead, 857 days	10691.4
TCGA-EB-A551-01A	78 years, female, white, stage:iiic, alive, 590 days	10171.6
TCGA-YG-AA3N-01A	67 years, male, stage:iic, alive, 306 days	9531.4
TCGA-BF-A5EQ-01A	63 years, male, white, stage:iic, alive, 323 days	9302.7
TCGA-BF-A1PX-01A	56 years, male, white, stage:iiib, dead, 282 days	9248.7
TCGA-EB-A5SF-01A	78 years, female, white, stage:iic, dead, 369 days	9111.4
TCGA-FR-A726-01A	90 years, male, white, stage:iic, dead, 305 days	9102.5
TCGA-BF-AAP7-01A	76 years, female, white, stage:iic, alive, 318 days	9024.1
TCGA-BF-AAP8-01A	58 years, male, white, stage:iic, alive, 447 days	8491.4
TCGA-EB-A41A-01A	90 years, male, white, stage:iic, alive, 262 days	8318.3
TCGA-HR-A5NC-01A	90 years, female, alive, 1000 days	8197.6
TCGA-EB-A82B-01A	58 years, female, asian, stage:iii, alive, 390 days	7978.2
TCGA-EB-A6QZ-01A	76 years, female, white, stage:iia, dead, 352 days	7942.8
TCGA-EB-A24D-01A	72 years, male, white, stage:iiib, alive, 645 days	7734.1
TCGA-GN-A4U5-01A	61 years, female, white, stage:ib, alive, 1156 days	7616.1
TCGA-BF-AAOU-01A	73 years, female, white, stage:iic, alive, 476 days	7588.9
TCGA-BF-A3DL-01A	84 years, female, white, stage:iiib, alive, 769 days	7455.7
TCGA-GF-A2C7-01A	48 years, male, white, stage:iic, alive, 21 days	7444.2
TCGA-EB-A57M-01A	56 years, male, asian, stage:iiib, dead, 472 days	7399.7
TCGA-GF-A769-01A	39 years, male, white, stage:iic, dead, 1070 days	7382.2
TCGA-XV-AAZY-01A	76 years, female, white, stage:iiic, alive, 405 days	7381.7
TCGA-EB-A3XB-01A	63 years, male, white, stage:ii, alive, 796 days	7208.0
TCGA-EB-A3Y6-01A	56 years, female, white, stage:iic, alive, 126 days	7159.9
TCGA-ER-A2NF-01A	53 years, male, white, stage:iiib, dead, 877 days	7067.2
TCGA-EB-A6QY-01A	71 years, male, white, stage:iic, alive, 382 days	6744.7
TCGA-EB-A4P0-01A	82 years, male, white, stage:iic, dead, 326 days	6625.8
TCGA-EB-A3Y7-01A	86 years, female, white, stage:iiib, dead, 326 days	6601.1
TCGA-EB-A3XE-01A	77 years, female, white, stage:iia, alive, 180 days	6461.2
TCGA-BF-AAOX-01A	83 years, male, white, stage:iic, alive, 444 days	6339.4
TCGA-XV-A9W2-01A	81 years, male, white, stage:i, alive, 417 days	6245.6
TCGA-EB-A1NK-01A	48 years, male, white, stage:iic, alive, 1039 days	6208.4
TCGA-EB-A42Z-01A	49 years, male, asian, stage:iiic, alive, 441 days	6202.7
TCGA-EB-A5FP-01A	65 years, female, white, stage:iv, dead, 454 days	6172.2
TCGA-IH-A3EA-01A	61 years, male, white, stage:iic, alive, 524 days	6094.4
TCGA-ER-A19K-01A	79 years, female, white, stage:iic, dead, 469 days	6052.7
TCGA-GN-A8LN-01A	68 years, male, white, stage:iic, alive, 772 days	6039.7
TCGA-BF-A9VF-01A	77 years, male, white, stage:iic, alive, 440 days	6005.4
TCGA-EB-A97M-01A	66 years, male, white, stage:iic, alive, 414 days	5866.5
TCGA-EB-A4IQ-01A	42 years, female, asian, stage:iiib, dead, 636 days	5800.2
TCGA-BF-A5EP-01A	75 years, female, white, stage:iiic, alive, 335 days	5767.9
TCGA-XV-AAZW-01A	62 years, female, white, stage:ii, dead, 393 days	5448.5
TCGA-BF-A1PU-01A	46 years, female, white, stage:iic, alive, 387 days	5294.5
TCGA-D9-A4Z2-01A	50 years, male, white, stage:iiic, dead, 190 days	5093.2
TCGA-D9-A3Z4-01A	54 years, male, white, stage:iiic, dead, 519 days	5026.1
TCGA-EB-A3XD-01A	53 years, female, white, stage:iic, alive, 1160 days	4982.2
TCGA-EB-A4XL-01A	56 years, female, white, stage:iic, alive, 777 days	4947.8
TCGA-EB-A431-01A	34 years, male, white, stage:iic, alive, 568 days	4898.0
TCGA-FW-A5DX-01A	71 years, male, white, stage:iiic, alive, 640 days	4865.3
TCGA-EB-A24C-01A	56 years, male, white, alive, 632 days	4744.6
TCGA-EB-A5VU-01A	56 years, male, asian, stage:iiib, dead, 321 days	4743.6
TCGA-BF-A5EO-01A	65 years, male, white, stage:iic, alive, 703 days	4508.4
TCGA-WE-A8K4-01A	85 years, male, white, stage:iib, alive, 614 days	4503.5
TCGA-EB-A51B-01A	53 years, male, white, stage:iic, alive, 931 days	4373.0
TCGA-BF-A5ES-01A	76 years, female, white, stage:iic, alive, 490 days	4320.1
TCGA-BF-A1PZ-01A	71 years, female, white, stage:iib, alive, 853 days	4283.9
TCGA-XV-A9W5-01A	51 years, male, white, stage:i/ii nos, alive, 392 days	4269.0
TCGA-EB-A299-01A	63 years, male, white, stage:iia, alive, 378 days	4251.6
TCGA-EB-A3HV-01A	37 years, male, white, stage:iic, alive, 39 days	4211.9
TCGA-EB-A82C-01A	70 years, female, asian, stage:iic, alive, 17 days	3982.5
TCGA-EB-A42Y-01A	73 years, female, asian, stage:iic, dead, 721 days	3950.5
TCGA-EB-A44P-01A	58 years, female, white, stage:iic, alive, 741 days	3944.6
TCGA-D9-A4Z3-01A	73 years, female, white, stage:iiic, alive, 505 days	3912.1
TCGA-BF-AAP2-01A	62 years, male, white, stage:iib, alive, 405 days	3866.1
TCGA-BF-AAP1-01A	86 years, male, white, stage:iic, alive, 409 days	3759.0
TCGA-D9-A4Z5-01A	68 years, male, white, stage:iib, alive, 218 days	3707.7
TCGA-EB-A85J-01A	66 years, female, white, stage:iib, alive, 360 days	3701.1
TCGA-EB-A550-01A	75 years, female, white, stage:iic, dead, 264 days	3651.5
TCGA-ER-A19T-01A	51 years, male, white, stage:iv, dead, 270 days	3633.9
TCGA-XV-AAZV-01A	56 years, female, white, stage:ii, alive, 412 days	3478.4
TCGA-BF-A3DN-01A	81 years, female, white, stage:iiic, alive, 717 days	3362.4
TCGA-EB-A6R0-01A	58 years, female, white, stage:iic, dead, 608 days	3320.0
TCGA-FR-A3R1-01A	69 years, male, white, stage:iic, alive, 685 days	3207.0
TCGA-BF-AAP6-01A	55 years, male, white, stage:iii, alive, 325 days	3139.2
TCGA-BF-AAP4-01A	61 years, male, white, stage:iic, alive, 335 days	3076.7
TCGA-FR-A2OS-01A	49 years, female, white, stage:iic, dead, 368 days	2958.4
TCGA-ER-A196-01A	64 years, female, white, stage:iic, alive, 1785 days	2795.6
TCGA-BF-A1PV-01A	74 years, female, white, stage:iic, alive, 14 days	2794.9
TCGA-EB-A44N-01A	59 years, male, white, stage:iic, dead, 205 days	2766.1
TCGA-EB-A4IS-01A	77 years, male, white, stage:iib, alive, 774 days	2563.5
TCGA-EB-A41B-01A	76 years, female, white, stage:iic, alive, 291 days	2539.1
TCGA-FS-A1ZN-01A	43 years, male, white, stage:iiia, dead, 730 days	2527.3
TCGA-EB-A3XC-01A	74 years, male, white, stage:iic, alive, 650 days	2527.1
TCGA-BF-A3DJ-01A	36 years, female, white, stage:iiib, alive, 464 days	2388.3
TCGA-BF-A1Q0-01A	80 years, male, white, stage:iic, alive, 831 days	2387.8
TCGA-ER-A42H-01A	77 years, male, white, dead, 426 days	2356.9
TCGA-EB-A3XF-01A	57 years, male, white, stage:iic, alive, 278 days	2200.5
TCGA-EB-A5SE-01A	73 years, male, white, stage:iib, dead, 401 days	2076.7
TCGA-XV-A9VZ-01A	90 years, female, white, stage:ii, alive, 11 days	2061.2
TCGA-GN-A26C-01A	77 years, male, white, stage:iiic, dead, 821 days	1403.2
TCGA-EB-A44O-01A	69 years, male, white, stage:iib, alive, 81 days	1399.4
TCGA-BF-A3DM-01A	63 years, male, white, stage:iia, alive, 601 days	1116.2
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MELANOMA - Protein expressionⁱ

Pending cancer tissue analysis